| UniProt ID | TBG_YEAST | |
|---|---|---|
| UniProt AC | P53378 | |
| Protein Name | Tubulin gamma chain | |
| Gene Name | TUB4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 473 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. | |
| Protein Description | Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. TUB4 is an important spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays.. | |
| Protein Sequence | MGGEIITLQAGQCGNHVGKFLWSQLAKEHAIGTDGLSQLPDSSTERDDDTKPFFRENSRNKFTPRAIMMDSEPSVIADVENTFRGFFDPRNTWVASDGASAGNSWANGYDIGTRNQDDILNKIDKEIDSTDNFEGFQLLHSVAGGTGSGLGSNLLEALCDRYPKKILTTYSVFPARSSEVVVQSYNTILALRRLIEDSDATVVFDNASLLNISGKVFRNPNIDLQHTNQLISTIISSVTNSIRFPSYMYSSMSSIYSTLIPSPELHFLSPSFTPFTSDYIHDDIAHKGHSSYDVMLDLLDPSNSLVSTAMNNPTYFNVYNTIIGNVEPRQISRAMTKLQQRIKFPSWSSSAMHVNIGRRSPYLPLQPNENEVSGMMLSNMSTVVNVFENACNTFDKVFAKGAFLNNYNVGDLFQSMQNVQDEFAESREVVQSLMEDYVAAEQDSYLDDVLVDDENMVGELEEDLDADGDHKLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | Phosphorylation | GLSQLPDSSTERDDD CHHCCCCCCCCCCCC | 36.90 | 21700874 | |
| 43 | Phosphorylation | LSQLPDSSTERDDDT HHCCCCCCCCCCCCC | 41.49 | 21700874 | |
| 44 | Phosphorylation | SQLPDSSTERDDDTK HCCCCCCCCCCCCCC | 38.70 | 21700874 | |
| 130 | Phosphorylation | IDKEIDSTDNFEGFQ HHHCCCCCCCCCHHH | 31.08 | 21700874 | |
| 227 | Phosphorylation | PNIDLQHTNQLISTI CCCCHHHHHHHHHHH | 16.23 | 21700874 | |
| 232 | Phosphorylation | QHTNQLISTIISSVT HHHHHHHHHHHHHHH | 23.34 | 27017623 | |
| 233 | Phosphorylation | HTNQLISTIISSVTN HHHHHHHHHHHHHHC | 18.48 | 27017623 | |
| 241 | Phosphorylation | IISSVTNSIRFPSYM HHHHHHCCCCCCHHH | 13.03 | 27017623 | |
| 360 | Phosphorylation | HVNIGRRSPYLPLQP EEECCCCCCCCCCCC | 19.28 | 28889911 | |
| 362 | Phosphorylation | NIGRRSPYLPLQPNE ECCCCCCCCCCCCCC | 23.38 | 28889911 | |
| 393 | Phosphorylation | VFENACNTFDKVFAK HHHHHHHHHHHHHHH | 32.85 | 19779198 | |
| 444 | Phosphorylation | YVAAEQDSYLDDVLV HHHHCCCCCCCCEEE | 27.56 | 21700874 | |
| 445 | Phosphorylation | VAAEQDSYLDDVLVD HHHCCCCCCCCEEEC | 23.57 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBG_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBG_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBG_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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