PRPD_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRPD_YEAST
• UniProt AC: Q12428
• Protein Name: Probable 2-methylcitrate dehydratase {ECO:0000250|UniProtKB:P77243}
• Gene Name: PDH1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 516
• Protein Description: Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate..
• Protein Sequence: MFLAKNLKNNKIKVCLPKKKFAALSTASIQTNERPNPDKVLKDIAKYVHETPLKSSLALDTARLCFLDTLGCGLAALKFKQAQNIIKPIVPGTIVPSGTKILGTSYVMDPVKGAFAIGTLIRWLDYNDCWLAAEWGHPSDNLGGILAVADHLSRLNKATHGKNGKQFLVKDVLEAMIKAHEIQGIIALENSFNKVGLDHVVLVKVATAGVVSKMLGLSQEQTIEALSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLAYLVKNANVGTIPSVLTARTWGFYDVLFKGKPFSFQQRSKYDSYVMENVLFKISFPAEFHAQTAVEAAVKAYRILAKQGKTFKDIKSIRIRTQEAAMRIIDKSGPLYNYADRDHCIQYMIAVPLITGNLTATDYSDEVARNPEIDNLRSKMYCIEDTHLTQNYHDPDKRSIGNALLIELNDGTQLDEIFVEYPVGHKFRREEGIPLLMNKFQRHLREHFVESPDKVDLIMKVSSKTNFLNMQIDKYMDLFTEG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Acetylation	KVLKDIAKYVHETPL HHHHHHHHHHHHCCC	48.41	22865919
250	Phosphorylation	PNTGSRKSWAAGDAV CCCCCCCCHHHHHHH	22.34	19779198
258	Phosphorylation	WAAGDAVSRAVNLAY HHHHHHHHHHHHHHH	19.08	27017623
488	Acetylation	HFVESPDKVDLIMKV HHCCCCCCCCEEEEE	40.82	22865919
496	Phosphorylation	VDLIMKVSSKTNFLN CCEEEEECCCCCCHH	22.16	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRPD_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRPD_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRPD_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCS1_YEAST	KCS1	genetic	21623372

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.