OCH1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OCH1_YEAST
• UniProt AC: P31755
• Protein Name: Initiation-specific alpha-1,6-mannosyltransferase {ECO:0000305}
• Gene Name: OCH1 {ECO:0000303|PubMed:1523886}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 480
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum.
• Protein Description: Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. Has also the potential to transfer a second alpha-1,6-mannose to the Man(8)GlNAc(2) core oligosaccharide..
• Protein Sequence: MSRKLSHLIATRKSKTIVVTVLLIYSLLTFHLSNKRLLSQFYPSKDDFKQTLLPTTSHSQDINLKKQITVNKKKNQLHNLRDQLSFAFPYDSQAPIPQRVWQTWKVGADDKNFPSSFRTYQKTWSGSYSPDYQYSLISDDSIIPFLENLYAPVPIVIQAFKLMPGNILKADFLRYLLLFARGGIYSDMDTMLLKPIDSWPSQNKSWLNNIIDLNKPIPYKNSKPSLLSSDEISHQPGLVIGIEADPDRDDWSEWYARRIQFCQWTIQAKPGHPILRELILNITATTLASVQNPGVPVSEMIDPRFEEDYNVNYRHKRRHDETYKHSELKNNKNVDGSDIMNWTGPGIFSDIIFEYMNNVLRYNSDILLINPNLNKNDEEGSESATTPAKDVDNDTLSKSTRKFYKKISESLQSSNSMPWEFFSFLKEPVIVDDVMVLPITSFSPDVGQMGAQSSDDKMAFVKHMFSGSWKEDADKNAGHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRKLSHLI ------CCHHHHHHH	37.82	22369663
6	Phosphorylation	--MSRKLSHLIATRK --CCHHHHHHHHCCC	21.20	22369663
45	Acetylation	LSQFYPSKDDFKQTL HHHHCCCCCHHHHHC	57.73	24489116
190	Phosphorylation	GIYSDMDTMLLKPID CCCCCHHHHCCCCCC	11.77	27017623
203	N-linked_Glycosylation	IDSWPSQNKSWLNNI CCCCCCCCHHHHHHH	44.67	-
281	N-linked_Glycosylation	ILRELILNITATTLA HHHHHHHHHHHHHHH	23.67	-
341	N-linked_Glycosylation	VDGSDIMNWTGPGIF CCHHHCCCCCCCCHH	33.23	-
393	N-linked_Glycosylation	TPAKDVDNDTLSKST CCHHHCCCCCCCHHH	43.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OCH1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OCH1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OCH1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KSS1_YEAST	KSS1	genetic	10535982
STE20_YEAST	STE20	genetic	17895367
CLA4_YEAST	CLA4	genetic	17895367
NCPR_YEAST	NCP1	genetic	17895367
ERG4_YEAST	ERG4	genetic	17895367
MNN1_YEAST	MNN1	genetic	18434410
RHO1_YEAST	RHO1	genetic	27769287
FKS2_YEAST	GSC2	genetic	27769287

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.