SUMT_YEAST - dbPTM
SUMT_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SUMT_YEAST
UniProt AC P36150
Protein Name Uroporphyrinogen-III C-methyltransferase
Gene Name MET1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 593
Subcellular Localization
Protein Description Siroheme synthase involved in methionine biosynthesis..
Protein Sequence MVRDLVTLPSSLPLITAGFATDQVHLLIGTGSTDSVSVCKNRIHSILNAGGNPIVVNPSSPSHTKQLQLEFGKFAKFEIVEREFRLSDLTTLGRVLVCKVVDRVFVDLPITQSRLCEEIFWQCQKLRIPINTFHKPEFSTFNMIPTWVDPKGSGLQISVTTNGNGYILANRIKRDIISHLPPNISEVVINMGYLKDRIINEDHKALLEEKYYQTDMSLPGFGYGLDEDGWESHKFNKLIREFEMTSREQRLKRTRWLSQIMEYYPMNKLSDIKLEDFETSSSPNKKTKQETVTEGVVPPTDENIENGTKQLQLSEVKKEEGPKKLGKISLVGSGPGSVSMLTIGALQEIKSADIILADKLVPQAILDLIPPKTETFIAKKFPGNAERAQQELLAKGLESLDNGLKVVRLKQGDPYIFGRGGEEFNFFKDHGYIPVVLPGISSSLACTVLAQIPATQRDIADQVLICTGTGRKGALPIIPEFVESRTTVFLMALHRANVLITGLLKHGWDGDVPAAIVERGSCPDQRVTRTLLKWVPEVVEEIGSRPPGVLVVGKAVNALVEKDLINFDESRKFVIDEGFREFEVDVDSLFKLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
60PhosphorylationPIVVNPSSPSHTKQL
EEEECCCCCCCCCEE		31.5117330950
65UbiquitinationPSSPSHTKQLQLEFG
CCCCCCCCEEEECCC		43.5217644757
99UbiquitinationLGRVLVCKVVDRVFV
HHHHHHEEECCEEEC		37.5017644757
125UbiquitinationEIFWQCQKLRIPINT
HHHHHHHCCCCCCCC		47.5717644757
166PhosphorylationVTTNGNGYILANRIK
EEECCCCEEEEEEEC		9.2129688323
195UbiquitinationVINMGYLKDRIINED
EEECCHHHHHHCCCH		36.1617644757
268UbiquitinationMEYYPMNKLSDIKLE
HHHCCCCCCCCCCHH		43.0217644757
273UbiquitinationMNKLSDIKLEDFETS
CCCCCCCCHHHCCCC		51.3017644757
279PhosphorylationIKLEDFETSSSPNKK
CCHHHCCCCCCCCCC		33.6228889911
280PhosphorylationKLEDFETSSSPNKKT
CHHHCCCCCCCCCCC		22.9428889911
281PhosphorylationLEDFETSSSPNKKTK
HHHCCCCCCCCCCCC		58.1824603354
282PhosphorylationEDFETSSSPNKKTKQ
HHCCCCCCCCCCCCC		32.0625752575
285UbiquitinationETSSSPNKKTKQETV
CCCCCCCCCCCCEEE		66.2717644757
286UbiquitinationTSSSPNKKTKQETVT
CCCCCCCCCCCEEEC		68.5417644757
288UbiquitinationSSPNKKTKQETVTEG
CCCCCCCCCEEECCC		55.8317644757
309UbiquitinationENIENGTKQLQLSEV
CCCCCCCEEEEHHHH		50.8617644757
317UbiquitinationQLQLSEVKKEEGPKK
EEEHHHHCHHHCCCC		50.8717644757
318UbiquitinationLQLSEVKKEEGPKKL
EEHHHHCHHHCCCCC		67.2017644757
327UbiquitinationEGPKKLGKISLVGSG
HCCCCCCEEEEECCC		39.2917644757
350UbiquitinationIGALQEIKSADIILA
HHHHHHHHCCCEEEC		38.5517644757
359UbiquitinationADIILADKLVPQAIL
CCEEECCCCHHHHHH		45.8617644757
372UbiquitinationILDLIPPKTETFIAK
HHHHCCCCCCEEEEC		54.3517644757
379UbiquitinationKTETFIAKKFPGNAE
CCCEEEECCCCCCHH		50.5617644757
380UbiquitinationTETFIAKKFPGNAER
CCEEEECCCCCCHHH		48.0117644757
395UbiquitinationAQQELLAKGLESLDN
HHHHHHHHHHHHCCC		65.0917644757
405UbiquitinationESLDNGLKVVRLKQG
HHCCCCCEEEEECCC		39.8317644757
428UbiquitinationGEEFNFFKDHGYIPV
CCCCCCCCCCCCCEE		44.6817644757
472UbiquitinationICTGTGRKGALPIIP
EECCCCCCCCCCCCH		50.2917644757
505UbiquitinationVLITGLLKHGWDGDV
HHHHHHHHCCCCCCC		45.1517644757
533UbiquitinationRVTRTLLKWVPEVVE
HHHHHHHHHHHHHHH		49.6217644757
554UbiquitinationPGVLVVGKAVNALVE
CEEEEECHHHHHHHH		37.2417644757
562UbiquitinationAVNALVEKDLINFDE
HHHHHHHHCCCCCCH		50.8117644757
572UbiquitinationINFDESRKFVIDEGF
CCCCHHCCEEECCCC		53.9417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SUMT_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SUMT_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SUMT_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV161_YEASTRVS161genetic
27708008
GPR1_YEASTGPR1genetic
27708008
INO2_YEASTINO2genetic
27708008
RV167_YEASTRVS167genetic
27708008
SHE9_YEASTSHE9genetic
27708008
PPB_YEASTPHO8genetic
27708008
TFS2_YEASTDST1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
ADE_YEASTAAH1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SUMT_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.

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