dbPTM

HES1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HES1_YEAST
UniProt AC	P35843
Protein Name	Protein HES1
Gene Name	HES1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	434
Subcellular Localization
Protein Description	Plays a role in ergosterol synthesis..
Protein Sequence	MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHWRFDKNLWMRENEITI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
247	Acetylation	TGKKNSFKARIYRSP ECCCCCEEEEEECCC	36.25	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HES1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HES1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HES1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAA38_YEAST	MAK31	genetic	20093466
SLX5_YEAST	SLX5	genetic	20093466
BCS1_YEAST	BCS1	genetic	20093466
RMD8_YEAST	RMD8	genetic	20093466
XRN1_YEAST	XRN1	genetic	20093466
RE104_YEAST	REC104	genetic	20093466
KTR7_YEAST	KTR7	genetic	20093466
PLMT_YEAST	OPI3	genetic	20093466
YMK8_YEAST	YML108W	genetic	20093466
YHM2_YEAST	YHM2	genetic	20093466
ZRC1_YEAST	ZRC1	genetic	20093466
IPB2_YEAST	PBI2	genetic	20093466
YP260_YEAST	YPL260W	genetic	20093466
OSH6_YEAST	OSH6	genetic	11238399
KES1_YEAST	KES1	genetic	21819498
UBP6_YEAST	UBP6	genetic	21987634
UBX2_YEAST	UBX2	genetic	21987634
SLX5_YEAST	SLX5	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
YBQ6_YEAST	YBR056W	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
XRN1_YEAST	XRN1	genetic	27708008
HTD2_YEAST	HTD2	genetic	27708008
RE104_YEAST	REC104	genetic	27708008
YMK8_YEAST	YML108W	genetic	27708008
YET2_YEAST	YET2	genetic	27708008
ZRC1_YEAST	ZRC1	genetic	27708008
IPB2_YEAST	PBI2	genetic	27708008
YN87_YEAST	YNR014W	genetic	27708008
YP260_YEAST	YPL260W	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HES1_YEAST

Related Literatures of Post-Translational Modification