RCR2_YEAST - dbPTM
RCR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RCR2_YEAST
UniProt AC Q03446
Protein Name Protein RCR2
Gene Name RCR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 210
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description
Protein Sequence MILREQIDFLIHKRQDDNNNNGEAITDDDPFSSSSWRWGRWIFFIFFIVALLILLFSTAKVNRRRRIMGQAPIRGTAWLTPPTYRQSERDYNGTQRCVEDYVPEYTETANENDLGFYDERGEFHPNGKTEYLAPPPLSEEQASSTDKDLQRPVAAVVRIPSESEFDFNLLRPTMNNFVNGQSNRNEQHSPTVESSSFDVNNAPARAKVSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
80PhosphorylationIRGTAWLTPPTYRQS
CCCCEECCCCCCCCC		19.2728889911
83PhosphorylationTAWLTPPTYRQSERD
CEECCCCCCCCCCCC		32.3228889911
87PhosphorylationTPPTYRQSERDYNGT
CCCCCCCCCCCCCCC		26.1228889911
128UbiquitinationGEFHPNGKTEYLAPP
CCCCCCCCCCCCCCC		44.8423749301
138PhosphorylationYLAPPPLSEEQASST
CCCCCCCCHHHHCCC		44.8823749301
143PhosphorylationPLSEEQASSTDKDLQ
CCCHHHHCCCCHHCC		33.2028889911
144PhosphorylationLSEEQASSTDKDLQR
CCHHHHCCCCHHCCC		43.5721551504
145PhosphorylationSEEQASSTDKDLQRP
CHHHHCCCCHHCCCC		44.5728889911
147UbiquitinationEQASSTDKDLQRPVA
HHHCCCCHHCCCCEE		61.5023749301
161PhosphorylationAAVVRIPSESEFDFN
EEEEECCCCCCCCCH		51.9224909858
163PhosphorylationVVRIPSESEFDFNLL
EEECCCCCCCCCHHC		48.1522369663
189PhosphorylationSNRNEQHSPTVESSS
CCCCCCCCCCCCCCC		23.2017330950
191PhosphorylationRNEQHSPTVESSSFD
CCCCCCCCCCCCCEE		39.6621082442
194PhosphorylationQHSPTVESSSFDVNN
CCCCCCCCCCEECCC		27.2622890988
195PhosphorylationHSPTVESSSFDVNNA
CCCCCCCCCEECCCC		22.8622890988
196PhosphorylationSPTVESSSFDVNNAP
CCCCCCCCEECCCCC		34.4422890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RCR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RCR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UME6_YEASTUME6genetic
23891562
TVP18_YEASTTVP18genetic
23891562
CSG2_YEASTCSG2genetic
27708008
MED5_YEASTNUT1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
F26_YEASTFBP26genetic
27708008
PTK2_YEASTPTK2genetic
27708008
SCS7_YEASTSCS7genetic
27708008
MSB4_YEASTMSB4genetic
27708008
TBP6_YEASTYTA6genetic
27708008
WDR6_YEASTRTT10genetic
27708008
MED1_YEASTMED1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RCR2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-161; THR-191AND SER-196, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161 AND SER-189, ANDMASS SPECTROMETRY.

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