| UniProt ID | PYC1_YEAST | |
|---|---|---|
| UniProt AC | P11154 | |
| Protein Name | Pyruvate carboxylase 1 | |
| Gene Name | PYC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1178 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.. | |
| Protein Sequence | MSQRKFAGLRDNFNLLGEKNKILVANRGEIPIRIFRTAHELSMQTVAIYSHEDRLSTHKQKADEAYVIGEVGQYTPVGAYLAIDEIISIAQKHQVDFIHPGYGFLSENSEFADKVVKAGITWIGPPAEVIDSVGDKVSARNLAAKANVPTVPGTPGPIETVEEALDFVNEYGYPVIIKAAFGGGGRGMRVVREGDDVADAFQRATSEARTAFGNGTCFVERFLDKPKHIEVQLLADNHGNVVHLFERDCSVQRRHQKVVEVAPAKTLPREVRDAILTDAVKLAKECGYRNAGTAEFLVDNQNRHYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGASLPQLGLFQDKITTRGFAIQCRITTEDPAKNFQPDTGRIEVYRSAGGNGVRLDGGNAYAGTIISPHYDSMLVKCSCSGSTYEIVRRKMIRALIEFRIRGVKTNIPFLLTLLTNPVFIEGTYWTTFIDDTPQLFQMVSSQNRAQKLLHYLADVAVNGSSIKGQIGLPKLKSNPSVPHLHDAQGNVINVTKSAPPSGWRQVLLEKGPAEFARQVRQFNGTLLMDTTWRDAHQSLLATRVRTHDLATIAPTTAHALAGRFALECWGGATFDVAMRFLHEDPWERLRKLRSLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVKQAKDNGVDIFRVFDALNDLEQLKVGVDAVKKAGGVVEATVCFSGDMLQPGKKYNLDYYLEIAEKIVQMGTHILGIKDMAGTMKPAAAKLLIGSLRAKYPDLPIHVHTHDSAGTAVASMTACALAGADVVDVAINSMSGLTSQPSINALLASLEGNIDTGINVEHVRELDAYWAEMRLLYSCFEADLKGPDPEVYQHEIPGGQLTNLLFQAQQLGLGEQWAETKRAYREANYLLGDIVKVTPTSKVVGDLAQFMVSNKLTSDDVRRLANSLDFPDSVMDFFEGLIGQPYGGFPEPFRSDVLRNKRRKLTCRPGLELEPFDLEKIREDLQNRFGDVDECDVASYNMYPRVYEDFQKMRETYGDLSVLPTRSFLSPLETDEEIEVVIEQGKTLIIKLQAVGDLNKKTGEREVYFDLNGEMRKIRVADRSQKVETVTKSKADMHDPLHIGAPMAGVIVEVKVHKGSLIKKGQPVAVLSAMKMEMIISSPSDGQVKEVFVSDGENVDSSDLLVLLEDQVPVETKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Succinylation | NFNLLGEKNKILVAN CCHHHCCCCEEEEEC | 62.84 | 23954790 | |
| 21 | Ubiquitination | NLLGEKNKILVANRG HHHCCCCEEEEECCC | 48.78 | 23749301 | |
| 114 | Acetylation | ENSEFADKVVKAGIT CCHHHHHHHHHCCCE | 45.56 | 24489116 | |
| 136 | Acetylation | VIDSVGDKVSARNLA HHHCCCCHHHHHHHH | 31.96 | 24489116 | |
| 227 | Ubiquitination | ERFLDKPKHIEVQLL EECCCCCCEEEEEEE | 64.06 | 17644757 | |
| 257 | Ubiquitination | SVQRRHQKVVEVAPA CCHHHHHHEEEECCC | 41.97 | 23749301 | |
| 265 | Ubiquitination | VVEVAPAKTLPREVR EEEECCCCCCCHHHH | 49.92 | 23749301 | |
| 281 | Acetylation | AILTDAVKLAKECGY HHHHHHHHHHHHHCC | 44.43 | 24489116 | |
| 281 | Ubiquitination | AILTDAVKLAKECGY HHHHHHHHHHHHHCC | 44.43 | 17644757 | |
| 483 | Ubiquitination | SSQNRAQKLLHYLAD HCCHHHHHHHHHHHH | 52.62 | 24961812 | |
| 483 | Acetylation | SSQNRAQKLLHYLAD HCCHHHHHHHHHHHH | 52.62 | 24489116 | |
| 506 | Acetylation | KGQIGLPKLKSNPSV CCCCCCCCCCCCCCC | 73.85 | 24489116 | |
| 508 | Ubiquitination | QIGLPKLKSNPSVPH CCCCCCCCCCCCCCC | 55.07 | 24961812 | |
| 509 | Phosphorylation | IGLPKLKSNPSVPHL CCCCCCCCCCCCCCC | 65.49 | 22369663 | |
| 512 | Phosphorylation | PKLKSNPSVPHLHDA CCCCCCCCCCCCCCC | 53.16 | 22369663 | |
| 527 | Phosphorylation | QGNVINVTKSAPPSG CCCEEEECCCCCCCC | 18.13 | 22369663 | |
| 528 | Ubiquitination | GNVINVTKSAPPSGW CCEEEECCCCCCCCC | 40.10 | 17644757 | |
| 528 | Acetylation | GNVINVTKSAPPSGW CCEEEECCCCCCCCC | 40.10 | 24489116 | |
| 542 | Acetylation | WRQVLLEKGPAEFAR CHHHHHHCCHHHHHH | 70.89 | 24489116 | |
| 658 | Ubiquitination | NAIDHFVKQAKDNGV HHHHHHHHHHHHCCC | 43.52 | 17644757 | |
| 658 | Acetylation | NAIDHFVKQAKDNGV HHHHHHHHHHHHCCC | 43.52 | 24489116 | |
| 661 | Ubiquitination | DHFVKQAKDNGVDIF HHHHHHHHHCCCCHH | 49.59 | 23749301 | |
| 681 | Ubiquitination | LNDLEQLKVGVDAVK HCCHHHHHCCHHHHH | 36.32 | 17644757 | |
| 734 | Acetylation | GTHILGIKDMAGTMK CCHHCCCCCCCCCCC | 39.39 | 24489116 | |
| 734 | N6-carboxylysine | GTHILGIKDMAGTMK CCHHCCCCCCCCCCC | 39.39 | - | |
| 734 | Succinylation | GTHILGIKDMAGTMK CCHHCCCCCCCCCCC | 39.39 | 23954790 | |
| 734 | Carboxylation | GTHILGIKDMAGTMK CCHHCCCCCCCCCCC | 39.39 | - | |
| 741 | Ubiquitination | KDMAGTMKPAAAKLL CCCCCCCCHHHHHHH | 31.20 | 23749301 | |
| 746 | Acetylation | TMKPAAAKLLIGSLR CCCHHHHHHHHHHHH | 38.82 | 24489116 | |
| 829 | Phosphorylation | HVRELDAYWAEMRLL HHHHHHHHHHHHHHH | 12.57 | 22369663 | |
| 896 | Acetylation | YLLGDIVKVTPTSKV HHHCCCEECCCCCHH | 40.50 | 24489116 | |
| 896 | Ubiquitination | YLLGDIVKVTPTSKV HHHCCCEECCCCCHH | 40.50 | 17644757 | |
| 900 | Phosphorylation | DIVKVTPTSKVVGDL CCEECCCCCHHHHHH | 31.64 | 23749301 | |
| 902 | Ubiquitination | VKVTPTSKVVGDLAQ EECCCCCHHHHHHHH | 43.34 | 23749301 | |
| 966 | Phosphorylation | RNKRRKLTCRPGLEL HHCCCCCCCCCCCCC | 14.98 | 21440633 | |
| 1092 | 2-Hydroxyisobutyrylation | QKVETVTKSKADMHD CCEEEECCCCCCCCC | 45.69 | - | |
| 1135 | Lipoylation | VAVLSAMKMEMIISS EEEEEEEEEEEEEEC | 31.27 | 3042770 | |
| 1135 | Biotinylation | VAVLSAMKMEMIISS EEEEEEEEEEEEEEC | 31.27 | 3042770 | |
| 1135 | N6-biotinyllysine | VAVLSAMKMEMIISS EEEEEEEEEEEEEEC | 31.27 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PYC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PYC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PYC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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