| UniProt ID | ATU2_YEAST | |
|---|---|---|
| UniProt AC | P38995 | |
| Protein Name | Copper-transporting ATPase | |
| Gene Name | CCC2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1004 | |
| Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane Multi-pass membrane protein. |
|
| Protein Description | Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles.. | |
| Protein Sequence | MREVILAVHGMTCSACTNTINTQLRALKGVTKCDISLVTNECQVTYDNEVTADSIKEIIEDCGFDCEILRDSEITAISTKEGLLSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQLRLLSKEDEIRFWKKNSIKSTLLAIICMLLYMIVPMMWPTIVQDRIFPYKETSFVRGLFYRDILGVILASYIQFSVGFYFYKAAWASLKHGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIVFDTSIMIISYISIGKYLETLAKSQTSTALSKLIQLTPSVCSIISDVERNETKEIPIELLQVNDIVEIKPGMKIPADGIITRGESEIDESLMTGESILVPKKTGFPVIAGSVNGPGHFYFRTTTVGEETKLANIIKVMKEAQLSKAPIQGYADYLASIFVPGILILAVLTFFIWCFILNISANPPVAFTANTKADNFFICLQTATSVVIVACPCALGLATPTAIMVGTGVGAQNGVLIKGGEVLEKFNSITTFVFDKTGTLTTGFMVVKKFLKDSNWVGNVDEDEVLACIKATESISDHPVSKAIIRYCDGLNCNKALNAVVLESEYVLGKGIVSKCQVNGNTYDICIGNEALILEDALKKSGFINSNVDQGNTVSYVSVNGHVFGLFEINDEVKHDSYATVQYLQRNGYETYMITGDNNSAAKRVAREVGISFENVYSDVSPTGKCDLVKKIQDKEGNNKVAVVGDGINDAPALALSDLGIAISTGTEIAIEAADIVILCGNDLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNIFMIPIAMGVLIPWGITLPPMLAGLAMAFSSVSVVLSSLMLKKWTPPDIESHGISDFKSKFSIGNFWSRLFSTRAIAGEQDIESQAGLMSNEEVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 168 | Ubiquitination | TVILKVTKAFEDESP EEEEEEHHHCCCCCC | 54.81 | 23749301 | |
| 229 | Ubiquitination | HLERTGYKFTVFSNL HHHHHCCEEEEEECC | 35.58 | 17644757 | |
| 291 | Ubiquitination | QDRIFPYKETSFVRG HCCCCCCCCCCCHHH | 55.54 | 24961812 | |
| 424 | Ubiquitination | DVERNETKEIPIELL HCCCCCCCCCCEEEE | 47.68 | 24961812 | |
| 472 | Ubiquitination | GESILVPKKTGFPVI CCCEEECCCCCCCEE | 56.33 | 17644757 | |
| 473 | Ubiquitination | ESILVPKKTGFPVIA CCEEECCCCCCCEEE | 48.05 | 17644757 | |
| 644 | Ubiquitination | MVVKKFLKDSNWVGN EEEHHHHCCCCCCCC | 63.34 | 17644757 | |
| 662 | Ubiquitination | DEVLACIKATESISD HHHHHHHEECCCCCC | 49.49 | 17644757 | |
| 674 | Ubiquitination | ISDHPVSKAIIRYCD CCCCCCHHHHHHHCC | 43.78 | 17644757 | |
| 687 | Ubiquitination | CDGLNCNKALNAVVL CCCCCCCHHHHHHEE | 57.35 | 17644757 | |
| 702 | Ubiquitination | ESEYVLGKGIVSKCQ CCEEECCCCCEEEEE | 41.10 | 17644757 | |
| 795 | Ubiquitination | GDNNSAAKRVAREVG CCCCHHHHHHHHHHC | 47.31 | 17644757 | |
| 967 | Ubiquitination | SHGISDFKSKFSIGN HCCCCHHHHCCCCHH | 58.70 | 23749301 | |
| 969 | Ubiquitination | GISDFKSKFSIGNFW CCCHHHHCCCCHHHH | 43.66 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATU2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATU2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATU2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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