| UniProt ID | FRE6_YEAST | |
|---|---|---|
| UniProt AC | Q12473 | |
| Protein Name | Ferric reductase transmembrane component 6 | |
| Gene Name | FRE6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 712 | |
| Subcellular Localization |
Vacuole membrane Multi-pass membrane protein . |
|
| Protein Description | Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol.. | |
| Protein Sequence | MHRTLLFLTWLISLTKAFNIKLPHTEKKDHLESNAVLACASYINTLKWSFDSSVVPGFYSTICSYSPAFDTWSLCIFNSLTDQIIPMDNTSFEESLGNVRKTCSFVDKKFSNISLEQYYSSLNNASSHALEDYGSIESLSTSIRVDRETRSRWIRAFHAHAYNLDISSVYGAYLTYYFVIVGIIAVFFHMSHYNGLNRALFASRFVNYIRGHFVLPTFLVDKHANHFKFLNVEVFTGLMPNSLEAWIIFGYTLANIIFLSISYIIDPYNLIFNSHLSQFTRLLADRSGILAFTQFPLIIIFTARNSFLEFLTGVKFNSFISFHKWIGRIMVLNATIHSLSYSLFAIINHAFKISNKQLYWKFGIASITVLCVLLVLSLGIVRKRHYEFFLYTHIILALLFFYCCWQHVKIFNGWKEWIVVSLLIWGLEKLFRIWNILQFRFPKATLINLNTSNNPHDEMFKVIIPKYNRRWHSKPGQYCFIYFLHPLVFWQCHPFTIIDEGEKCVLVIKPKSGLTRFIYNHILQSLNGKLQLRVAIEGPYGPSNLHLDKFDHLLLLSGGTGLPGPLDHAIKLSRNPDKPKSIDLIMAIKNPSFLNGYKSEILELKNSRSHVNVQVYLTQKTAVTKAANARDQLIHFDDIMTELTSFAHIGNARPNFSNVIENAIKSTPPGDSLAVVCCGPPVLVDDVRNTVSQKLLGYPERIIEYFEEYQCW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 89 | N-linked_Glycosylation | DQIIPMDNTSFEESL CCEECCCCCCHHHHH | 31.22 | - | |
| 112 | N-linked_Glycosylation | FVDKKFSNISLEQYY HHCHHHCCCCHHHHH | 30.88 | - | |
| 124 | N-linked_Glycosylation | QYYSSLNNASSHALE HHHHHHCCCCCHHHH | 46.63 | - | |
| 359 | Phosphorylation | KISNKQLYWKFGIAS HCCCCHHHHHHCHHH | 12.21 | 21126336 | |
| 625 | Ubiquitination | TQKTAVTKAANARDQ EEHHHHHHHHHHHHH | 38.61 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FRE6_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FRE6_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FRE6_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RS8A_YEAST | RPS8A | genetic | 20093466 | |
| RS8B_YEAST | RPS8A | genetic | 20093466 | |
| IME1_YEAST | IME1 | genetic | 20093466 | |
| SAC1_YEAST | SAC1 | genetic | 20093466 | |
| EOS1_YEAST | EOS1 | genetic | 20093466 | |
| TCO89_YEAST | TCO89 | genetic | 20093466 | |
| BECN1_YEAST | VPS30 | genetic | 20093466 | |
| RS8A_YEAST | RPS8A | genetic | 27708008 | |
| RS8B_YEAST | RPS8A | genetic | 27708008 | |
| CSM1_YEAST | CSM1 | genetic | 27708008 | |
| CP56_YEAST | DIT2 | genetic | 27708008 | |
| MOG1_YEAST | MOG1 | genetic | 27708008 | |
| IME1_YEAST | IME1 | genetic | 27708008 | |
| RS21A_YEAST | RPS21A | genetic | 27708008 | |
| ACE2_YEAST | ACE2 | genetic | 27708008 | |
| UBX2_YEAST | UBX2 | genetic | 27708008 | |
| LSM7_YEAST | LSM7 | genetic | 27708008 | |
| HSP7F_YEAST | SSE1 | genetic | 27708008 | |
| BECN1_YEAST | VPS30 | genetic | 27708008 | |
| COX10_YEAST | COX10 | genetic | 27708008 | |
| BRR1_YEAST | BRR1 | genetic | 27708008 | |
| VPS4_YEAST | VPS4 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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