YGO0_YEAST - dbPTM
YGO0_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YGO0_YEAST
UniProt AC P53120
Protein Name Uncharacterized membrane protein YGL140C
Gene Name YGL140C
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1219
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description
Protein Sequence MSLKSKLTKIQKLWLYYFPCDRILAKRICKSTVNTTVAFIFCLIPKITAHLGAAPAMLPMISVIVHPGRRVGGTIHGAIYCITGLIFGLAYAIFGRFLAQRCLGSSWHELTEAQQHVLHYKRYEAGLAILAVFEVIMLFFHGWMRSVSHYYFGIVFPLFVVVHFAFMDPLNETAGTIAKAYSTPFYLGIAMSIFWNLVLFPEWGTTYLGNTTIDAMNELHKSIDYSINFFIAVDPHNSSQLYSRDPVSLGKLLKMKSLISSKVNNCRVVLHECIYEFTYAYVSPTKLKPIISTLENLTVFINGLVNTCQLEFILLARHDNKLRPDDVAALTLPKNKEISFANAEKLLKVIDKLHPVIYSLHRTMSECMYIAKLVLAHAFDVKVSRVHSCSMFKDGNFPTFSNNANNLPNDVDIQNKINDLKQALEECKAKFKSEMLSFDIDIMSPSDEMFLLSSFLLNFRQTADSTLVIMESVKDILVKRQIQEKKGWLRGKRLWFLVLTNYETFSIWLKGDRNSVTENDTLKGTFNGNTNGFAHDTVIRRPDYEENELLSQKVSSNKNIVKDDASLDLPMTSEPKGNSSSTSDTSSSPLTLTKTTTFGTNRTSRRQGRFSFMSMLISIDKFCEVSHPHFRFGFQVAIALMLASFPMFIPKTRQWYIDYRGTWIGFVCILCLEPSVGGTFWVFFLRAVGVIFGAAWGYLSYVAAVNQTNPYLETVITVFGAIPGFYYLLGTPYVKAAIIEIISIYIVMLAAILPSQDDILTSFAKRCLAVGYGGGVALIVQVFFFPLKAREQLNEEISFVCGCISEMELLYATGLEGEQVASSMSEEKYKKIEKISKSAKEALARATAYKGLTRQEPRLKGEYTELENVFTQVIFIQKQIIERIDTISLLRKQNGSAVIEEFNSVVYPYRRQMVGSISCLMRALQEAFINKTPLPQFLPSARIAHRRLINKVRQTLRIRYPGQISNLSDKARKPNEGDYADGKDEDDDDNEGLVMKMNRRGQANTTANPHEYVLKEKFLSWNASSAASEEIIEYIEELLNLTKILVGVNEFKYGFLSRPLYEDWAAEAVTGFDNFINGKSNPMNTRRNRTPFDGTSIISEGNESLQSTNSNESQISPDSTRSYEPECPVAYEKNDNPAALNLLRIASHKAGQNADGLPKTFRNRAFSITSTSGQLSSLSRHSTLGNADPNYLNDDDESSDDDLPLALKMVLSHMKEKKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
257PhosphorylationGKLLKMKSLISSKVN
HHHHHHHHHHCCCCC		27.6921440633
261PhosphorylationKMKSLISSKVNNCRV
HHHHHHCCCCCCCCH		33.3621440633
321UbiquitinationLLARHDNKLRPDDVA
HHHCCCCCCCCCCEE		52.5117644757
334UbiquitinationVAALTLPKNKEISFA
EEEEECCCCCCCCCC		81.4417644757
336UbiquitinationALTLPKNKEISFANA
EEECCCCCCCCCCCH		63.6523749301
352AcetylationKLLKVIDKLHPVIYS
HHHHHHHHHHHHHHH		37.2624489116
372UbiquitinationSECMYIAKLVLAHAF
HHHHHHHHHHHHHHH		29.5717644757
382UbiquitinationLAHAFDVKVSRVHSC
HHHHHCCEEEEEEEC		36.0217644757
393UbiquitinationVHSCSMFKDGNFPTF
EEECCCCCCCCCCCC		56.9617644757
416UbiquitinationNDVDIQNKINDLKQA
CCHHHHHHHHHHHHH		26.8917644757
462PhosphorylationFLLNFRQTADSTLVI
HHHHHHHCCCCEEEE		28.3327017623
465PhosphorylationNFRQTADSTLVIMES
HHHHCCCCEEEEEHH		22.6030377154
472PhosphorylationSTLVIMESVKDILVK
CEEEEEHHHHHHHHH		19.6530377154
553UbiquitinationENELLSQKVSSNKNI
HHHHHHHHHHCCCCC		40.4824961812
566PhosphorylationNIVKDDASLDLPMTS
CCCCCCCCCCCCCCC		29.4328152593
576UbiquitinationLPMTSEPKGNSSSTS
CCCCCCCCCCCCCCC		67.6717644757
579PhosphorylationTSEPKGNSSSTSDTS
CCCCCCCCCCCCCCC		34.0428889911
581PhosphorylationEPKGNSSSTSDTSSS
CCCCCCCCCCCCCCC		31.5823749301
585PhosphorylationNSSSTSDTSSSPLTL
CCCCCCCCCCCCEEE		30.2128889911
586PhosphorylationSSSTSDTSSSPLTLT
CCCCCCCCCCCEEEE		33.5327214570
587PhosphorylationSSTSDTSSSPLTLTK
CCCCCCCCCCEEEEE		37.7621551504
588PhosphorylationSTSDTSSSPLTLTKT
CCCCCCCCCEEEEEE		24.5625752575
591PhosphorylationDTSSSPLTLTKTTTF
CCCCCCEEEEEEEEC		35.4530377154
594UbiquitinationSSPLTLTKTTTFGTN
CCCEEEEEEEECCCC		47.1623749301
597PhosphorylationLTLTKTTTFGTNRTS
EEEEEEEECCCCCCC		25.8727214570
860UbiquitinationTRQEPRLKGEYTELE
CCCCCCCCCCCHHHH		51.4817644757
878UbiquitinationTQVIFIQKQIIERID
HHHHHHHHHHHHHHH		38.3517644757
931UbiquitinationLQEAFINKTPLPQFL
HHHHHCCCCCCCCCC		46.8624961812
965PhosphorylationIRYPGQISNLSDKAR
CCCCCCCCCCCHHCC		24.6730377154
970UbiquitinationQISNLSDKARKPNEG
CCCCCCHHCCCCCCC		46.8717644757
983UbiquitinationEGDYADGKDEDDDDN
CCCCCCCCCCCCCCC		59.5023749301
1005PhosphorylationNRRGQANTTANPHEY
ECCCCCCCCCCHHHH		30.2428889911
1012PhosphorylationTTANPHEYVLKEKFL
CCCCHHHHHHHHHHH		14.1928889911
1080PhosphorylationDNFINGKSNPMNTRR
CCHHCCCCCCCCCCC		47.7927017623
1122PhosphorylationISPDSTRSYEPECPV
CCCCCCCCCCCCCCC		33.6628889911
1123PhosphorylationSPDSTRSYEPECPVA
CCCCCCCCCCCCCCE		32.0127214570
1147PhosphorylationLNLLRIASHKAGQNA
HHHHHHHHHHCCCCC		24.1321440633
1167PhosphorylationTFRNRAFSITSTSGQ
CHHHCCEEEECCCCC		24.7917330950
1169PhosphorylationRNRAFSITSTSGQLS
HHCCEEEECCCCCHH		25.4228889911
1170PhosphorylationNRAFSITSTSGQLSS
HCCEEEECCCCCHHH		20.9317330950
1171PhosphorylationRAFSITSTSGQLSSL
CCEEEECCCCCHHHH		28.3828889911
1172PhosphorylationAFSITSTSGQLSSLS
CEEEECCCCCHHHHH		25.0621440633
1176PhosphorylationTSTSGQLSSLSRHST
ECCCCCHHHHHHCCC		22.7330377154
1177PhosphorylationSTSGQLSSLSRHSTL
CCCCCHHHHHHCCCC		38.6719779198
1179PhosphorylationSGQLSSLSRHSTLGN
CCCHHHHHHCCCCCC		29.8719779198
1182PhosphorylationLSSLSRHSTLGNADP
HHHHHHCCCCCCCCC		24.9819779198
1183PhosphorylationSSLSRHSTLGNADPN
HHHHHCCCCCCCCCC		32.3419779198
1191PhosphorylationLGNADPNYLNDDDES
CCCCCCCCCCCCCCC		16.5719795423
1198PhosphorylationYLNDDDESSDDDLPL
CCCCCCCCCCCCHHH		46.1717330950
1199PhosphorylationLNDDDESSDDDLPLA
CCCCCCCCCCCHHHH		42.9117330950
1212PhosphorylationLALKMVLSHMKEKKD
HHHHHHHHHHHHHCC		15.3221440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YGO0_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YGO0_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YGO0_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAP3_YEASTBAP3genetic
27708008
SWC5_YEASTSWC5genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
VPS53_YEASTVPS53genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
PEX13_YEASTPEX13genetic
27708008
RAD14_YEASTRAD14genetic
27708008
YM16A_YEASTYMR316C-Agenetic
27708008
RU2A_YEASTLEA1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YGO0_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-566; SER-1167; THR-1169;SER-1198 AND SER-1199, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1167; SER-1198 ANDSER-1199, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1167, AND MASSSPECTROMETRY.

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