dbPTM

HSP31_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSP31_YEAST
UniProt AC	Q04432
Protein Name	Glutathione-independent glyoxalase HSP31 {ECO:0000303\|PubMed:24302734}
Gene Name	HSP31 {ECO:0000303\|PubMed:14745011}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	237
Subcellular Localization	Cytoplasm, P-body . Present in processing bodies (P-bodies) and stress granule (SG) foci upon glucose starvation and heat shock.
Protein Description	Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. [PubMed: 24302734 Involved in protection against reactive oxygen species (ROS)]
Protein Sequence	MAPKKVLLALTSYNDVFYSDGAKTGVFVVEALHPFNTFRKEGFEVDFVSETGKFGWDEHSLAKDFLNGQDETDFKNKDSDFNKTLAKIKTPKEVNADDYQIFFASAGHGTLFDYPKAKDLQDIASEIYANGGVVAAVCHGPAIFDGLTDKKTGRPLIEGKSITGFTDVGETILGVDSILKAKNLATVEDVAKKYGAKYLAPVGPWDDYSITDGRLVTGVNPASAHSTAVRSIDALKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Acetylation	GQDETDFKNKDSDFN CCCCCCCCCCCCCHH	66.93	24489116
77	Acetylation	DETDFKNKDSDFNKT CCCCCCCCCCCHHHH	60.23	24489116
138	Oxidation	GGVVAAVCHGPAIFD CCEEEEEEECCHHHC	2.35	14745011
197	Acetylation	VAKKYGAKYLAPVGP HHHHHCCEEEECCCC	36.11	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HSP31_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSP31_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSP31_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC3_YEAST	CDC3	physical	16554755
SNO4_YEAST	SNO4	physical	16554755
HSP31_YEAST	HSP31	physical	14745011
PP4R2_YEAST	PSY4	physical	19536198
SRS2_YEAST	SRS2	genetic	21459050
HSP32_YEAST	HSP32	genetic	24706893
HSP33_YEAST	HSP33	genetic	24706893
SNO4_YEAST	SNO4	genetic	24706893
VAM6_YEAST	VAM6	genetic	27708008
BUD14_YEAST	BUD14	genetic	27708008
SHG1_YEAST	SHG1	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
RV161_YEAST	RVS161	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
MAF1_YEAST	MAF1	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
BCS1_YEAST	BCS1	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
YGY5_YEAST	YGL235W	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
YG2W_YEAST	YGR111W	genetic	27708008
DOT5_YEAST	DOT5	genetic	27708008
BBC1_YEAST	BBC1	genetic	27708008
CYP7_YEAST	CPR7	genetic	27708008
PTK2_YEAST	PTK2	genetic	27708008
EMC2_YEAST	EMC2	genetic	27708008
HAP4_YEAST	HAP4	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
COA4_YEAST	COA4	genetic	27708008
VRP1_YEAST	VRP1	genetic	27708008
VID22_YEAST	VID22	genetic	27708008
OSW5_YEAST	OSW5	genetic	27708008
SSO2_YEAST	SSO2	genetic	27708008
AEP2_YEAST	AEP2	genetic	27708008
BEM4_YEAST	BEM4	genetic	27708008
COX10_YEAST	COX10	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
UBR1_YEAST	UBR1	genetic	26466368
HSP71_YEAST	SSA1	genetic	26466368
HS104_YEAST	HSP104	physical	27690738

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSP31_YEAST

Related Literatures of Post-Translational Modification