VHR1_YEAST - dbPTM
VHR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VHR1_YEAST
UniProt AC P40522
Protein Name Transcription factor VHR1
Gene Name VHR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 640
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Transcription factor that binds to the VHRE consensus sequence in promoters of VHT1 and BIO5, and regulates their biotin-dependent expression..
Protein Sequence MNGPPTFTQYRINKFSGNGATHKIRELLNFNDEKKWKQFSSRRLELIDKFQLSQYKASEQDQNIKQIATILRTEFGYPVSCSKEFEKLVTAAVQSVRRNRKRSKKRYALSIANGSGGNVNNSISSNSTSDDEISPSIYQRSNSDFLPSSNYAADFQFSNKFQPLMSHQSHNGTIFPTVGTQNDSSPSVTSTQQKYNDIVTMLVHDLVTNVVPLSEQALKDPYTGPNLSHFATSSLSQQPNITTNIPIDSTVPFFLREKLLLQIQRSRTCQDISQAAGSIDIYANLEILGEMSIRMSIAFVIERFFSNLVSSSMKYITAKTCSPENLALLSQRLFGAATRHNLSHFPAAQVQLRLLYLVIGGIVKDFGFDPTLYPLSEIIHHIVMVQYPLASSCASEPPSSSPNKRVKRSPPVVSSDVMLNNNNTLSNRATLLTTLPMKPQSANKDVNRRVIIRFNDREQAFTFHQLSNGPPTVSEVLENCKNLFNIINKNKNFGIFHNDNLLNDESLAKLFDSFSTSEIHLVIKDISTIPLQDAKIPVPITLPKMSCIGENPSMPSIPLVPQEKDDPKKSSLTAFDNILNRISKSPMNEENSNTTLNTGTSTSNTNNNDHNESVPAPYVTKNKNSFQNGNLPQPVFQPLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14AcetylationFTQYRINKFSGNGAT
CCEEEEEECCCCCHH		38.2425381059
34AcetylationLLNFNDEKKWKQFSS
HHCCCCHHHHHHHHH		67.7925381059
141PhosphorylationSPSIYQRSNSDFLPS
CHHHHHHCCCCCCCC		25.7622369663
143PhosphorylationSIYQRSNSDFLPSSN
HHHHHCCCCCCCCCC		30.8722369663
148PhosphorylationSNSDFLPSSNYAADF
CCCCCCCCCCCCCCE		33.1022369663
149PhosphorylationNSDFLPSSNYAADFQ
CCCCCCCCCCCCCEE		31.7422369663
151PhosphorylationDFLPSSNYAADFQFS
CCCCCCCCCCCEECC		12.7119779198
409PhosphorylationPNKRVKRSPPVVSSD
CCCCCCCCCCEECCE		28.0417330950
414PhosphorylationKRSPPVVSSDVMLNN
CCCCCEECCEEECCC		22.5124961812
415PhosphorylationRSPPVVSSDVMLNNN
CCCCEECCEEECCCC		23.7128889911
489AcetylationNLFNIINKNKNFGIF
HHHHHHHCCCCCCCC		59.9125381059
571PhosphorylationKDDPKKSSLTAFDNI
CCCCCCCCCHHHHHH		38.3228889911
583PhosphorylationDNILNRISKSPMNEE
HHHHHHHCCCCCCCC		24.6829136822
585PhosphorylationILNRISKSPMNEENS
HHHHHCCCCCCCCCC		23.6920377248
592PhosphorylationSPMNEENSNTTLNTG
CCCCCCCCCCCCCCC		38.5429136822
594PhosphorylationMNEENSNTTLNTGTS
CCCCCCCCCCCCCCC		32.2629136822
595PhosphorylationNEENSNTTLNTGTST
CCCCCCCCCCCCCCC		23.4329136822
598PhosphorylationNSNTTLNTGTSTSNT
CCCCCCCCCCCCCCC		44.9729136822
600PhosphorylationNTTLNTGTSTSNTNN
CCCCCCCCCCCCCCC		27.1329136822
601PhosphorylationTTLNTGTSTSNTNNN
CCCCCCCCCCCCCCC		31.0529136822
602PhosphorylationTLNTGTSTSNTNNND
CCCCCCCCCCCCCCC		26.3229136822
603PhosphorylationLNTGTSTSNTNNNDH
CCCCCCCCCCCCCCC		41.2329136822
605PhosphorylationTGTSTSNTNNNDHNE
CCCCCCCCCCCCCCC		38.8129136822
613PhosphorylationNNNDHNESVPAPYVT
CCCCCCCCCCCCEEC		38.4229136822
625PhosphorylationYVTKNKNSFQNGNLP
EECCCCCCCCCCCCC		29.8021551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VHR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VHR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VHR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2A2_YEASTHTA2physical
16554755
SNU13_YEASTSNU13physical
16554755
TAL2_YEASTNQM1genetic
25887987
UBA4_YEASTUBA4genetic
25887987
STT3_YEASTSTT3genetic
27708008
DIM1_YEASTDIM1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
ARP4_YEASTARP4genetic
27708008
BUR1_YEASTSGV1genetic
27708008
NPL4_YEASTNPL4genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SLX5_YEASTSLX5genetic
27708008
TNA1_YEASTTNA1genetic
27708008
NCA3_YEASTNCA3genetic
27708008
MPCP_YEASTMIR1genetic
27708008
ILM1_YEASTILM1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
ELF1_YEASTELF1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
HAP5_YEASTHAP5genetic
27708008
SUR1_YEASTSUR1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VHR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND MASSSPECTROMETRY.

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