PKHA1_HUMAN - dbPTM
PKHA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHA1_HUMAN
UniProt AC Q9HB21
Protein Name Pleckstrin homology domain-containing family A member 1
Gene Name PLEKHA1
Organism Homo sapiens (Human).
Sequence Length 404
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein. Nucleus . Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.
Protein Description Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane..
Protein Sequence MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationSGKFLRRYFILDTRE
CCCEEEEEEEEECCC		6.6319664994
42PhosphorylationREDSFVWYMDNPQNL
CCCEEEEECCCCCCC		6.8422817900
62PhosphorylationRVGAIKLTYISKVSD
CEEEEEEEEEEECCC		17.51-
63PhosphorylationVGAIKLTYISKVSDA
EEEEEEEEEEECCCC		17.40-
71PhosphorylationISKVSDATKLRPKAE
EEECCCCCCCCCCCE		35.29-
72UbiquitinationSKVSDATKLRPKAEF
EECCCCCCCCCCCEE		44.19-
109UbiquitinationEWVNVLNKAIKITVP
HHHHHHHHHEEEECC		47.53-
114PhosphorylationLNKAIKITVPKQSDS
HHHHEEEECCCCCCC		26.2524719451
117UbiquitinationAIKITVPKQSDSQPN
HEEEECCCCCCCCCC		59.08-
125PhosphorylationQSDSQPNSDNLSRHG
CCCCCCCCCCCHHCC		34.2625159151
129PhosphorylationQPNSDNLSRHGECGK
CCCCCCCHHCCCCCC		28.6121815630
137AcetylationRHGECGKKQVSYRTD
HCCCCCCCCCCCCCC		41.017366083
153PhosphorylationVGGVPIITPTQKEEV
ECCEEECCCCCHHHH		22.4728555341
157UbiquitinationPIITPTQKEEVNECG
EECCCCCHHHHHHHH		59.32-
166PhosphorylationEVNECGESIDRNNLK
HHHHHHHCCCCCCCC		18.3125159151
173MethylationSIDRNNLKRSQSHLP
CCCCCCCCCHHHCCC		52.72115975157
175PhosphorylationDRNNLKRSQSHLPYF
CCCCCCCHHHCCCCC		34.1521945579
177PhosphorylationNNLKRSQSHLPYFTP
CCCCCHHHCCCCCCC		28.3921945579
181PhosphorylationRSQSHLPYFTPKPPQ
CHHHCCCCCCCCCCC		26.8421945579
183PhosphorylationQSHLPYFTPKPPQDS
HHCCCCCCCCCCCCC		25.2621945579
190PhosphorylationTPKPPQDSAVIKAGY
CCCCCCCCCCEECCE		21.1323312004
200UbiquitinationIKAGYCVKQGAVMKN
EECCEEECCCCCCCC		39.18-
206UbiquitinationVKQGAVMKNWKRRYF
ECCCCCCCCCCHHEE		53.72-
212PhosphorylationMKNWKRRYFQLDENT
CCCCCHHEEECCCCC		10.3429496907
222PhosphorylationLDENTIGYFKSELEK
CCCCCHHHHCHHHHC		12.18-
224UbiquitinationENTIGYFKSELEKEP
CCCHHHHCHHHHCCC		34.24-
225PhosphorylationNTIGYFKSELEKEPL
CCHHHHCHHHHCCCC		37.2022617229
229UbiquitinationYFKSELEKEPLRVIP
HHCHHHHCCCCEEEE		76.802190698
238UbiquitinationPLRVIPLKEVHKVQE
CCEEEEHHHHCCHHH		52.95-
247UbiquitinationVHKVQECKQSDIMMR
HCCHHHHHHCCCCCC		52.68-
249PhosphorylationKVQECKQSDIMMRDN
CHHHHHHCCCCCCCC		18.0129759185
264PhosphorylationLFEIVTTSRTFYVQA
EEEEEEECCEEEEEC		21.6929759185
285PhosphorylationHSWIKAVSGAIVAQR
HHHHHHHHCCEEEEC		27.6324719451
297PhosphorylationAQRGPGRSASSEHPP
EECCCCCCCCCCCCC		38.1228857561
299PhosphorylationRGPGRSASSEHPPGP
CCCCCCCCCCCCCCC		37.1925394399
300PhosphorylationGPGRSASSEHPPGPS
CCCCCCCCCCCCCCC		39.3723090842
300 (in isoform 2)Phosphorylation-39.37-
307PhosphorylationSEHPPGPSESKHAFR
CCCCCCCCCCCCCCC		61.4923312004
308 (in isoform 2)Phosphorylation-67.9229116813
308PhosphorylationEHPPGPSESKHAFRP
CCCCCCCCCCCCCCC		67.9224719451
309PhosphorylationHPPGPSESKHAFRPT
CCCCCCCCCCCCCCC		33.7923312004
316O-linked_GlycosylationSKHAFRPTNAATATS
CCCCCCCCCCCHHCC		32.9830379171
322O-linked_GlycosylationPTNAATATSHSTASR
CCCCCHHCCCCCCCC		23.7130379171
322PhosphorylationPTNAATATSHSTASR
CCCCCHHCCCCCCCC		23.7128348404
323O-linked_GlycosylationTNAATATSHSTASRS
CCCCHHCCCCCCCCC		16.9930379171
323PhosphorylationTNAATATSHSTASRS
CCCCHHCCCCCCCCC		16.9927794612
325O-linked_GlycosylationAATATSHSTASRSNS
CCHHCCCCCCCCCCC		25.9930379171
325PhosphorylationAATATSHSTASRSNS
CCHHCCCCCCCCCCC		25.9928152594
326PhosphorylationATATSHSTASRSNSL
CHHCCCCCCCCCCCE		24.1928152594
328O-linked_GlycosylationATSHSTASRSNSLVS
HCCCCCCCCCCCEEE		36.0130379171
328PhosphorylationATSHSTASRSNSLVS
HCCCCCCCCCCCEEE		36.0128152594
330PhosphorylationSHSTASRSNSLVSTF
CCCCCCCCCCEEEEE		28.4230266825
332PhosphorylationSTASRSNSLVSTFTM
CCCCCCCCEEEEEEE		31.2422167270
335PhosphorylationSRSNSLVSTFTMEKR
CCCCCEEEEEEEECC		24.0930266825
336PhosphorylationRSNSLVSTFTMEKRG
CCCCEEEEEEEECCC		18.6930266825
338PhosphorylationNSLVSTFTMEKRGFY
CCEEEEEEEECCCHH		25.2230266825
345PhosphorylationTMEKRGFYESLAKVK
EEECCCHHHHHCCCC		13.8721945579
347PhosphorylationEKRGFYESLAKVKPG
ECCCHHHHHCCCCCC		23.4221945579
350UbiquitinationGFYESLAKVKPGNFK
CHHHHHCCCCCCCEE		56.96-
352UbiquitinationYESLAKVKPGNFKVQ
HHHHCCCCCCCEEEE		46.64-
357UbiquitinationKVKPGNFKVQTVSPR
CCCCCCEEEEECCCC		37.12-
360PhosphorylationPGNFKVQTVSPREPA
CCCEEEEECCCCCCC		26.4120068231
362PhosphorylationNFKVQTVSPREPASK
CEEEEECCCCCCCCH		22.9425159151
369UbiquitinationSPREPASKVTEQALL
CCCCCCCHHCHHHHH		56.11-
371PhosphorylationREPASKVTEQALLRP
CCCCCHHCHHHHHCC		26.5628102081
380PhosphorylationQALLRPQSKNGPQEK
HHHHCCCCCCCCCCC		30.6725394399
381UbiquitinationALLRPQSKNGPQEKD
HHHCCCCCCCCCCCC		61.75-
398PhosphorylationLVDLDDASLPVSDV-
CCCCCCCCCCCCCC-		39.9520873877
402PhosphorylationDDASLPVSDV-----
CCCCCCCCCC-----		30.6220873877
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PKHA2_HUMANPLEKHA2physical
11802782
MPDZ_HUMANMPDZphysical
11802782
MS3L1_HUMANMSL3physical
28514442
WIPI3_HUMANWDR45Bphysical
28514442
PBX2_HUMANPBX2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHA1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory