YP247_YEAST - dbPTM
YP247_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YP247_YEAST
UniProt AC Q12523
Protein Name WD repeat-containing protein YPL247C
Gene Name YPL247C
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Cytoplasm . Nucleus .
Protein Description
Protein Sequence MDPFHNGNKRSSISFGSSQRQPYNKNNYLSGTNGPSSAAQDQGRGPSPFGMSGNTTNGGNSKRNSGCDLSATYYASRSPMYSPLDFSPPVFSPNHSQLQQARGYAANIPVVSNLMNPSMASVCEYQSHYPLFGLDWSADDYVCLGSYKEDSRNKLQVLHSNDLLSWESVVDADVVYPVSKIQWVPSQLYPRKLATCSDSLRIWSVSPEERQFQEQINLSLCKYNRQHPANPAAADDMKVIGTFPPITSFDWNTVDTNLIISSSIDTTCIVWDLQSSHYVKTQLIAHDSEVFDVRFLTKSTQLFASCGGDGSVRVFDLRSLAHSTIIYEPPSSSVSGATAGTITPSSKGSDALLRLEPSPYDPNVLATFAADSNKIIILDMRNPESPILNLQGHGSSVNGIKWHPTKRNVLLSCGDDCQVLYWDLNSSFMEINAAGSKSPSIHGTSLEDPDGDTEMTDGGAGSGLNEDPLSLNNNSKQVCKTLETPNMMYANKTQEINNIAWRPQRGDWFGCVSGKKFQNVRVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9AcetylationDPFHNGNKRSSISFG
CCCCCCCCCCCCCCC		55.8725381059
11PhosphorylationFHNGNKRSSISFGSS
CCCCCCCCCCCCCCC		33.3622369663
12PhosphorylationHNGNKRSSISFGSSQ
CCCCCCCCCCCCCCC		26.7022369663
14PhosphorylationGNKRSSISFGSSQRQ
CCCCCCCCCCCCCCC		26.0422369663
17PhosphorylationRSSISFGSSQRQPYN
CCCCCCCCCCCCCCC		22.6830377154
28PhosphorylationQPYNKNNYLSGTNGP
CCCCCCCCCCCCCCC		16.1922369663
30PhosphorylationYNKNNYLSGTNGPSS
CCCCCCCCCCCCCCH		32.9622369663
32PhosphorylationKNNYLSGTNGPSSAA
CCCCCCCCCCCCHHH		33.3622369663
36PhosphorylationLSGTNGPSSAAQDQG
CCCCCCCCHHHHCCC		33.7322369663
37PhosphorylationSGTNGPSSAAQDQGR
CCCCCCCHHHHCCCC		30.6622369663
47PhosphorylationQDQGRGPSPFGMSGN
HCCCCCCCCCCCCCC		35.3722369663
52PhosphorylationGPSPFGMSGNTTNGG
CCCCCCCCCCCCCCC		29.3022369663
55PhosphorylationPFGMSGNTTNGGNSK
CCCCCCCCCCCCCCC		25.7622369663
56PhosphorylationFGMSGNTTNGGNSKR
CCCCCCCCCCCCCCC		35.5522369663
61PhosphorylationNTTNGGNSKRNSGCD
CCCCCCCCCCCCCCC		35.9522369663
65PhosphorylationGGNSKRNSGCDLSAT
CCCCCCCCCCCCCCE		44.8522369663
70PhosphorylationRNSGCDLSATYYASR
CCCCCCCCCEEECCC		12.8128889911
78PhosphorylationATYYASRSPMYSPLD
CEEECCCCCCCCCCC		16.1222369663
81PhosphorylationYASRSPMYSPLDFSP
ECCCCCCCCCCCCCC		15.5522369663
82PhosphorylationASRSPMYSPLDFSPP
CCCCCCCCCCCCCCC		16.8522369663
87PhosphorylationMYSPLDFSPPVFSPN
CCCCCCCCCCCCCCC		28.1422369663
96PhosphorylationPVFSPNHSQLQQARG
CCCCCCHHHHHHHHH		38.9519779198
319PhosphorylationVRVFDLRSLAHSTII
EEEEEHHHCCEEEEE		36.8922369663
323PhosphorylationDLRSLAHSTIIYEPP
EHHHCCEEEEEECCC		18.7222369663
324PhosphorylationLRSLAHSTIIYEPPS
HHHCCEEEEEECCCC		11.0922369663
335PhosphorylationEPPSSSVSGATAGTI
CCCCCCCCCCCCCEE		25.3422369663
338PhosphorylationSSSVSGATAGTITPS
CCCCCCCCCCEECCC		29.1922369663
341PhosphorylationVSGATAGTITPSSKG
CCCCCCCEECCCCCC		21.1522369663
343PhosphorylationGATAGTITPSSKGSD
CCCCCEECCCCCCCC		19.5622369663
345PhosphorylationTAGTITPSSKGSDAL
CCCEECCCCCCCCCE		35.7122369663
346PhosphorylationAGTITPSSKGSDALL
CCEECCCCCCCCCEE		42.0922369663
438PhosphorylationINAAGSKSPSIHGTS
ECCCCCCCCCCCCCC		26.1028889911
440PhosphorylationAAGSKSPSIHGTSLE
CCCCCCCCCCCCCCC		34.0220377248
444PhosphorylationKSPSIHGTSLEDPDG
CCCCCCCCCCCCCCC		18.9021440633
445PhosphorylationSPSIHGTSLEDPDGD
CCCCCCCCCCCCCCC		34.0619779198
481PhosphorylationNSKQVCKTLETPNMM
CCHHHHHHCCCCCCC		25.3827017623
484PhosphorylationQVCKTLETPNMMYAN
HHHHHCCCCCCCCCC		24.0727017623
489PhosphorylationLETPNMMYANKTQEI
CCCCCCCCCCCCEEE		9.0327017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YP247_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YP247_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YP247_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP60_YEASTHSP60physical
16554755
PP2B1_YEASTCNA1physical
24930733
PP2B2_YEASTCMP2physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YP247_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-47; SER-65;THR-343 AND SER-438, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND MASSSPECTROMETRY.

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