DHR1_YEAST - dbPTM
DHR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHR1_YEAST
UniProt AC Q04217
Protein Name Probable ATP-dependent RNA helicase DHR1
Gene Name ECM16
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1267
Subcellular Localization Nucleus, nucleolus .
Protein Description Probable ATP-binding RNA helicase. Required for 18S rRNA synthesis. May play a role in restructuring of the pre-rRNA..
Protein Sequence MGTYRKRFNEKARSGHMAKLKELKRIRNKQFTRQDENDERVENPDSAPAESSTTEPNANAEILEPLTEEEKKMKKRKLQELFTPKESKVSRLKKKRLDKFIEHQLKREERKTIIGKLQDYKIDTSLLTSSKRLGEGRQTKKEEFKEALSLERQGRGNEQTNEILYEEYEPKVWDEYGEGGSSEDDDGEDDFEASFGSMPKPTDNEEKKSSGFIDHRPAKFGGSGLSFGFSNIKVINKESKTPKKKYNWRQRVEMEELKKHGKEDEMDFDTTSEDDDEEEDQEEEDKMHPSENPLEEVESADSETGSEKFDQNDVANEFKDWANQEIKKLEGRDQELVTPTLNIDYKPIIRKEDLDDGLQEAYVPINENSTRKAFYVEVSRSDEIQKARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGMVGITQPRRVAAVSMAERVANELGDHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLTKYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTLFPIAPPVLQVDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEITHMVKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGNSGNGEDEEDEEEEGFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRKPNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFLRGKLMEEIVKLRKQLMYIIKSNTSKENIAVVIRNEDLKSDIPSVIQIKLLKQMICAGFVDHVAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLGEMPPKYMLYYSLHLGGNNKTRMNTLCDIASTPLANIARKGLLLTYSKPLTGQGLKTVNLSPTERYCYVVPRFGSTVDNDLKIGWDLNPIAVHQKKQKGQWTVIKFITRKGFQTITGEEKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19AcetylationARSGHMAKLKELKRI
HHHCHHHHHHHHHHH		53.1425381059
85AcetylationLQELFTPKESKVSRL
HHHHCCCCHHHHHHH		72.1224489116
99AcetylationLKKKRLDKFIEHQLK
HHHHHHHHHHHHHHH		53.4822865919
106AcetylationKFIEHQLKREERKTI
HHHHHHHHHHHHHHH		51.7125381059
116AcetylationERKTIIGKLQDYKID
HHHHHHHHHHCCCCC		32.3524489116
121AcetylationIGKLQDYKIDTSLLT
HHHHHCCCCCHHHHH		42.2524489116
124PhosphorylationLQDYKIDTSLLTSSK
HHCCCCCHHHHHCCC		25.4230377154
125PhosphorylationQDYKIDTSLLTSSKR
HCCCCCHHHHHCCCC		20.0321551504
128PhosphorylationKIDTSLLTSSKRLGE
CCCHHHHHCCCCCCC		35.9330377154
129PhosphorylationIDTSLLTSSKRLGEG
CCHHHHHCCCCCCCC		33.5630377154
130PhosphorylationDTSLLTSSKRLGEGR
CHHHHHCCCCCCCCC		19.2930377154
131AcetylationTSLLTSSKRLGEGRQ
HHHHHCCCCCCCCCC		51.9525381059
149PhosphorylationEEFKEALSLERQGRG
HHHHHHHHHHHCCCC		34.9230377154
176PhosphorylationEPKVWDEYGEGGSSE
CCCCCCCCCCCCCCC		20.2928889911
181PhosphorylationDEYGEGGSSEDDDGE
CCCCCCCCCCCCCCC		41.2221440633
182PhosphorylationEYGEGGSSEDDDGED
CCCCCCCCCCCCCCC		48.6021440633
194PhosphorylationGEDDFEASFGSMPKP
CCCCCHHHCCCCCCC		23.9621440633
197PhosphorylationDFEASFGSMPKPTDN
CCHHHCCCCCCCCCC		29.8721440633
202PhosphorylationFGSMPKPTDNEEKKS
CCCCCCCCCCHHHHH		58.5421440633
219AcetylationFIDHRPAKFGGSGLS
CCCCCCCHHCCCCEE		47.4224489116
223PhosphorylationRPAKFGGSGLSFGFS
CCCHHCCCCEEECCC		36.6221440633
226PhosphorylationKFGGSGLSFGFSNIK
HHCCCCEEECCCCEE		27.1830377154
237AcetylationSNIKVINKESKTPKK
CCEEEECCCCCCCCC		52.8425381059
270PhosphorylationEDEMDFDTTSEDDDE
CCCCCCCCCCCCCCH		32.0121440633
271PhosphorylationDEMDFDTTSEDDDEE
CCCCCCCCCCCCCHH		31.7819795423
272PhosphorylationEMDFDTTSEDDDEEE
CCCCCCCCCCCCHHH		40.9119795423
290PhosphorylationEEDKMHPSENPLEEV
HHHHCCCCCCHHHHH		35.0127017623
299PhosphorylationNPLEEVESADSETGS
CHHHHHHHCCCCCCC		42.4220377248
302PhosphorylationEEVESADSETGSEKF
HHHHHCCCCCCCCCC		36.4520377248
304PhosphorylationVESADSETGSEKFDQ
HHHCCCCCCCCCCCH		50.3821440633
306PhosphorylationSADSETGSEKFDQND
HCCCCCCCCCCCHHH		45.0621440633
338PhosphorylationGRDQELVTPTLNIDY
CCCCCCCCCCCCCCC		24.1525752575
340PhosphorylationDQELVTPTLNIDYKP
CCCCCCCCCCCCCCC		24.0729688323
345PhosphorylationTPTLNIDYKPIIRKE
CCCCCCCCCCCCCHH		18.1829688323
346AcetylationPTLNIDYKPIIRKED
CCCCCCCCCCCCHHH		26.4524489116
508PhosphorylationMMHDFKLTKYSSIII
HHHHHCCCCCEEEEE		28.6423607784
525PhosphorylationAHERNINTDILIGML
HHHCCCCHHHHHHHH		22.1828889911
999AcetylationSQFSKLDKFSDVFRL
HHHHCHHHHHHHHHH		58.1522865919
1018AcetylationSAMDYVPKEQKEIFM
HHHHCCCHHHHHHHH		63.8324489116
1192AcetylationGLLLTYSKPLTGQGL
CEEEEECCCCCCCCC		33.3624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DHR1_YEASTECM16physical
14759368
PHO23_YEASTPHO23physical
11805826
SDS3_YEASTSDS3physical
11805826
UME1_YEASTUME1physical
11805826
BUD23_YEASTBUD23physical
16554755
ASF2_YEASTASF2physical
16554755
YRA1_YEASTYRA1physical
16554755
RPF2_YEASTRPF2physical
16554755
TR112_YEASTTRM112physical
16554755
RRS1_YEASTRRS1physical
16554755
NOC2_YEASTNOC2physical
16554755
PHO23_YEASTPHO23physical
16429126
RRP5_YEASTRRP5physical
16429126
SDS3_YEASTSDS3physical
16429126
UME1_YEASTUME1physical
16429126
MSN5_YEASTMSN5genetic
19061648
CSK2C_YEASTCKB2genetic
19061648
UAF30_YEASTUAF30genetic
19061648
GFD1_YEASTGFD1genetic
19061648
TMA23_YEASTTMA23genetic
19061648
SYDM_YEASTMSD1genetic
19061648
NOT4_YEASTMOT2genetic
19061648
TCPQ_YEASTCCT8physical
19536198
HSP72_YEASTSSA2physical
19536198
HSP71_YEASTSSA1physical
19536198
SSB1_YEASTSSB1physical
19536198
MPP10_YEASTMPP10physical
16449634
BUD23_YEASTBUD23physical
24710271
UTP14_YEASTUTP14physical
26729466
UTP14_YEASTUTP14genetic
26729466
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHR1_YEAST

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Related Literatures of Post-Translational Modification

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