YHP1_YEAST - dbPTM
YHP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YHP1_YEAST
UniProt AC Q04116
Protein Name Homeobox protein YHP1
Gene Name YHP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 353
Subcellular Localization Nucleus.
Protein Description Transcriptional repressor required to restrict transcription of ECB-dependent genes to the G1/M phase by repressing their transcription during S late phase. Genes that contain a ECB (early cell box) element in their transcription regulatory region are transcribed only during G1/M phases. Binds the IMEI regulatory region in vitro, its relevance in vivo is however unclear..
Protein Sequence MESRNTVLPSLPNIITGTSNSPFQLHTLPNTNFPSDDQGDIRLPPLAASAHIVRPVVNIYKSPCDEERPKRKSPQAVDFLSQRVTTSMTPLSKPKKLSSHSPFTPTVRVCSKEQPPQSMHSYKKVNILTPLSAAKAVLTPTTRKEKKRSFAFITHSQETFPKKEPKIDNARLARRKRRRTSSYELGILQTAFDECPTPNKAKRIELSEQCNMSEKSVQIWFQNKRQAAKKHKNSGNTSHCKVHSNDSMSMISYSDAALEITSTPTSTKEAITAELLKTSPANTSSIFEDHHITPCKPGGQLKFHRKSVLVKRTLSNTGHSEIIKSPKGKENRLKFNAYERKPLGEVDLNSFKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62PhosphorylationPVVNIYKSPCDEERP
CCCHHHCCCCCCCCC		17.4928889911
73PhosphorylationEERPKRKSPQAVDFL
CCCCCCCCHHHHHHH		26.6928889911
86PhosphorylationFLSQRVTTSMTPLSK
HHHHHCCCCCCCCCC		17.4028152593
101PhosphorylationPKKLSSHSPFTPTVR
CCCCCCCCCCCCEEE		24.5328889911
111PhosphorylationTPTVRVCSKEQPPQS
CCEEEECCCCCCCCC		36.0528889911
121PhosphorylationQPPQSMHSYKKVNIL
CCCCCCCCCCEEEEE		29.9728889911
122PhosphorylationPPQSMHSYKKVNILT
CCCCCCCCCEEEEEC		10.5128889911
129PhosphorylationYKKVNILTPLSAAKA
CCEEEEECHHHHHHH		20.5628889911
132PhosphorylationVNILTPLSAAKAVLT
EEEECHHHHHHHHCC		27.6424961812
139PhosphorylationSAAKAVLTPTTRKEK
HHHHHHCCCCCCCCH		16.4021440633
141PhosphorylationAKAVLTPTTRKEKKR
HHHHCCCCCCCCHHC		33.7221551504
142PhosphorylationKAVLTPTTRKEKKRS
HHHCCCCCCCCHHCC		40.7326447709
253PhosphorylationDSMSMISYSDAALEI
CCEEEEEECCCEEEE		10.3119779198
265PhosphorylationLEITSTPTSTKEAIT
EEEECCCCCHHHHHH		49.4719779198
272PhosphorylationTSTKEAITAELLKTS
CCHHHHHHHHHHHCC		22.5621440633
278PhosphorylationITAELLKTSPANTSS
HHHHHHHCCCCCCCH		39.6521551504
279PhosphorylationTAELLKTSPANTSSI
HHHHHHCCCCCCCHH		22.0421440633
284PhosphorylationKTSPANTSSIFEDHH
HCCCCCCCHHHCCCC		22.6521440633
293PhosphorylationIFEDHHITPCKPGGQ
HHCCCCCCCCCCCCE		20.4821440633
313PhosphorylationKSVLVKRTLSNTGHS
CEEEEEEECCCCCCC		28.9019823750
315PhosphorylationVLVKRTLSNTGHSEI
EEEEEECCCCCCCCC		31.5620377248
317PhosphorylationVKRTLSNTGHSEIIK
EEEECCCCCCCCCCC		32.6621440633
320PhosphorylationTLSNTGHSEIIKSPK
ECCCCCCCCCCCCCC		31.6619823750
325PhosphorylationGHSEIIKSPKGKENR
CCCCCCCCCCCCCCC		22.8021440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YHP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YHP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YHP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC10_YEASTCDC10genetic
17314980
REI1_YEASTREI1genetic
17314980
POLH_YEASTRAD30genetic
17314980
IWR1_YEASTIWR1genetic
17314980
NOT2_YEASTCDC36genetic
17314980
PLPHP_YEASTYBL036Cgenetic
17314980
RTG2_YEASTRTG2genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SS120_YEASTSSP120genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
AIM11_YEASTAIM11genetic
27708008
SHC1_YEASTSHC1genetic
27708008
YFF1_YEASTYFL051Cgenetic
27708008
KSS1_YEASTKSS1genetic
27708008
CHO2_YEASTCHO2genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
EOS1_YEASTEOS1genetic
27708008
RAS2_YEASTRAS2genetic
27708008
NAA30_YEASTMAK3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YHP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND MASSSPECTROMETRY.

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