GAT1_YEAST - dbPTM
GAT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAT1_YEAST
UniProt AC P43574
Protein Name Transcriptional regulatory protein GAT1
Gene Name GAT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 510
Subcellular Localization Nucleus .
Protein Description Positive regulator of multiple nitrogen catabolic genes..
Protein Sequence MHVFFPLLFRPSPVLFIACAYIYIDIYIHCTRCTVVNITMSTNRVPNLDPDLNLNKEIWDLYSSAQKILPDSNRILNLSWRLHNRTSFHRINRIMQHSNSIMDFSASPFASGVNAAGPGNNDLDDTDTDNQQFFLSDMNLNGSSVFENVFDDDDDDDDVETHSIVHSDLLNDMDSASQRASHNASGFPNFLDTSCSSSFDDHFIFTNNLPFLNNNSINNNHSHNSSHNNNSPSIANNTNANTNTNTSASTNTNSPLLRRNPSPSIVKPGSRRNSSVRKKKPALKKIKSSTSVQSSATPPSNTSSNPDIKCSNCTTSTTPLWRKDPKGLPLCNACGLFLKLHGVTRPLSLKTDIIKKRQRSSTKINNNITPPPSSSLNPGAAGKKKNYTASVAASKRKNSLNIVAPLKSQDIPIPKIASPSIPQYLRSNTRHHLSSSVPIEAETFSSFRPDMNMTMNMNLHNASTSSFNNEAFWKPLDSAIDHHSGDTNPNSNMNTTPNGNLSLDWLNLNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
64PhosphorylationEIWDLYSSAQKILPD
HHHHHHHHHHHHCCC		22.5925371407
167PhosphorylationETHSIVHSDLLNDMD
HHHHHHCHHHHCCCC		21.0428889911
254PhosphorylationSASTNTNSPLLRRNP
CCCCCCCCCCHHCCC		18.1927214570
262PhosphorylationPLLRRNPSPSIVKPG
CCHHCCCCCCCCCCC		34.5222369663
264PhosphorylationLRRNPSPSIVKPGSR
HHCCCCCCCCCCCCC		44.3322369663
270PhosphorylationPSIVKPGSRRNSSVR
CCCCCCCCCCCHHHH		36.2722369663
288PhosphorylationPALKKIKSSTSVQSS
HHHHHHHCCCCCCCC		42.1822369663
289PhosphorylationALKKIKSSTSVQSSA
HHHHHHCCCCCCCCC		21.5022369663
290PhosphorylationLKKIKSSTSVQSSAT
HHHHHCCCCCCCCCC		39.7522369663
291PhosphorylationKKIKSSTSVQSSATP
HHHHCCCCCCCCCCC		21.8022369663
294PhosphorylationKSSTSVQSSATPPSN
HCCCCCCCCCCCCCC		21.5622369663
295PhosphorylationSSTSVQSSATPPSNT
CCCCCCCCCCCCCCC		21.0422369663
297PhosphorylationTSVQSSATPPSNTSS
CCCCCCCCCCCCCCC		37.3720377248
300PhosphorylationQSSATPPSNTSSNPD
CCCCCCCCCCCCCCC		54.6822369663
302PhosphorylationSATPPSNTSSNPDIK
CCCCCCCCCCCCCCC		37.5622369663
303PhosphorylationATPPSNTSSNPDIKC
CCCCCCCCCCCCCCC		32.1622369663
304PhosphorylationTPPSNTSSNPDIKCS
CCCCCCCCCCCCCCC		50.7920377248
314PhosphorylationDIKCSNCTTSTTPLW
CCCCCCCCCCCCCCC		28.2127017623
318PhosphorylationSNCTTSTTPLWRKDP
CCCCCCCCCCCCCCC		19.0227017623
326UbiquitinationPLWRKDPKGLPLCNA
CCCCCCCCCCCCCHH		81.0717644757
339UbiquitinationNACGLFLKLHGVTRP
HHHHHHHHHCCCCCC		30.9717644757
348PhosphorylationHGVTRPLSLKTDIIK
CCCCCCCCCCHHHHH		30.4223749301
350UbiquitinationVTRPLSLKTDIIKKR
CCCCCCCCHHHHHHH		40.5523749301
351PhosphorylationTRPLSLKTDIIKKRQ
CCCCCCCHHHHHHHH		37.4123749301
360PhosphorylationIIKKRQRSSTKINNN
HHHHHHHCCCCCCCC		33.7428889911
361PhosphorylationIKKRQRSSTKINNNI
HHHHHHCCCCCCCCC		35.5921082442
369PhosphorylationTKINNNITPPPSSSL
CCCCCCCCCCCCCCC		31.6919823750
373PhosphorylationNNITPPPSSSLNPGA
CCCCCCCCCCCCCCC		38.0329136822
374PhosphorylationNITPPPSSSLNPGAA
CCCCCCCCCCCCCCC		44.6229136822
375PhosphorylationITPPPSSSLNPGAAG
CCCCCCCCCCCCCCC		36.1829136822
399PhosphorylationAASKRKNSLNIVAPL
HHHCCCCCCCEEEEC		26.3122369663
418PhosphorylationIPIPKIASPSIPQYL
CCCCCCCCCCHHHHH		23.7422369663
420PhosphorylationIPKIASPSIPQYLRS
CCCCCCCCHHHHHHC		44.3922369663
424PhosphorylationASPSIPQYLRSNTRH
CCCCHHHHHHCCCCH		9.9522369663
427PhosphorylationSIPQYLRSNTRHHLS
CHHHHHHCCCCHHCC		39.7019795423
429PhosphorylationPQYLRSNTRHHLSSS
HHHHHCCCCHHCCCC		32.4019795423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GAT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BMH2_YEASTBMH2genetic
14673167
CDC25_YEASTCDC25genetic
14673167
RAS2_YEASTRAS2genetic
14673167
SOK1_YEASTSOK1genetic
14673167
KAPA_YEASTTPK1genetic
14673167
URE2_YEASTURE2genetic
10799523
URE2_YEASTURE2physical
18467557
GLN3_YEASTGLN3genetic
19104072
HMO1_YEASTHMO1genetic
20959818
CBF1_YEASTCBF1genetic
20959818
UBP8_YEASTUBP8genetic
20959818
ISW2_YEASTISW2genetic
20959818
GLN3_YEASTGLN3genetic
20959818
GLN3_YEASTGLN3genetic
22169538
URE2_YEASTURE2physical
22615397
LST4_YEASTLST4genetic
24415948
GLN3_YEASTGLN3genetic
26419331
NUP60_YEASTNUP60genetic
27708008
TPS1_YEASTTPS1genetic
27708008
KCC4_YEASTKCC4genetic
27708008
RV161_YEASTRVS161genetic
27708008
YCY0_YEASTYCR090Cgenetic
27708008
RLA3_YEASTRPP1Bgenetic
27708008
RPA14_YEASTRPA14genetic
27708008
MNN10_YEASTMNN10genetic
27708008
RAD4_YEASTRAD4genetic
27708008
ITC1_YEASTITC1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
THI4_YEASTTHI4genetic
27708008
UBA4_YEASTUBA4genetic
27708008
RIM11_YEASTRIM11genetic
27708008
RAD14_YEASTRAD14genetic
27708008
RM44_YEASTMRPL44genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
IZH2_YEASTIZH2genetic
27708008
RTC1_YEASTRTC1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-262; THR-369AND SER-418, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-399 ANDSER-418, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418, AND MASSSPECTROMETRY.

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