| UniProt ID | HSP33_YEAST | |
|---|---|---|
| UniProt AC | Q08914 | |
| Protein Name | Probable glutathione-independent glyoxalase HSP33 {ECO:0000250|UniProtKB:Q04432} | |
| Gene Name | HSP33 {ECO:0000303|PubMed:14745011} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 237 | |
| Subcellular Localization | Cytoplasm, P-body . Present in processing bodies (P-bodies) and stress granule (SG) foci upon glucose starvation and heat shock. | |
| Protein Description | Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation. [PubMed: 24706893] | |
| Protein Sequence | MTPKRALISLTSYHGPFYKDGAKTGVFVVEILRSFDTFEKHGFEVDFVSETGGFGWDEHYLPKSFIGGEDKMNFETKNSAFNKALARIKTANEVNASDYKVFFASAGHGALFDYPKAKNLQDIASKIYANGGVIAAICHGPLLFDGLIDIKTTRPLIEGKAITGFPLEGEIALGVDDILRSRKLTTVERVANKNGAKYLAPIHPWDDYSITDGKLVTGVNANSSYSTTIRAINALYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of HSP33_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSP33_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSP33_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSP33_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HSP33_YEAST | HSP33 | physical | 21139195 | |
| MED6_YEAST | MED6 | genetic | 27708008 | |
| BET3_YEAST | BET3 | genetic | 27708008 | |
| HAP3_YEAST | HAP3 | genetic | 27708008 | |
| BRE1_YEAST | BRE1 | genetic | 27708008 | |
| HUR1_YEAST | HUR1 | genetic | 27708008 | |
| ASK10_YEAST | ASK10 | genetic | 27708008 | |
| ATG27_YEAST | ATG27 | genetic | 27708008 | |
| IRS4_YEAST | IRS4 | genetic | 27708008 | |
| YL271_YEAST | YLR271W | genetic | 27708008 | |
| MSC1_YEAST | MSC1 | genetic | 27708008 | |
| AEP2_YEAST | AEP2 | genetic | 27708008 | |
| ATP23_YEAST | ATP23 | genetic | 27708008 | |
| HMI1_YEAST | HMI1 | genetic | 27708008 | |
| CY1_YEAST | CYT1 | genetic | 27708008 | |
| COQ7_YEAST | CAT5 | genetic | 27708008 | |
| COX10_YEAST | COX10 | genetic | 27708008 | |
| RTC6_YEAST | RTC6 | genetic | 27708008 | |
| YP260_YEAST | YPL260W | genetic | 27708008 | |
| MDL2_YEAST | MDL2 | genetic | 27708008 | |
| PHSG_YEAST | GPH1 | genetic | 27708008 | |
| UBR1_YEAST | UBR1 | genetic | 26466368 | |
| HSP71_YEAST | SSA1 | genetic | 26466368 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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