| UniProt ID | ALDH5_YEAST | |
|---|---|---|
| UniProt AC | P40047 | |
| Protein Name | Aldehyde dehydrogenase 5, mitochondrial | |
| Gene Name | ALD5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 520 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose.. | |
| Protein Sequence | MLSRTRAAAPNSRIFTRSLLRLYSQAPLRVPITLPNGFTYEQPTGLFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPEVRAKALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGNVIDTGKNHFTYSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEAGIPAGVVNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAADTVKKVTLELGGKSPNIVFADADLDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESLKVGDPFDEEVFQGAQTSDKQLHKILDYVDVAKSEGARLVTGGARHGSKGYFVKPTVFADVKEDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDSQYGLAAGIHTNDINKAVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREMGEAALSNYTQTKSVRIAIDKPIR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | Acetylation | FVASKQKKTFDVINP EEECCCCCEEEECCC | 52.51 | 24489116 | |
| 71 | Acetylation | INPSNEEKITTVYKA CCCCCHHHCHHHHHH | 38.89 | 24489116 | |
| 77 | Succinylation | EKITTVYKAMEDDVD HHCHHHHHHHHCCHH | 36.60 | 23954790 | |
| 77 | Acetylation | EKITTVYKAMEDDVD HHCHHHHHHHHCCHH | 36.60 | 24489116 | |
| 97 | Acetylation | AKKAFETKWSIVEPE HHHHHHCCCCCCCHH | 31.57 | 24489116 | |
| 108 | Acetylation | VEPEVRAKALFNLAD CCHHHHHHHHHHHHH | 34.75 | 24489116 | |
| 148 | Acetylation | GDVALVSKYLRSCGG CHHHHHHHHHHHCCC | 40.60 | 24489116 | |
| 161 | Phosphorylation | GGWADKIYGNVIDTG CCCHHHEEEEEEECC | 14.37 | 19823750 | |
| 167 | Phosphorylation | IYGNVIDTGKNHFTY EEEEEEECCCCEEEE | 38.64 | 19795423 | |
| 169 | Acetylation | GNVIDTGKNHFTYSI EEEEECCCCEEEEEE | 49.71 | 24489116 | |
| 268 | Phosphorylation | KIAFTGSTATGRHIM EEEEECCCCCCHHHH | 29.59 | 28889911 | |
| 276 | Acetylation | ATGRHIMKVAADTVK CCCHHHHHHHHHHCC | 28.28 | 24489116 | |
| 305 | Acetylation | FADADLDKAVKNIAF EECCCHHHHHHHHCE | 63.48 | 24489116 | |
| 368 | Acetylation | QGAQTSDKQLHKILD CCCCCCHHHHHHHHH | 55.30 | 24489116 | |
| 372 | Acetylation | TSDKQLHKILDYVDV CCHHHHHHHHHHHHH | 54.26 | 24489116 | |
| 381 | Acetylation | LDYVDVAKSEGARLV HHHHHHHHCCCCEEE | 49.22 | 24489116 | |
| 397 | Acetylation | GGARHGSKGYFVKPT CCCCCCCCCEEECCE | 63.32 | 22865919 | |
| 402 | Acetylation | GSKGYFVKPTVFADV CCCCEEECCEEECCH | 25.68 | 24489116 | |
| 470 | Phosphorylation | SKRVKAGTVWINTYN HHHCCCCCEEEECCC | 19.95 | 19779198 | |
| 475 | Phosphorylation | AGTVWINTYNNFHQN CCCEEEECCCCCCCC | 20.63 | 19779198 | |
| 517 | Acetylation | SVRIAIDKPIR---- EEEEEECCCCC---- | 35.91 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ALDH5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ALDH5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ALDH5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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