SAR1_YEAST - dbPTM
SAR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAR1_YEAST
UniProt AC P20606
Protein Name Small COPII coat GTPase SAR1
Gene Name SAR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 190
Subcellular Localization Cytoplasmic vesicle, COPII-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side. Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side. Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side . N
Protein Description Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP by SEC12 binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits..
Protein Sequence MAGWDIFGWFRDVLASLGLWNKHGKLLFLGLDNAGKTTLLHMLKNDRLATLQPTWHPTSEELAIGNIKFTTFDLGGHIQARRLWKDYFPEVNGIVFLVDAADPERFDEARVELDALFNIAELKDVPFVILGNKIDAPNAVSEAELRSALGLLNTTGSQRIEGQRPVEVFMCSVVMRNGYLEAFQWLSQYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22UbiquitinationASLGLWNKHGKLLFL
HHCCCCCCCCCEEEE		42.0022817900
22AcetylationASLGLWNKHGKLLFL
HHCCCCCCCCCEEEE		42.0024489116
25UbiquitinationGLWNKHGKLLFLGLD
CCCCCCCCEEEEECC		41.5622817900
36UbiquitinationLGLDNAGKTTLLHML
EECCCCCCHHHHHHH		35.6117644757
36AcetylationLGLDNAGKTTLLHML
EECCCCCCHHHHHHH		35.6124489116
44AcetylationTTLLHMLKNDRLATL
HHHHHHHHCCCCCCC		49.5924489116
68UbiquitinationELAIGNIKFTTFDLG
CEEECEEEEEEEECC		40.4323749301
133UbiquitinationPFVILGNKIDAPNAV
CEEEECCCCCCCCCC		39.9223749301
147PhosphorylationVSEAELRSALGLLNT
CCHHHHHHHHHCCCC		40.2322369663
154PhosphorylationSALGLLNTTGSQRIE
HHHHCCCCCCCCCCC		32.2922369663
155PhosphorylationALGLLNTTGSQRIEG
HHHCCCCCCCCCCCC		33.4922369663
157PhosphorylationGLLNTTGSQRIEGQR
HCCCCCCCCCCCCCC		17.7522369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TMEDA_YEASTERV25physical
12426381
ERV41_YEASTERV41physical
12426381
ERV46_YEASTERV46physical
12426381
BET1_YEASTBET1physical
9428766
EMP24_YEASTEMP24physical
9428766
GAP1_YEASTGAP1physical
9428766
HIP1_YEASTHIP1physical
9428766
SEC22_YEASTSEC22physical
9428766
SEC23_YEASTSEC23physical
8004676
SEC23_YEASTSEC23physical
12426382
SEC22_YEASTSEC22physical
12426382
ERV29_YEASTERV29physical
12426382
SED5_YEASTSED5physical
12426382
BET1_YEASTBET1physical
12426382
SEC23_YEASTSEC23physical
11907269
SEC24_YEASTSEC24physical
11907269
ERV14_YEASTERV14physical
11907269
SEC23_YEASTSEC23physical
9428766
SEC24_YEASTSEC24physical
9428766
HRD3_YEASTHRD3genetic
9880808
SEC12_YEASTSEC12genetic
9880808
SEC16_YEASTSEC16genetic
9880808
SED4_YEASTSED4genetic
9880808
SED4_YEASTSED4genetic
11168590
IRE1_YEASTIRE1genetic
12176017
HRR25_YEASTHRR25genetic
9920934
TVP15_YEASTTVP15physical
18719252
SEC31_YEASTSEC31physical
22300850
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-155 AND SER-157, ANDMASS SPECTROMETRY.

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