JKIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JKIP2_HUMAN
• UniProt AC: Q96AA8
• Protein Name: Janus kinase and microtubule-interacting protein 2
• Gene Name: JAKMIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 810
• Subcellular Localization: Golgi apparatus .
• Protein Sequence: MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRKHG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	IELHQEKSKVSKLER HHHHHHHHHHHHHHH	37.22	29514088
45	Phosphorylation	HQEKSKVSKLEREKT HHHHHHHHHHHHHHH	34.95	29514088
116	Phosphorylation	GEIQRLKSALCALRD HHHHHHHHHHHHHHC	30.94	-
122	Methylation	KSALCALRDGSSDKV HHHHHHHHCCCCCHH	27.93	24394859
126	Phosphorylation	CALRDGSSDKVRTAL HHHHCCCCCHHHEEE	47.16	27251275
130	Methylation	DGSSDKVRTALTIEA CCCCCHHHEEEEHHH	21.74	24394867
131	Phosphorylation	GSSDKVRTALTIEAR CCCCHHHEEEEHHHH	29.07	27251275
134	Phosphorylation	DKVRTALTIEAREEA CHHHEEEEHHHHHHH	17.82	27251275
138	Methylation	TALTIEAREEARKLF EEEEHHHHHHHHHHC	29.51	24394875
190	Phosphorylation	DLRSEHQSHQEAISK CCHHHHHHHHHHHHH	29.10	-
196	Phosphorylation	QSHQEAISKIKWESE HHHHHHHHHCCCCCH	35.06	-
202	Phosphorylation	ISKIKWESERDIRRL HHHCCCCCHHHHHHH	36.50	-
241	Acetylation	VQKLQLQKEALDEQL HHHHHHHHHHHHHHH	54.25	12430169
252	Acetylation	DEQLFLVKEAECNMS HHHHHHHHHHHCCCC	54.04	12430179
273	Phosphorylation	PGRAGDGSEHCSSPD CCCCCCCCCCCCCHH	28.98	27732954
277	Phosphorylation	GDGSEHCSSPDLRRN CCCCCCCCCHHHHHH	46.98	27732954
278	Phosphorylation	DGSEHCSSPDLRRNQ CCCCCCCCHHHHHHH	28.03	27732954
352	Acetylation	QRMEEKLKAVTKENS HHHHHHHHHHHHCCH	52.45	24848969
356	Acetylation	EKLKAVTKENSEMRE HHHHHHHHCCHHHHH	48.58	24848977
376	Phosphorylation	PPLKKLKSLNDLDQA CCHHHCCCCCCHHHC	42.72	30576142
422	Phosphorylation	RRRKHRRSSKPIKRP HHHHHHCCCCCCCCC	42.54	-
522	Phosphorylation	LQAEVLRYKAKIEDL HHHHHHHHHHHHHHH	15.90	-
532	Phosphorylation	KIEDLEATLAQKGQD HHHHHHHHHHHCCCC	17.16	-
598	Phosphorylation	LEERERRSPPFNLQI HHHHHHCCCCCCCEE	43.05	24076635
700	Ubiquitination	KIKGYLEEELDYRKQ HHHCHHHHHHHHHHH	62.35	32142685
711	Ubiquitination	YRKQALDQAYMRIQE HHHHHHHHHHHHHHH	34.93	-
713	Phosphorylation	KQALDQAYMRIQELE HHHHHHHHHHHHHHH	4.94	28331001
721	Ubiquitination	MRIQELEATLYNALQ HHHHHHHHHHHHHHH	18.61	32142685
740	Phosphorylation	IKFGELLSEKQQEEL HHHHHHCCHHHHHHH	56.20	24719451
742	Ubiquitination	FGELLSEKQQEELRT HHHHCCHHHHHHHHH	54.64	32142685
753	Ubiquitination	ELRTAVEKLRRQMLR HHHHHHHHHHHHHHH	40.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JKIP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JKIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JKIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI29_HUMAN	TRIM29	physical	16189514
JKIP2_HUMAN	JAKMIP2	physical	25416956
CLAP1_HUMAN	CLASP1	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
KIF9_HUMAN	KIF9	physical	25416956
RM11_HUMAN	MRPL11	physical	25416956
CLIP4_HUMAN	CLIP4	physical	25416956
EFHC2_HUMAN	EFHC2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.