dbPTM

SNZ3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SNZ3_YEAST
UniProt AC	P43545
Protein Name	Probable pyridoxal 5'-phosphate synthase subunit SNZ3
Gene Name	SNZ3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	298
Subcellular Localization
Protein Description	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively..
Protein Sequence	MSEFKVKTGLAQMLKGGVIMDVVTPEQAIIAERAGACAVMALERIPADMRKSGQVCRMSDPRMIKEIMEAVSIPVMAKVRIGHFVEAQILEELQVDYIDESEVLTPADWTHHIEKHNFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKHITKIKAEIQQYKENLKTESDFAAKATELRVPVDLLKTTLSEGKLPVVNFAAGGVATPADAALLMQLGCEGVFVGSGIFKSSDPEKLACAIVEATTHYDNPAKLLQVSSDLGDLMGGISIQSINEAGGKNGARLSEIGW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Acetylation	VSIPVMAKVRIGHFV CCCCEEEEEECCCHH	17.60	24489116
127	Acetylation	VPFVCGAKDLGEALR CCEEECCCHHHHHHH	38.48	25381059
146	Ubiquitination	GAAMIRTKGEAGTGD CCCEEEECCCCCCCC	44.92	23749301
294	Phosphorylation	GKNGARLSEIGW--- CCCCCCHHHCCC---	22.93	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SNZ3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SNZ3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SNZ3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNO1_YEAST	SNO1	physical	11283351
SNZ2_YEAST	SNZ2	physical	11283351
SNO2_YEAST	SNO2	physical	11283351
SNZ3_YEAST	SNZ3	physical	11967834
SNZ1_YEAST	SNZ1	genetic	12271461
SNZ2_YEAST	SNZ2	genetic	12271461

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SNZ3_YEAST

Related Literatures of Post-Translational Modification