GIR2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIR2_YEAST
• UniProt AC: Q03768
• Protein Name: Protein GIR2
• Gene Name: GIR2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 265
• Protein Description: Acts as a negative regulator of the GCN2 kinase activity by disrupting the GCN1-GCN2 interaction in amino acid-starved cells. [PubMed: 19448108]
• Protein Sequence: MDYKEEQKQELEVLESIYPDELRIINDEYPKIKFEVAIKLELDTGDSTSVLTKEHTIIAEFKLPENYPDEPCLISLEAQEVALNDNEEDNEEDEDEVEYDDHGNKVLKKFENLPDLISFKGYLPELTVQLESQIETDMLLGMQMCFALISSIKERCEQWYSEQLNKLEKQYELEAQEREKKEQAKFHGTKVTRESYLEWRSKFRQELKLDERDQVRRMKAHHGKLTGKQMFEQGVVGTGDEYMEEDDASVDDVAKGLAKTEIANQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Acetylation	IINDEYPKIKFEVAI ECCCCCCCCEEEEEE	58.59	24489116
259	Ubiquitination	DVAKGLAKTEIANQ- HHHHHHHHHHHHCC-	52.30	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIR2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIR2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIR2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG2_YEAST	RBG2	physical	14759368
GIR2_YEAST	GIR2	physical	14759368
RBG2_YEAST	RBG2	physical	16554755
YIP2_YEAST	YIL152W	physical	16554755
VMA22_YEAST	VMA22	physical	18467557
RBG2_YEAST	RBG2	physical	18467557
ISR1_YEAST	ISR1	physical	18467557
STP1_YEAST	STP1	genetic	19061648
CHD1_YEAST	CHD1	genetic	19061648
RS8A_YEAST	RPS8A	genetic	19061648
RS8B_YEAST	RPS8A	genetic	19061648
DBP3_YEAST	DBP3	genetic	19061648
LTV1_YEAST	LTV1	genetic	19061648
HIR2_YEAST	HIR2	genetic	19061648
CSK22_YEAST	CKA2	genetic	19061648
UAF30_YEAST	UAF30	genetic	19061648
APQ12_YEAST	APQ12	genetic	19061648
RBG1_YEAST	RBG1	physical	19448108
GCN1_YEAST	GCN1	physical	19448108
RBG2_YEAST	RBG2	physical	23899355
GCN1_YEAST	GCN1	physical	23899355
MGR1_YEAST	MGR1	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
TPO5_YEAST	TPO5	genetic	27708008
YMS4_YEAST	YMR034C	genetic	27708008
YNN4_YEAST	YNL134C	genetic	27708008
ENB1_YEAST	ENB1	genetic	27708008
JKIP2_HUMAN	JAKMIP2	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.