| UniProt ID | BIR1_YEAST | |
|---|---|---|
| UniProt AC | P47134 | |
| Protein Name | Protein BIR1 | |
| Gene Name | BIR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 954 | |
| Subcellular Localization | ||
| Protein Description | Seems to act in the pleiotropic control of cell division. May participate in chromosome segregation events.. | |
| Protein Sequence | MDGQIDKMEKRYSMTKLENRLRTFQDGVALEKKKLKWSFKVIPYQAMAKLGFYFDPVIDPKTSKLKKDSVRCCYCHRQTYNVRDCRSKRKDVLETLSNIMRQHLTVTDNKQVCLLIYLRNKLLTDYSFHMGVSDWKNDKYFSNPDDENVINLRKFTFQDNWPHSGSQNEHPLGIEKMVNAGLMRYDSSIEGLGDPSMDKTLMNDTCYCIYCKQLLQGWSINDDPMSRHYKVSQNGNCYFFQTRNRFERIKNDNDSITKNCEVSPTLGENGKREVINTKTASQRQCPLFESPPSSTGPQLDDYNEKTDISVIQHNISVLDGAQGENVKRNSVEEKEQINMENGSTTLEEGNINRDVLADKKEVISTPTAKEIKRPNVQLTQSSSPIKKKRKFKRISPRKIFDEEDSEHSLNNNSANGDNKDKDLVIDFTSHIIKNRDVGRKNAILDDSTDEFSFSNQGHNTFDIPIPTSSHLLKGIDSDNDNVIREDDTGINTDTKGASSKHEKFSVNSEEDLNFSEVKLTGRDSSTNILIRTQIVDQNLGDIDRDKVPNGGSPEVPKTHELIRDNSEKREAQNGEFRHQKDSTVRQSPDILHSNKSGDNSSNITAIPKEEQRRGNSKTSSIPADIHPKPRKNLQEPRSLSISGKVVPTERKLDNINIDLNFSASDFSPSSQSEQSSKSSSVISTPVASPKINLTRSLHAVKELSGLKKETDDGKYFTNKQETIKILEDVSVKNETPNNEMLLFETGTPIASQENKSRKLFDEEFSGKELDIPIDSSTVEIKKVIKPEFEPVPSVARNLVSGTSSYPRNSRLEEQRKETSTSLADNSKKGSSFNEGNNEKEPNAAEWFKIDENRHLVKNYFHDLLKYINNNDATLANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFIDDCDKKLDILRRDYYTATNFIETLEDDNQLIDIAKKMGIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 255 | Phosphorylation | RIKNDNDSITKNCEV HHCCCCCCHHCCCEE | 38.11 | 23749301 | |
| 257 | Phosphorylation | KNDNDSITKNCEVSP CCCCCCHHCCCEECC | 21.84 | 27717283 | |
| 263 | Phosphorylation | ITKNCEVSPTLGENG HHCCCEECCCCCCCC | 7.00 | 21082442 | |
| 265 | Phosphorylation | KNCEVSPTLGENGKR CCCEECCCCCCCCCE | 39.63 | 21440633 | |
| 290 | Phosphorylation | RQCPLFESPPSSTGP CCCCCCCCCCCCCCC | 34.47 | 28889911 | |
| 293 | Phosphorylation | PLFESPPSSTGPQLD CCCCCCCCCCCCCCC | 43.87 | 21551504 | |
| 294 | Phosphorylation | LFESPPSSTGPQLDD CCCCCCCCCCCCCCC | 43.06 | 21551504 | |
| 306 | Phosphorylation | LDDYNEKTDISVIQH CCCCCCCCCCEEEEC | 32.18 | 20377248 | |
| 309 | Phosphorylation | YNEKTDISVIQHNIS CCCCCCCEEEECCEE | 18.90 | 21440633 | |
| 316 | Phosphorylation | SVIQHNISVLDGAQG EEEECCEEECCCCCC | 23.19 | 21440633 | |
| 330 | Phosphorylation | GENVKRNSVEEKEQI CCCCCCCCHHHHHHH | 34.63 | 28889911 | |
| 343 | Phosphorylation | QINMENGSTTLEEGN HHCCCCCCEEECCCC | 29.78 | 21440633 | |
| 344 | Phosphorylation | INMENGSTTLEEGNI HCCCCCCEEECCCCC | 36.48 | 27017623 | |
| 345 | Phosphorylation | NMENGSTTLEEGNIN CCCCCCEEECCCCCC | 33.59 | 21440633 | |
| 364 | Phosphorylation | ADKKEVISTPTAKEI CCHHCEECCCCHHHC | 33.25 | 28889911 | |
| 365 | Phosphorylation | DKKEVISTPTAKEIK CHHCEECCCCHHHCC | 17.34 | 25752575 | |
| 367 | Phosphorylation | KEVISTPTAKEIKRP HCEECCCCHHHCCCC | 50.91 | 21440633 | |
| 379 | Phosphorylation | KRPNVQLTQSSSPIK CCCCCCCCCCCCCCC | 14.87 | 19795423 | |
| 381 | Phosphorylation | PNVQLTQSSSPIKKK CCCCCCCCCCCCCCC | 27.78 | 19684113 | |
| 382 | Phosphorylation | NVQLTQSSSPIKKKR CCCCCCCCCCCCCCC | 30.25 | 21440633 | |
| 383 | Phosphorylation | VQLTQSSSPIKKKRK CCCCCCCCCCCCCCC | 35.57 | 19823750 | |
| 395 | Phosphorylation | KRKFKRISPRKIFDE CCCCCCCCCCCCCCC | 23.76 | 28889911 | |
| 405 | Phosphorylation | KIFDEEDSEHSLNNN CCCCCCCCCCCCCCC | 40.25 | 22369663 | |
| 408 | Phosphorylation | DEEDSEHSLNNNSAN CCCCCCCCCCCCCCC | 28.83 | 22369663 | |
| 413 | Phosphorylation | EHSLNNNSANGDNKD CCCCCCCCCCCCCCC | 25.82 | 22369663 | |
| 452 | Phosphorylation | DDSTDEFSFSNQGHN CCCCCCCCCCCCCCC | 26.22 | 21440633 | |
| 454 | Phosphorylation | STDEFSFSNQGHNTF CCCCCCCCCCCCCCE | 27.35 | 21440633 | |
| 477 | Phosphorylation | HLLKGIDSDNDNVIR HHHCCCCCCCCCCCC | 36.07 | 22369663 | |
| 488 | Phosphorylation | NVIREDDTGINTDTK CCCCCCCCCCCCCCC | 52.89 | 21551504 | |
| 492 | Phosphorylation | EDDTGINTDTKGASS CCCCCCCCCCCCCCC | 43.03 | 24961812 | |
| 505 | Phosphorylation | SSKHEKFSVNSEEDL CCCCCCCCCCCHHHC | 31.30 | 22369663 | |
| 508 | Phosphorylation | HEKFSVNSEEDLNFS CCCCCCCCHHHCCCC | 39.96 | 22369663 | |
| 515 | Phosphorylation | SEEDLNFSEVKLTGR CHHHCCCCEEEEECC | 40.17 | 22369663 | |
| 520 | Phosphorylation | NFSEVKLTGRDSSTN CCCEEEEECCCCCCC | 25.18 | 22369663 | |
| 524 | Phosphorylation | VKLTGRDSSTNILIR EEEECCCCCCCEEEE | 37.39 | 22369663 | |
| 525 | Phosphorylation | KLTGRDSSTNILIRT EEECCCCCCCEEEEE | 29.75 | 22369663 | |
| 526 | Phosphorylation | LTGRDSSTNILIRTQ EECCCCCCCEEEEEE | 30.17 | 22369663 | |
| 552 | Phosphorylation | DKVPNGGSPEVPKTH CCCCCCCCCCCCCHH | 21.20 | 21082442 | |
| 582 | Phosphorylation | EFRHQKDSTVRQSPD CCCCCCCCCCCCCCC | 35.52 | 22369663 | |
| 583 | Phosphorylation | FRHQKDSTVRQSPDI CCCCCCCCCCCCCCC | 29.82 | 22369663 | |
| 587 | Phosphorylation | KDSTVRQSPDILHSN CCCCCCCCCCCCCCC | 17.61 | 22369663 | |
| 593 | Phosphorylation | QSPDILHSNKSGDNS CCCCCCCCCCCCCCC | 42.37 | 22369663 | |
| 596 | Phosphorylation | DILHSNKSGDNSSNI CCCCCCCCCCCCCCC | 56.48 | 22369663 | |
| 600 | Phosphorylation | SNKSGDNSSNITAIP CCCCCCCCCCCEECC | 29.51 | 22369663 | |
| 601 | Phosphorylation | NKSGDNSSNITAIPK CCCCCCCCCCEECCH | 38.21 | 22369663 | |
| 604 | Phosphorylation | GDNSSNITAIPKEEQ CCCCCCCEECCHHHH | 23.84 | 23749301 | |
| 618 | Phosphorylation | QRRGNSKTSSIPADI HHCCCCCCCCCCCCC | 27.77 | 28889911 | |
| 619 | Phosphorylation | RRGNSKTSSIPADIH HCCCCCCCCCCCCCC | 29.97 | 21551504 | |
| 620 | Phosphorylation | RGNSKTSSIPADIHP CCCCCCCCCCCCCCC | 37.51 | 21440633 | |
| 638 | Phosphorylation | KNLQEPRSLSISGKV CCCCCCCCCCCCCEE | 36.86 | 25521595 | |
| 640 | Phosphorylation | LQEPRSLSISGKVVP CCCCCCCCCCCEEEC | 18.89 | 20377248 | |
| 642 | Phosphorylation | EPRSLSISGKVVPTE CCCCCCCCCEEECCC | 29.23 | 21440633 | |
| 644 | Acetylation | RSLSISGKVVPTERK CCCCCCCEEECCCCC | 33.01 | 24489116 | |
| 667 | Phosphorylation | NFSASDFSPSSQSEQ CCCHHHCCCCCCCCC | 28.94 | 28889911 | |
| 684 | Phosphorylation | KSSSVISTPVASPKI CCCCCCCCCCCCCCC | 15.62 | 28889911 | |
| 688 | Phosphorylation | VISTPVASPKINLTR CCCCCCCCCCCCHHH | 27.28 | 28889911 | |
| 694 | Phosphorylation | ASPKINLTRSLHAVK CCCCCCHHHHHHHHH | 17.45 | 20377248 | |
| 696 | Phosphorylation | PKINLTRSLHAVKEL CCCCHHHHHHHHHHH | 21.19 | 20377248 | |
| 701 | Acetylation | TRSLHAVKELSGLKK HHHHHHHHHHHCCCC | 54.44 | 25381059 | |
| 704 | Phosphorylation | LHAVKELSGLKKETD HHHHHHHHCCCCCCC | 43.07 | 17563356 | |
| 730 | Phosphorylation | IKILEDVSVKNETPN HHEEECCCCCCCCCC | 39.43 | 22369663 | |
| 735 | Phosphorylation | DVSVKNETPNNEMLL CCCCCCCCCCCCEEE | 40.48 | 21440633 | |
| 745 | Phosphorylation | NEMLLFETGTPIASQ CCEEEEECCCCCCCC | 38.73 | 21440633 | |
| 747 | Phosphorylation | MLLFETGTPIASQEN EEEEECCCCCCCCCH | 20.95 | 21440633 | |
| 751 | Phosphorylation | ETGTPIASQENKSRK ECCCCCCCCCHHHHH | 38.45 | 21440633 | |
| 765 | Phosphorylation | KLFDEEFSGKELDIP HCCCHHHCCCCCCCC | 52.84 | 22369663 | |
| 775 | Phosphorylation | ELDIPIDSSTVEIKK CCCCCCCCCCEEEEE | 28.73 | 21440633 | |
| 776 | Phosphorylation | LDIPIDSSTVEIKKV CCCCCCCCCEEEEEH | 32.49 | 21440633 | |
| 777 | Phosphorylation | DIPIDSSTVEIKKVI CCCCCCCCEEEEEHH | 26.55 | 21440633 | |
| 800 | Phosphorylation | SVARNLVSGTSSYPR CHHHHHCCCCCCCCC | 39.25 | 25752575 | |
| 802 | Phosphorylation | ARNLVSGTSSYPRNS HHHHCCCCCCCCCCH | 13.64 | 24961812 | |
| 803 | Phosphorylation | RNLVSGTSSYPRNSR HHHCCCCCCCCCCHH | 31.25 | 24961812 | |
| 804 | Phosphorylation | NLVSGTSSYPRNSRL HHCCCCCCCCCCHHH | 38.71 | 24961812 | |
| 805 | Phosphorylation | LVSGTSSYPRNSRLE HCCCCCCCCCCHHHH | 13.13 | 24961812 | |
| 809 | Phosphorylation | TSSYPRNSRLEEQRK CCCCCCCHHHHHHHH | 39.25 | 19779198 | |
| 818 | Phosphorylation | LEEQRKETSTSLADN HHHHHHHHHCCHHCC | 40.10 | 30377154 | |
| 819 | Phosphorylation | EEQRKETSTSLADNS HHHHHHHHCCHHCCC | 19.65 | 23749301 | |
| 820 | Phosphorylation | EQRKETSTSLADNSK HHHHHHHCCHHCCCC | 34.87 | 23749301 | |
| 821 | Phosphorylation | QRKETSTSLADNSKK HHHHHHCCHHCCCCC | 22.71 | 23749301 | |
| 826 | Phosphorylation | STSLADNSKKGSSFN HCCHHCCCCCCCCCC | 35.97 | 28889911 | |
| 830 | Phosphorylation | ADNSKKGSSFNEGNN HCCCCCCCCCCCCCC | 40.41 | 27717283 | |
| 831 | Phosphorylation | DNSKKGSSFNEGNNE CCCCCCCCCCCCCCC | 40.54 | 21440633 | |
| 878 | Ubiquitination | DATLANDKDGDLAFL CCCCCCCCCCCEEEE | 64.52 | 23749301 | |
| 920 | Acetylation | FIDDCDKKLDILRRD HHHHHHHHHHHHHHC | 37.83 | 23572591 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BIR1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BIR1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BIR1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-508; SER-524;SER-552; SER-587; SER-601; THR-745; SER-751 AND SER-800, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-477; SER-524; SER-525AND SER-704, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-587, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508, AND MASSSPECTROMETRY. | |
