| UniProt ID | LAA1_YEAST | |
|---|---|---|
| UniProt AC | P39526 | |
| Protein Name | AP-1 accessory protein LAA1 | |
| Gene Name | LAA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2014 | |
| Subcellular Localization | Golgi apparatus . Colocalizes with AP-1 adapter complex, with clathrin-coated vesicles to the late-Golgi apparatus and with ribosomes. Localization depends on ADP-ribosylation factor (ARF). | |
| Protein Description | Involved in the trans-Golgi network (TGN)-endosome transport. Important for the correct localization of the adapter protein complex AP-1.. | |
| Protein Sequence | MANRSLKKVIETSSNNGHDLLTWITTNLEKLICLKEVNDNEIQEVKEIHTQLDEFVRYISVLENTDDLELHSVFISLSQLYTISIWRLKDEYPGVVFDSAAFLTNVLCEEDVSIDDGDTDPNQKKKKKKSSTKKKKYIYSPAKDIACTILVQLFENFGSSISSLIPLLFNAIFKNLKKIMEKSKYYHATFMTTLLQLFNAILRNSNNDDKILDPATYAKFSKLSKTVFDSISTDEKDFSVTFVSVLIECWTAHFKQTNFIREHSHDIIETIYSRFTEGEIGVYGFANDETRIFTAKSLAEILFDYYFSKNILTLQEVWSIYVKIFLNCDTRDVESGCFESIIHLINLNLLADNTFLSNSKYLDIVLSLSGVFSSYEVNNRSMNTLSRYLRYFQHMHEVILPHLNDSAKTQMLYYILGCSDTYQSSSKSDSASNFKYSIDAKPETQWLTLLQLDFTYVLISDLGSTFTTEENTVKEIRDKLVDLATCEIFTIRVHTVEILKVFLNNCPEYLSETIENSLRALSTDFKSTGKFIFHKNHGHAFIIANLIKGAESDYISYELIMRITVFSTSFIKNNTTSTSSNLYFKGLLCWILLIGLMNYKDEQYLKLQIPQLFLFWKVLLTHTYTYHDEDELYKNLEIRNHALTCLLTYLSNTTIDKEMAKQVSYLLTKCSNFNHSIDLKSKNIDNALLHNENRILQVYLKLEKYINSDFNSSLLILIVKNFSDPNLYTESSSSVLGSLKDIGNRKVSNKDDMESNIVLESSINTLLRQNNGFAFGLSSKITGDRIVNLSMSSAYKYDESISGSWPSKDYNWYNIFEVEVSKPISPILSLDSLILLYGSGSYSQIDRYAPQVTTSLIDSSMELFSSVFPFLNSKIQYSIMETLNLSMFSKMTTPLRSVAVAANVCSALHNALRIMQENNLELDYSVGQLIIESIKKIQFFNDIFLTKIKADCVGLLTAAIARTLGDEERQKFLTEQSRIFIKNVADMDEPYLRMFHVLSLATIFKYNSQYANFEEYFDVIFALMRDPHPVVHSWSLKAMHILLEKHLVIDLKTAALLLSSMEELLVQDKYGIYGRSTLRCNYNRDFNSHVAIGEISRTLTETVGPNFLELNTKVLDSFRNITLSMLISNNILNSITSIKMFENIATFKMKNILNYEIFILASKSIIKSSIVTGIGSSYFDTTFTGSNELISRTSSLKGAFENFDLLTLLYKLQMEEFFMKEMENLSWRYLALFPNSGSVKNYFTEWILHTFKRDNHWFDKLYSIFNMSLGRLFQSYNRDVSALLEVNGLKKSSEKEIKGEEEESIANVNQLTDTDAGGLDSENLQWKSRQIILNLILMLCLESEKYENLLLALSNKIADLIKISFRGSTVRNEGMKLTGLHILNFVLKNYSTMRDPQVPGSSILEQQEAQITSALMPAFSKGSSPTVMSFAITVAAEVLASNIMPPDKLGRISQLLIDLLGNFKDPNSGIRIGEAIIVTPKAKRKIELAVLDAWAEVVQRSITSSNDALFSFTRKYWSILVPLWIISLREYMMIKYNDNDSTVQVKNDSKENSLIEPRSTKIELYEPVWLNFVEALGCTLDSDVQVILASLNDEELEYFLFILFSQCLEAIVKNIDDHSVKMQVLPALHNVLKSNLCIKSIFEDDIITEVVEIMDRLISTGDSKEEFLLVDIISDLIIGYSKCNATPETFLQDIDKLYELLRLLMTIISERLPFIKYNVLTSEEDDNEIKISPTDISLLKKTFIAFESNISNFDNMFKVDLYSCLLFIIGKIYECSHREVIIPIILPLFKALVKALTESEDEKNIVLLEIFYGSIKDVIYHKLDSKNKVATILILLSNGYSKLSFQELNQCANILSEALNNPATQPIALQGFKRIISNIFKYPLLQYFMKLVIKRFFQDIQTNDSLSQASIKTKLIIQFSEEVIKQDHQKASLSIALCLSFFAAYHSAYTEKIDNEVASGIVALAKLDKNSFKEAISSTISPQQKAIIGSVMEAYVKSQSLGSVEEAFQLKSFD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 | Phosphorylation | DEFVRYISVLENTDD HHHHHHHHHHCCCCC | 16.24 | 27017623 | |
| 65 | Phosphorylation | YISVLENTDDLELHS HHHHHCCCCCCCHHH | 22.86 | 27017623 | |
| 76 | Phosphorylation | ELHSVFISLSQLYTI CHHHHEEEHHHHHEE | 15.54 | 27017623 | |
| 78 | Phosphorylation | HSVFISLSQLYTISI HHHEEEHHHHHEEEE | 16.02 | 27017623 | |
| 81 | Phosphorylation | FISLSQLYTISIWRL EEEHHHHHEEEEEEC | 8.39 | 27017623 | |
| 82 | Phosphorylation | ISLSQLYTISIWRLK EEHHHHHEEEEEECC | 19.48 | 27017623 | |
| 257 | Phosphorylation | WTAHFKQTNFIREHS HHHHHHHCCHHHHCC | 32.46 | 25533186 | |
| 428 | Phosphorylation | TYQSSSKSDSASNFK CCCCCCCCCCCCCCC | 38.45 | 28889911 | |
| 705 | Phosphorylation | VYLKLEKYINSDFNS HHHHHHHHHCCCCCC | 8.92 | 28132839 | |
| 877 | Phosphorylation | FLNSKIQYSIMETLN HHCCCHHHHHHHHCC | 12.02 | 28132839 | |
| 1546 | Ubiquitination | NDSTVQVKNDSKENS CCCCEEEECCCCCCC | 37.64 | 23749301 | |
| 1640 | Phosphorylation | KSNLCIKSIFEDDII HCCCHHHHHCCCCHH | 16.76 | 29688323 | |
| 1648 | Phosphorylation | IFEDDIITEVVEIMD HCCCCHHHHHHHHHH | 24.06 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LAA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LAA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LAA1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AP1G1_YEAST | APL4 | physical | 16687571 | |
| GGA2_YEAST | GGA2 | physical | 16687571 | |
| AP1B1_YEAST | APL2 | physical | 16687571 | |
| AP1G1_YEAST | APL4 | physical | 18467557 | |
| CHS5_YEAST | CHS5 | physical | 18467557 | |
| CLH_YEAST | CHC1 | genetic | 16687571 | |
| TRS20_YEAST | TRS20 | genetic | 27708008 | |
| ACT_YEAST | ACT1 | genetic | 27708008 | |
| CP51_YEAST | ERG11 | genetic | 27708008 | |
| ATC7_YEAST | NEO1 | genetic | 27708008 | |
| PAN1_YEAST | PAN1 | genetic | 27708008 | |
| CAP_YEAST | SRV2 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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