CLIP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIP4_HUMAN
• UniProt AC: Q8N3C7
• Protein Name: CAP-Gly domain-containing linker protein 4
• Gene Name: CLIP4
• Organism: Homo sapiens (Human).
• Sequence Length: 705
• Protein Sequence: MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDCEFSFFDPNDASCQEILFDPKTSVSELFAILRQWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTNMNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPADVVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGINGSKLVDENC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Ubiquitination	TLLHYTCKSGAHGIG HHHEHHCCCCCCCCC	44.09	-
258	Phosphorylation	LLDAVPLSCNISKAM HHHHHCCCCCCCHHH	10.07	25690035
262	Phosphorylation	VPLSCNISKAMLPNY HCCCCCCCHHHCCCC	10.60	25690035
269	Phosphorylation	SKAMLPNYDHVTGKA CHHHCCCCCCCCCHH	12.89	27642862
312 (in isoform 4)	Phosphorylation	-	10.44	28842319
347	Phosphorylation	YGIFAPLSKISKAKG CCEEEEHHHHHHHCC	27.21	-
364	Phosphorylation	KNITHTPSTKAAVPL CCCCCCCCCHHHHHH	43.63	27251275
424	Phosphorylation	KDVALLGSVSSCSST HHHHHHCCCCCCCCC	20.85	27080861
426	Phosphorylation	VALLGSVSSCSSTSS HHHHCCCCCCCCCCC	27.59	27080861
427	Phosphorylation	ALLGSVSSCSSTSSL HHHCCCCCCCCCCCH	18.83	27080861
429	Phosphorylation	LGSVSSCSSTSSLEH HCCCCCCCCCCCHHH	38.30	27080861
433	Phosphorylation	SSCSSTSSLEHRQSY CCCCCCCCHHHHHHC	37.55	27080861
439	Phosphorylation	SSLEHRQSYPKKQNA CCHHHHHHCCHHHHC	43.27	24719451
440	Phosphorylation	SLEHRQSYPKKQNAI CHHHHHHCCHHHHCC	15.67	-
455	Phosphorylation	SSNKKTMSKSPSLSS CCCCCCCCCCCCHHH	34.90	28122231
457	Phosphorylation	NKKTMSKSPSLSSRA CCCCCCCCCCHHHHH	16.65	26437602
459	Phosphorylation	KTMSKSPSLSSRASA CCCCCCCCHHHHHCC	48.23	28122231
461	Phosphorylation	MSKSPSLSSRASAGL CCCCCCHHHHHCCCC	23.32	28122231
462	Phosphorylation	SKSPSLSSRASAGLN CCCCCHHHHHCCCCC	36.84	22210691
465	Phosphorylation	PSLSSRASAGLNSSA CCHHHHHCCCCCCCC	23.04	19276368
470	Phosphorylation	RASAGLNSSATSTAN HHCCCCCCCCCCCCC	26.79	19276368
479	Phosphorylation	ATSTANNSRCEGELR CCCCCCCCCCEEEEE	37.81	22210691
539	Phosphorylation	GVQYFSCSPRYGIFA CEEEEEECCCCEECC	15.94	-
555	Phosphorylation	PSRVQRVTDSLDTLS HHHHHHHHHCCHHHH	23.27	28122231
557	Phosphorylation	RVQRVTDSLDTLSEI HHHHHHHCCHHHHHH	20.84	29978859
560	Phosphorylation	RVTDSLDTLSEISSN HHHHCCHHHHHHHHC	37.16	28348404
579	Phosphorylation	SYPGFRRSFSTTSAS CCCCCCCCCCCCCHH	21.20	30266825
581	Phosphorylation	PGFRRSFSTTSASSQ CCCCCCCCCCCHHHH	31.83	30266825
582	Phosphorylation	GFRRSFSTTSASSQK CCCCCCCCCCHHHHH	23.82	30266825
583	Phosphorylation	FRRSFSTTSASSQKE CCCCCCCCCHHHHHH	22.54	30266825
584	Phosphorylation	RRSFSTTSASSQKEI CCCCCCCCHHHHHHH	26.66	30266825
586	Phosphorylation	SFSTTSASSQKEINR CCCCCCHHHHHHHHH	32.82	30266825
587	Phosphorylation	FSTTSASSQKEINRR CCCCCHHHHHHHHHH	45.01	23090842
607	Phosphorylation	SKAALRRSWSSTPTA HHHHHHHHHCCCCCC	25.52	22617229
609	Phosphorylation	AALRRSWSSTPTAGG HHHHHHHCCCCCCCC	26.11	22617229
610	Phosphorylation	ALRRSWSSTPTAGGI HHHHHHCCCCCCCCE	31.95	28450419
611	Phosphorylation	LRRSWSSTPTAGGIE HHHHHCCCCCCCCEE	21.10	28464451
613	Phosphorylation	RSWSSTPTAGGIEGS HHHCCCCCCCCEECE	37.71	29514088
627	Phosphorylation	SVKLHEGSQVLLTSS EEEEECCCEEEEEEC	17.71	-
664	Acetylation	ELRSAKGKNDGSVGD HHHCCCCCCCCCCCC	51.68	30587711
672	Acetylation	NDGSVGDKRYFTCKP CCCCCCCCEEEEECC	42.97	30587717
674	Phosphorylation	GSVGDKRYFTCKPNH CCCCCCEEEEECCCC	14.69	30631047
691	Phosphorylation	LVRPSRVTYRGINGS EECCCCEEECCCCCC	13.34	25056879
692	Phosphorylation	VRPSRVTYRGINGSK ECCCCEEECCCCCCC	12.18	26267517

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LZTS2_HUMAN	LZTS2	physical	25416956
ZN114_HUMAN	ZNF114	physical	25416956
K1161_HUMAN	KIAA1161	physical	28514442
AMPH_HUMAN	AMPH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-609, AND MASSSPECTROMETRY.
PubMed: 19690332