YO283_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YO283_YEAST
• UniProt AC: Q12040
• Protein Name: Broad-specificity phosphatase YOR283W
• Gene Name: YOR283W
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 230
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates..
• Protein Sequence: MTKEVPYYCDNDDNNIIRLFIIRHGQTEHNVKKILQGHKDTSINPTGEEQATKLGHYLRSRGIHFDKVVSSDLKRCRQTTALVLKHSKQENVPTSYTSGLRERYMGVIEGMQITEAEKYADKHGEGSFRNFGEKSDDFVARLTGCVEEEVAEASNEGVKNLALVSHGGAIRMILQWLKYENHQAHKIIVFNTSVTIVDYVKDSKQFIVRRVGNTQHLGDGEFVVSDLRLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTKEVPYYC ------CCCCCCEEE	35.59	30377154
3	Ubiquitination	-----MTKEVPYYCD -----CCCCCCEEEC	56.25	17644757
7	Phosphorylation	-MTKEVPYYCDNDDN -CCCCCCEEECCCCC	23.15	30377154
8	Phosphorylation	MTKEVPYYCDNDDNN CCCCCCEEECCCCCC	6.30	30377154
27	Phosphorylation	FIIRHGQTEHNVKKI EEEECCCCHHHHHHH	43.75	23749301
32	Ubiquitination	GQTEHNVKKILQGHK CCCHHHHHHHHCCCC	39.14	17644757
33	Ubiquitination	QTEHNVKKILQGHKD CCHHHHHHHHCCCCC	44.35	17644757
39	Ubiquitination	KKILQGHKDTSINPT HHHHCCCCCCCCCCC	70.31	17644757
39	Acetylation	KKILQGHKDTSINPT HHHHCCCCCCCCCCC	70.31	24489116
53	Acetylation	TGEEQATKLGHYLRS CCHHHHHHHHHHHHH	56.33	24489116
53	Ubiquitination	TGEEQATKLGHYLRS CCHHHHHHHHHHHHH	56.33	17644757
67	Ubiquitination	SRGIHFDKVVSSDLK HCCCCCHHHHCHHHH	43.52	24961812
74	Acetylation	KVVSSDLKRCRQTTA HHHCHHHHHHHHHHH	55.21	25381059
85	Ubiquitination	QTTALVLKHSKQENV HHHHHHHHCCCCCCC	38.05	17644757
88	Ubiquitination	ALVLKHSKQENVPTS HHHHHCCCCCCCCCC	62.44	17644757
88	Acetylation	ALVLKHSKQENVPTS HHHHHCCCCCCCCCC	62.44	24489116
118	Acetylation	MQITEAEKYADKHGE EEEEEHHHHHHHCCC	53.43	24489116
118	Ubiquitination	MQITEAEKYADKHGE EEEEEHHHHHHHCCC	53.43	22817900
122	Acetylation	EAEKYADKHGEGSFR EHHHHHHHCCCCCCC	45.39	24489116
122	Ubiquitination	EAEKYADKHGEGSFR EHHHHHHHCCCCCCC	45.39	24961812
127	Phosphorylation	ADKHGEGSFRNFGEK HHHCCCCCCCCCCCC	19.41	19795423
134	Acetylation	SFRNFGEKSDDFVAR CCCCCCCCCHHHHHH	60.61	24489116
134	Ubiquitination	SFRNFGEKSDDFVAR CCCCCCCCCHHHHHH	60.61	17644757
154	Phosphorylation	EEEVAEASNEGVKNL HHHHHHHHHHHHCCE	27.24	28889911
159	Ubiquitination	EASNEGVKNLALVSH HHHHHHHCCEEEEEC	58.04	23749301
178	Ubiquitination	RMILQWLKYENHQAH HHHHHHHHHCCCCCC	47.78	22817900
225	Phosphorylation	GDGEFVVSDLRLR-- CCCEEEEEECCCC--	26.14	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YO283_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YO283_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YO283_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WTM2_YEAST	WTM2	physical	18719252
BUD27_YEAST	BUD27	genetic	20093466
F26_YEAST	FBP26	genetic	20093466
IOC4_YEAST	IOC4	genetic	20093466
SWF1_YEAST	SWF1	genetic	27708008
RLA4_YEAST	RPP2B	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
BUB1_YEAST	BUB1	genetic	27708008
F26_YEAST	FBP26	genetic	27708008
RTG1_YEAST	RTG1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.