RPN14_YEAST - dbPTM
RPN14_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPN14_YEAST
UniProt AC P53196
Protein Name 26S proteasome regulatory subunit RPN14
Gene Name RPN14
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 417
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Is not a genuine component of the 26S proteasome, but an auxiliary factor that interacts with the proteasomal ATPase of 19S regulatory particle (RP). Acts as a chaperone which regulates the highly structured assembly of the 19S regulatory particle. Involved in the substrate specificity of the 26S proteasome and is especially involved in the degradation of ubiquitinated GCN4. May contribute to the stability of the 26S proteasome in some stress conditions..
Protein Sequence MTKTITVAHIQYDFKAVLEENDENDDEFYINVDKNLNEIKEHKIVVLGNSRGVDAGKGNTFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
88PhosphorylationNTIIRDGSKMLKRAD
EEEEECCCHHHHCCC		21.1228889911
96PhosphorylationKMLKRADYTAVDTAK
HHHHCCCCCEEHHHH		8.8022369663
97PhosphorylationMLKRADYTAVDTAKL
HHHCCCCCEEHHHHH		22.2822369663
101PhosphorylationADYTAVDTAKLQMRR
CCCCEEHHHHHHHHH		21.0622369663
147PhosphorylationTKLKFFPSGEALISS
EEEEECCCCCEEECC		44.0725521595
154PhosphorylationSGEALISSSQDMQLK
CCCEEECCCCCCEEE		25.6525521595
155PhosphorylationGEALISSSQDMQLKI
CCEEECCCCCCEEEE		24.3325521595
284PhosphorylationEQTIQLPSKFTCSCN
CCEEECCCCEEEECE		49.3326447709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPN14_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPN14_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPN14_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRS4_YEASTRPT2physical
11805837
RPN7_YEASTRPN7physical
11805837
RPN13_YEASTRPN13physical
11805837
PRS7_YEASTRPT1physical
11805837
PRS6B_YEASTRPT3physical
11805837
PRS6A_YEASTRPT5physical
11805837
RPN11_YEASTRPN11physical
11805837
RPN10_YEASTRPN10physical
11805837
PRS10_YEASTRPT4physical
11805837
RPN3_YEASTRPN3physical
11805837
RPN9_YEASTRPN9physical
11805837
RPN6_YEASTRPN6physical
11805837
RPN1_YEASTRPN1physical
11805837
RPN5_YEASTRPN5physical
11805837
RPN8_YEASTRPN8physical
11805837
RUVB2_YEASTRVB2physical
11805837
PSD10_YEASTNAS6physical
11805837
HSM3_YEASTHSM3physical
11805837
CHD1_YEASTCHD1genetic
17314980
PRS6A_YEASTRPT5physical
17499717
RPN11_YEASTRPN11physical
17499717
PSD10_YEASTNAS6physical
18719252
RPN8_YEASTRPN8physical
19412159
PRS7_YEASTRPT1physical
19412159
PRS8_YEASTRPT6physical
19412159
PRS6A_YEASTRPT5physical
19412159
PRS10_YEASTRPT4physical
19412159
PSD10_YEASTNAS6genetic
19446322
PRS8_YEASTRPT6genetic
19446322
RPN1_YEASTRPN1physical
19446323
RPN2_YEASTRPN2physical
19446323
RPN3_YEASTRPN3physical
19446323
PRS7_YEASTRPT1physical
19446323
PRS4_YEASTRPT2physical
19446323
PRS6B_YEASTRPT3physical
19446323
PRS10_YEASTRPT4physical
19446323
PRS6A_YEASTRPT5physical
19446323
RPN6_YEASTRPN6physical
19446323
PRS8_YEASTRPT6physical
19446323
RPN5_YEASTRPN5physical
19446323
RPN7_YEASTRPN7physical
19446323
RPN9_YEASTRPN9physical
19446323
RPN8_YEASTRPN8physical
19446323
PSD10_YEASTNAS6physical
19446323
HSM3_YEASTHSM3genetic
19446323
RPN11_YEASTRPN11physical
19446323
PSMD9_YEASTNAS2physical
20471945
PSD10_YEASTNAS6genetic
21878652
PRS8_YEASTRPT6genetic
23562395
ECM29_YEASTECM29genetic
23995839
SSB1_YEASTSSB1genetic
28322792
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPN14_YEAST

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Related Literatures of Post-Translational Modification

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