CSC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSC1_YEAST
• UniProt AC: Q06538
• Protein Name: Calcium permeable stress-gated cation channel 1
• Gene Name: CSC1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 782
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Acts as an osmosensitive calcium-permeable cation channel..
• Protein Sequence: MTSYIERLKSAASYLDTVPDEHHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQSSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKIDDGNDDDDSESSLIHLVKRIVEGSGDGDNHSAPERTNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEALKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQPYSENYHLLGNEQSGAVTHGENVPSSNNNDEDTILYSQISLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPTAFVTMDSVANAQMAAQAVLDPRVHYFITRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIGFPLVKIKAKTPRQRNELYNPPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGTLAGFEGGWVLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSSIREYERDNSTVNSANEEESYAYPYAVSELEGPMLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	SYIERLKSAASYLDT HHHHHHHHHHHHHHC		28889911
171	N-linked_Glycosylation	EGSGDGDNHSAPERT CCCCCCCCCCCCHHH		-
173	Phosphorylation	SGDGDNHSAPERTNV CCCCCCCCCCHHHHH		27214570
217	Ubiquitination	TRQAYLGKQNTITDR HCHHHCCCCCCCCCC		23749301
220	Phosphorylation	AYLGKQNTITDRTIR HHCCCCCCCCCCEEE		27017623
252	Phosphorylation	IEQLKIGTVSSITIC HHHHCCCCEEEEEEE		27017623
254	Phosphorylation	QLKIGTVSSITICRE HHCCCCEEEEEEEHH		27017623
257	Phosphorylation	IGTVSSITICREWGP CCCEEEEEEEHHHCC		27017623
277	Acetylation	HCRKKILKNLELKYS HHHHHHHHHCCCCHH		25381059
282	Acetylation	ILKNLELKYSECPRE HHHHCCCCHHCCCHH		25381059
300	Phosphorylation	RQPYSENYHLLGNEQ CCCCCCCCEECCCCC		28889911
308	Phosphorylation	HLLGNEQSGAVTHGE EECCCCCCCCCCCCC		28889911
312	Phosphorylation	NEQSGAVTHGENVPS CCCCCCCCCCCCCCC		28889911
319	Phosphorylation	THGENVPSSNNNDED CCCCCCCCCCCCCCC		28889911
320	Phosphorylation	HGENVPSSNNNDEDT CCCCCCCCCCCCCCE		28889911
327	Phosphorylation	SNNNDEDTILYSQIS CCCCCCCEEEEEEEE		28889911
330	Phosphorylation	NDEDTILYSQISLGE CCCCEEEEEEEECCC		28889911
334	Phosphorylation	TILYSQISLGERPKM EEEEEEEECCCCCCC		28889911
757	Phosphorylation	EYERDNSTVNSANEE HHHCCCCCCCCCCHH		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ALG1_YEAST	ALG1	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
PMP1_YEAST	PMP1	physical	16093310
PMP3_YEAST	PMP3	physical	16093310
ATC7_YEAST	NEO1	physical	16093310
SYS1_YEAST	SYS1	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
SLY41_YEAST	SLY41	physical	16093310
HSP71_YEAST	SSA1	physical	22940862
PDC1_YEAST	PDC1	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
PYR1_YEAST	URA2	physical	22940862
AVT5_YEAST	AVT5	genetic	27708008
BUD31_YEAST	BUD31	genetic	27708008
SIN3_YEAST	SIN3	genetic	27708008
WHI5_YEAST	WHI5	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.