dbPTM

YEA6_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YEA6_YEAST
UniProt AC	P39953
Protein Name	Mitochondrial nicotinamide adenine dinucleotide transporter 2
Gene Name	YEA6
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	335
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Mitochondrial inner membrane carrier protein involved in the import of NAD(+) into mitochondria by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP..
Protein Sequence	MNNGDNKTTLENSKNASLANGNYAIPTKLNRLKKNADPRVAAISGALSGALSAMLVCPFDVAKTRLQAQGLQNMTHQSQHYKGFFGTFATIFKDEGAAGLYKGLQPTVLGYIPTLMIYFSVYDFCRKYSVDIFPHSPFLSNASSAITAGAISTVATNPIWVVKTRLMLQTGIGKYSTHYKGTIDTFRKIIQQEGAKALYAGLVPALLGMLNVAIQFPLYENLKIRFGYSESTDVSTDVTSSNFQKLILASMLSKMVASTVTYPHEILRTRMQLKSDLPNTVQRHLLPLIKITYRQEGFAGFYSGFATNLVRTVPAAVVTLVSFEYSKKYLTTFFQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MNNGDNKTTLENSKN CCCCCCCCCCCCCCC	42.75	28889911
9	Phosphorylation	NNGDNKTTLENSKNA CCCCCCCCCCCCCCC	33.41	28889911
17	Phosphorylation	LENSKNASLANGNYA CCCCCCCCCCCCCEE	37.09	28889911
23	Phosphorylation	ASLANGNYAIPTKLN CCCCCCCEECCHHHH	13.80	28889911
275	Phosphorylation	RTRMQLKSDLPNTVQ HHHHHHHCCCCHHHH	53.63	17563356
280	Phosphorylation	LKSDLPNTVQRHLLP HHCCCCHHHHHHHHH	18.97	17563356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YEA6_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YEA6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YEA6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OMS1_YEAST	OMS1	genetic	20093466
PT122_YEAST	PET122	genetic	20093466
YGY5_YEAST	YGL235W	genetic	20093466
CYP8_YEAST	CPR8	genetic	20093466
YN8H_YEAST	YNR029C	genetic	20093466
ALG12_YEAST	ALG12	genetic	20093466
PP2A4_YEAST	PPG1	genetic	20093466
THI20_YEAST	THI20	genetic	20093466
AIM39_YEAST	AIM39	genetic	20093466
PEX15_YEAST	PEX15	genetic	20093466
NOP12_YEAST	NOP12	genetic	20093466
YOL19_YEAST	YOL019W	genetic	20093466
HST3_YEAST	HST3	genetic	20093466
DFG16_YEAST	DFG16	genetic	20093466
CYC2_YEAST	CYC2	genetic	20093466
GLO4_YEAST	GLO4	genetic	20093466
WHI2_YEAST	WHI2	genetic	20093466
CSK22_YEAST	CKA2	genetic	20093466
VPS5_YEAST	VPS5	genetic	20093466
UBA3_YEAST	UBA3	genetic	20093466
AXL1_YEAST	AXL1	genetic	20093466
MRM2_YEAST	MRM2	genetic	27708008
ALG12_YEAST	ALG12	genetic	27708008
PP2A4_YEAST	PPG1	genetic	27708008
AIM39_YEAST	AIM39	genetic	27708008
THI20_YEAST	THI20	genetic	27708008
IRA2_YEAST	IRA2	genetic	27708008
SEA4_YEAST	SEA4	genetic	27708008
OMS1_YEAST	OMS1	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
YIA6_YEAST	YIA6	genetic	27708008
CBT1_YEAST	CBT1	genetic	27708008
PEX15_YEAST	PEX15	genetic	27708008
CYC2_YEAST	CYC2	genetic	27708008
GLO4_YEAST	GLO4	genetic	27708008
WHI2_YEAST	WHI2	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008
AXL1_YEAST	AXL1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YEA6_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275 AND THR-280, ANDMASS SPECTROMETRY.	17563356 [Abstract]