| UniProt ID | HSM3_YEAST | |
|---|---|---|
| UniProt AC | P38348 | |
| Protein Name | DNA mismatch repair protein HSM3 | |
| Gene Name | HSM3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 480 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).. | |
| Protein Sequence | MSEKETNYVENLLTQLENELNEDNLPEDINTLLRKCSLNLVTVVSLPDMDVKPLLATIKRFLTSNVSYDSLNYDYLLDVVDKLVPMADFDDVLEVYSAEDLVKALRSEIDPLKVAACRVIENSQPKGLFATSNIIDILLDILFDEKVENDKLITAIEKALERLSTDELIRRRLFDNNLPYLVSVKGRMETVSFVRLIDFLTIEFQFISGPEFKDIIFCFTKEEILKSVEDILVFIELVNYYTKFLLEIRNQDKYWALRHVKKILPVFAQLFEDTENYPDVRAFSTNCLLQLFAEVSRIEEDEYSLFKTMDKDSLKIGSEAKLITEWLELINPQYLVKYHKDVVENYFHVSGYSIGMLRNLSADEECFNAIRNKFSAEIVLRLPYLEQMQVVETLTRYEYTSKFLLNEMPKVMGSLIGDGSAGAIIDLETVHYRNSALRNLLDKGEEKLSVWYEPLLREYSKAVNGKNYSTGSETKIADCR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | DVKPLLATIKRFLTS CHHHHHHHHHHHHHC | 27.31 | 19795423 | |
| 158 | Ubiquitination | KLITAIEKALERLST HHHHHHHHHHHHCCH | 52.76 | 24961812 | |
| 353 | Phosphorylation | YFHVSGYSIGMLRNL HEECCCCCHHHHCCC | 19.05 | 27017623 | |
| 469 | Phosphorylation | AVNGKNYSTGSETKI HHCCCCCCCCCCCCC | 35.37 | 27717283 | |
| 470 | Phosphorylation | VNGKNYSTGSETKIA HCCCCCCCCCCCCCC | 34.07 | 27717283 | |
| 472 | Phosphorylation | GKNYSTGSETKIADC CCCCCCCCCCCCCCC | 42.03 | 28889911 | |
| 474 | Phosphorylation | NYSTGSETKIADCR- CCCCCCCCCCCCCC- | 29.46 | 27717283 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSM3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSM3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSM3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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