OTU1_YEAST - dbPTM
OTU1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OTU1_YEAST
UniProt AC P43558
Protein Name Ubiquitin thioesterase OTU1
Gene Name OTU1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 301
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Participates in the regulation of the ubiquin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May be indirectly involved in PIS1 gene expression..
Protein Sequence MKLKVTGAGINQVVTLKQDATLNDLIEHINVDVKTMRFGYPPQRINLQGEDASLGQTQLDELGINSGEKITIESSDSNESFSLPPPQPKPKRVLKSTEMSIGGSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVRDLREMVSKEVLNNPVKFNDAILDKPNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNEDKFDNYILILFNGIHYDSLTMNEFKTVFNKNQPESDDVLTAALQLASNLKQTGYSFNTHKAQIKCNTCQMTFVGEREVARHAESTGHVDFGQNR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34UbiquitinationEHINVDVKTMRFGYP
HHCCEEHHHCCCCCC		31.9424961812
71PhosphorylationINSGEKITIESSDSN
CCCCCCEEEECCCCC		29.7530377154
80PhosphorylationESSDSNESFSLPPPQ
ECCCCCCCCCCCCCC		25.1230377154
134PhosphorylationYGIFKQDSVRDLREM
HCHHCCCCHHHHHHH		19.2928889911
160UbiquitinationFNDAILDKPNKDYAQ
CCHHHHCCCCCCHHH		47.2322106047
262PhosphorylationNLKQTGYSFNTHKAQ
HHHHHCCCCCCCCCE		17.2330377154
267UbiquitinationGYSFNTHKAQIKCNT
CCCCCCCCCEEEECC		39.6923749301
271UbiquitinationNTHKAQIKCNTCQMT
CCCCCEEEECCCCEE		14.8922817900
291PhosphorylationEVARHAESTGHVDFG
HHHHHHHHCCCCCCC		40.2430377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OTU1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OTU1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OTU1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC48_YEASTCDC48physical
16554755
CDC48_YEASTCDC48physical
16427015
UFD1_YEASTUFD1physical
16427015
NPL4_YEASTNPL4physical
16427015
DOA1_YEASTDOA1physical
16427015
UBX1_YEASTSHP1physical
16427015
UFD2_YEASTUFD2physical
16427015
UBX1_YEASTSHP1physical
18719252
CDC48_YEASTCDC48physical
18719252
HSP71_YEASTSSA1physical
19536198
PHO23_YEASTPHO23genetic
20959818
UBI4P_YEASTUBI4physical
18270205
CDC48_YEASTCDC48physical
18270205
SECU_YEASTPDS1physical
22072716
BMH2_YEASTBMH2physical
22902402
CDC48_YEASTCDC48physical
22902402
COFI_YEASTCOF1physical
22902402
SYNC_YEASTDED81physical
22902402
FAS1_YEASTFAS1physical
22902402
DHE4_YEASTGDH1physical
22902402
H4_YEASTHHF1physical
22902402
DHOM_YEASTHOM6physical
22902402
HSC82_YEASTHSC82physical
22902402
ILV5_YEASTILV5physical
22902402
HOSM_YEASTLYS21physical
22902402
MPCP_YEASTMIR1physical
22902402
FBRL_YEASTNOP1physical
22902402
OTU1_YEASTOTU1physical
22902402
ODPB_YEASTPDB1physical
22902402
ADT2_YEASTPET9physical
22902402
PFKA1_YEASTPFK1physical
22902402
VDAC1_YEASTPOR1physical
22902402
RL13A_YEASTRPL13Aphysical
22902402
RL15A_YEASTRPL15Aphysical
22902402
RL16A_YEASTRPL16Aphysical
22902402
RL16B_YEASTRPL16Bphysical
22902402
RL17B_YEASTRPL17Bphysical
22902402
RL1A_YEASTRPL1Bphysical
22902402
RL1B_YEASTRPL1Bphysical
22902402
RL26A_YEASTRPL26Aphysical
22902402
RL3_YEASTRPL3physical
22902402
RL31A_YEASTRPL31Aphysical
22902402
RL33A_YEASTRPL33Aphysical
22902402
RL33B_YEASTRPL33Bphysical
22902402
RSSA1_YEASTRPS0Aphysical
22902402
RS15_YEASTRPS15physical
22902402
RS2_YEASTRPS2physical
22902402
RS31_YEASTRPS31physical
22902402
RS4A_YEASTRPS4Aphysical
22902402
RS4B_YEASTRPS4Aphysical
22902402
RS8A_YEASTRPS8Aphysical
22902402
RS8B_YEASTRPS8Aphysical
22902402
RS9B_YEASTRPS9Bphysical
22902402
SAHH_YEASTSAH1physical
22902402
METK1_YEASTSAM1physical
22902402
PMM_YEASTSEC53physical
22902402
SYSC_YEASTSES1physical
22902402
NOP56_YEASTNOP56physical
22902402
HSP71_YEASTSSA1physical
22902402
HSP72_YEASTSSA2physical
22902402
SSB1_YEASTSSB1physical
22902402
SSB2_YEASTSSB2physical
22902402
TKT1_YEASTTKL1physical
22902402
TCTP_YEASTTMA19physical
22902402
TSA1_YEASTTSA1physical
22902402
TSA2_YEASTTSA2physical
22902402
EF3A_YEASTYEF3physical
22902402
TERA_HUMANVCPphysical
24610782
UBI4P_YEASTUBI4physical
16427015
UBI4P_YEASTUBI4physical
23827681
ATE1_YEASTATE1genetic
27708008
XRN1_YEASTXRN1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
YG37_YEASTYGR127Wgenetic
27708008
SCW4_YEASTSCW4genetic
27708008
WSS1_YEASTWSS1genetic
27708008
SGN1_YEASTSGN1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
YJ24_YEASTKCH1genetic
27708008
FABG_YEASTOAR1genetic
27708008
DOA1_YEASTDOA1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
ACE2_YEASTACE2genetic
27708008
RSF1_YEASTRSF1genetic
27708008
SGS1_YEASTSGS1genetic
27708008
YHM2_YEASTYHM2genetic
27708008
FAR11_YEASTFAR11genetic
27708008
DSF1_YEASTYNR073Cgenetic
27708008
YN073_YEASTYNR073Cgenetic
27708008
HMI1_YEASTHMI1genetic
27708008
INO4_YEASTINO4genetic
27708008
DIA2_YEASTDIA2genetic
27708008
VAM3_YEASTVAM3genetic
27708008
HRD1_YEASTHRD1physical
25215493
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OTU1_YEAST

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Related Literatures of Post-Translational Modification

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