RPI1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPI1_YEAST
• UniProt AC: P23250
• Protein Name: Negative RAS protein regulator protein
• Gene Name: RPI1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 407
• Subcellular Localization: Nucleus .
• Protein Description: Negative regulator of the Ras-cyclic AMP pathway. Negatively regulate the activity of normal but not mutationally activated Ras proteins. The down-regulatory effect of RPI1 requires the presence of one of the two Ras GTPase activators, IRA1 and IRA2..
• Protein Sequence: MYLEYLQPKLNLMDESSTISKNFPDYSPNLNTPITSNFNEETGSDCSLVTPRIISSSNSNSNSNSNSNSNSNSGSIDENELNNSNSSSSSARQIRKKWKEPEDIAFITTIMNNSQLLTFVEYFKPMKNFWKKISKILFQQYGYERNSRQCHDRFKVLYTKSLKVHPSKKSKQKKKKSKQEAGSNLNFDPSKLSRMQYLLVQLQNTFSFVNGNIILKSQKTLKPNKNGTNDNINNHYYNNCNNNNNNINNSNNSNNNNSNNINRNSNHSTNVFSTPEHIQSSINLDKLESLPALDTKGEPSFISPAQFSLLSSAPADNLILQTPPSPFFQQTMPIQLPRDAQQEQISPVFSTDVIYMWQTMFNTIENLKEQVNCLKNEVKQLNHKFYQQNKPLHNMSTSDSENFMQQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	NLNTPITSNFNEETG CCCCCCCCCCCCCCC	39.89	19779198
42	Phosphorylation	TSNFNEETGSDCSLV CCCCCCCCCCCCEEE	35.49	19779198
44	Phosphorylation	NFNEETGSDCSLVTP CCCCCCCCCCEEECC	42.75	21440633
47	Phosphorylation	EETGSDCSLVTPRII CCCCCCCEEECCEEE	30.75	21440633
158	Phosphorylation	HDRFKVLYTKSLKVH HHHHHEEEEECCCCC	18.34	28889911
159	Phosphorylation	DRFKVLYTKSLKVHP HHHHEEEEECCCCCC	15.25	28889911
265	Phosphorylation	SNNINRNSNHSTNVF CCCCCCCCCCCCCCC	32.46	19779198
268	Phosphorylation	INRNSNHSTNVFSTP CCCCCCCCCCCCCCH	26.40	22369663
269	Phosphorylation	NRNSNHSTNVFSTPE CCCCCCCCCCCCCHH	28.05	22369663
273	Phosphorylation	NHSTNVFSTPEHIQS CCCCCCCCCHHHHHH	38.48	22369663
274	Phosphorylation	HSTNVFSTPEHIQSS CCCCCCCCHHHHHHH	22.64	22369663
280	Phosphorylation	STPEHIQSSINLDKL CCHHHHHHHCCHHHH	32.36	22369663
281	Phosphorylation	TPEHIQSSINLDKLE CHHHHHHHCCHHHHH	10.10	22369663
289	Phosphorylation	INLDKLESLPALDTK CCHHHHHCCCCCCCC	50.52	28889911
386	Phosphorylation	KQLNHKFYQQNKPLH HHHHHHHHHCCCCCC	17.62	21551504
396	Phosphorylation	NKPLHNMSTSDSENF CCCCCCCCCCCHHHH	30.03	20377248
397	Phosphorylation	KPLHNMSTSDSENFM CCCCCCCCCCHHHHH	26.28	22369663
398	Phosphorylation	PLHNMSTSDSENFMQ CCCCCCCCCHHHHHH	31.65	20377248
400	Phosphorylation	HNMSTSDSENFMQQH CCCCCCCHHHHHHCC	33.92	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPI1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPI1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPI1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE2_YEAST	PDE2	genetic	12455971
SLT2_YEAST	SLT2	genetic	12455971
ZRT1_YEAST	ZRT1	genetic	20093466
MED5_YEAST	NUT1	genetic	20093466
EF1G2_YEAST	TEF4	genetic	20093466
YKR18_YEAST	YKR018C	genetic	20093466
UPS1_YEAST	UPS1	genetic	20093466
FKS1_YEAST	FKS1	genetic	20093466
ROM2_YEAST	ROM2	genetic	20093466
EOS1_YEAST	EOS1	genetic	20093466
MDM12_YEAST	MDM12	genetic	20093466
PMA2_YEAST	PMA2	genetic	20093466
MGA2_YEAST	MGA2	genetic	20959818
SPT8_YEAST	SPT8	genetic	20959818
UME1_YEAST	UME1	genetic	20959818
UBP3_YEAST	UBP3	genetic	20959818
PHO23_YEAST	PHO23	genetic	20959818
SKN7_YEAST	SKN7	genetic	21127252
SPR3_YEAST	SPR3	physical	22875988
PRP6_YEAST	PRP6	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
DPOD_YEAST	POL3	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
CDC4_YEAST	CDC4	genetic	27708008
TEL2_YEAST	TEL2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.