YCU1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YCU1_YEAST
• UniProt AC: P25631
• Protein Name: Ankyrin repeat-containing protein YCR051W
• Gene Name: YCR051W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 222
• Protein Sequence: MNANIWVAASDGNLDRVEHILRESKGAMTPQSKDINGYTPMHAAAAYGHLDLLKKMCNEYNGDINVLDNDGDTPLHHVEDVATARLIVEELGGDFTIRNVEGQTPYDSFVENGEDGELIEYMRIKSGVADVHGVDGVQGEGVIDSKLLEEFKDNVRYTLENDPEEGADEATLQRRRQLEQIITGDNAEEELERYIRAMVREQMLGQGSMAGSGDEPDSKRRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Acetylation	EHILRESKGAMTPQS HHHHHHCCCCCCCCC	46.03	25381059
29	Phosphorylation	RESKGAMTPQSKDIN HHCCCCCCCCCCCCC	20.03	28889911
96	Phosphorylation	EELGGDFTIRNVEGQ HHHCCCEEEEECCCC	24.62	22369663
145	Phosphorylation	QGEGVIDSKLLEEFK CCCCCCCHHHHHHHH	17.68	22369663
146	Ubiquitination	GEGVIDSKLLEEFKD CCCCCCHHHHHHHHH	54.03	24961812
152	Ubiquitination	SKLLEEFKDNVRYTL HHHHHHHHHHCEEEC	52.23	24961812
152	Acetylation	SKLLEEFKDNVRYTL HHHHHHHHHHCEEEC	52.23	24489116
171	Phosphorylation	EEGADEATLQRRRQL CCCCCHHHHHHHHHH	22.75	27017623
183	Phosphorylation	RQLEQIITGDNAEEE HHHHHHHHCCCHHHH	39.86	28889911
208	Phosphorylation	EQMLGQGSMAGSGDE HHHHCCCCCCCCCCC	9.51	30377154
212	Phosphorylation	GQGSMAGSGDEPDSK CCCCCCCCCCCCCHH	33.27	22369663
218	Phosphorylation	GSGDEPDSKRRK--- CCCCCCCHHCCC---	38.48	22369663
219	Ubiquitination	SGDEPDSKRRK---- CCCCCCHHCCC----	64.70	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YCU1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YCU1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YCU1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YE14_YEAST	TOG1	physical	18719252
SRS2_YEAST	SRS2	genetic	21459050
LNX1_HUMAN	LNX1	physical	27107014
BCKD_HUMAN	BCKDK	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212, AND MASSSPECTROMETRY.
PubMed: 17563356

"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-183, AND MASSSPECTROMETRY.
PubMed: 12872131