CPYI_YEAST - dbPTM
CPYI_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CPYI_YEAST
UniProt AC P14306
Protein Name Carboxypeptidase Y inhibitor
Gene Name TFS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 219
Subcellular Localization Cytoplasm.
Protein Description Specific and potent inhibitor of carboxypeptidase Y..
Protein Sequence MNQAIDFAQASIDSYKKHGILEDVIHDTSFQPSGILAVEYSSSAPVAMGNTLPTEKARSKPQFQFTFNKQMQKSVPQANAYVPQDDDLFTLVMTDPDAPSKTDHKWSEFCHLVECDLKLLNEATHETSGATEFFASEFNTKGSNTLIEYMGPAPPKGSGPHRYVFLLYKQPKGVDSSKFSKIKDRPNWGYGTPATGVGKWAKENNLQLVASNFFYAETK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNQAIDFA
-------CCHHHHHH		8.2812473200
15PhosphorylationAQASIDSYKKHGILE
HHHHHHHHHHCCCHH		21.9528132839
16AcetylationQASIDSYKKHGILED
HHHHHHHHHCCCHHH		42.1025381059
41PhosphorylationGILAVEYSSSAPVAM
CEEEEEECCCCCCCC		12.3328889911
42PhosphorylationILAVEYSSSAPVAMG
EEEEEECCCCCCCCC		29.6228889911
43PhosphorylationLAVEYSSSAPVAMGN
EEEEECCCCCCCCCC		30.5628889911
124PhosphorylationLKLLNEATHETSGAT
HHHHHHHHCCCCCCH		17.6722369663
127PhosphorylationLNEATHETSGATEFF
HHHHHCCCCCCHHHH		25.5122369663
128PhosphorylationNEATHETSGATEFFA
HHHHCCCCCCHHHHH		24.3622369663
131PhosphorylationTHETSGATEFFASEF
HCCCCCCHHHHHHHH		36.5322369663
136PhosphorylationGATEFFASEFNTKGS
CCHHHHHHHHCCCCC		37.2522369663
140PhosphorylationFFASEFNTKGSNTLI
HHHHHHCCCCCCCEE		41.9422369663
169AcetylationRYVFLLYKQPKGVDS
EEEEEEEECCCCCCH		61.1624489116
192PhosphorylationRPNWGYGTPATGVGK
CCCCCCCCCCCCCHH		10.9822369663
195PhosphorylationWGYGTPATGVGKWAK
CCCCCCCCCCHHHHH		33.3422369663
199AcetylationTPATGVGKWAKENNL
CCCCCCHHHHHHCCE		41.3924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CPYI_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CPYI_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CPYI_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IRA2_YEASTIRA2physical
15075275
PT111_YEASTPET111physical
16554755
IDHH_YEASTIDP3physical
16554755
CBPY_YEASTPRC1physical
9521655
IRA2_YEASTIRA2physical
17945254
EIF3A_YEASTRPG1physical
22515269
AP1_YEASTYAP1physical
22515269
NRD1_YEASTNRD1physical
22515269
BFR1_YEASTBFR1physical
22515269
PPID_YEASTCPR6physical
22515269
AMPL_YEASTAPE1physical
22515269
GLO3_YEASTGLO3physical
22515269
RIO2_YEASTRIO2physical
22515269
KES1_YEASTKES1physical
22515269
DLDH_YEASTLPD1physical
22515269
CISY1_YEASTCIT1physical
22515269
IDHP_YEASTIDP1physical
22515269
C1TC_YEASTADE3physical
22515269
PROB_YEASTPRO1physical
22515269
CSN12_YEASTYJR084Wgenetic
27708008
CWH43_YEASTCWH43genetic
27708008
PDP2_YEASTPTC6genetic
27708008
FIG2_YEASTFIG2genetic
27708008
ARF2_YEASTARF2genetic
27708008
ACK1_YEASTACK1genetic
27708008
HBT1_YEASTHBT1genetic
27708008
SXM1_YEASTSXM1genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
SDC1_YEASTSDC1genetic
27708008
IES1_YEASTIES1genetic
27708008
KSP1_YEASTKSP1genetic
27708008
HS150_YEASTHSP150genetic
27708008
RT109_YEASTRTT109genetic
27708008
HDA1_YEASTHDA1genetic
27708008
TCB2_YEASTTCB2genetic
27708008
PFA4_YEASTPFA4genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
CG12_YEASTCLN2genetic
27708008
HDA3_YEASTHDA3genetic
27708008
ATC2_YEASTPMC1genetic
27453043
DCOR_YEASTSPE1genetic
27453043
SYMC_YEASTMES1genetic
27453043
DCAM_YEASTSPE2genetic
27453043
ATG1_YEASTATG1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CPYI_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Overexpression and functional characterization of a serinecarboxypeptidase inhibitor (I(C)) from Saccharomyces cerevisiae.";
Mima J., Suzuki H., Takahashi M., Hayashi R.;
J. Biochem. 132:967-973(2002).
Cited for: CHARACTERIZATION, AND ACETYLATION AT MET-1.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-42 AND SER-43,AND MASS SPECTROMETRY.

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