dbPTM

NAA40_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NAA40_YEAST
UniProt AC	Q04751
Protein Name	N-alpha-acetyltransferase 40 {ECO:0000250\|UniProtKB:Q86UY6}
Gene Name	NAT4 {ECO:0000312\|SGD:S000004673}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	285
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A..
Protein Sequence	MRSSVYSENTYNCIRTSKEHLTERRRVAMAPMFQHFLNLCVEKFPESIEHKDTDGNGNFTTAILEREIIYIPEDDTDSIDSVDSLKCINYKLHKSRGDQVLDACVQLIDKHLGAKYRRASRIMYGNRKPWKANKLAEMKSAGLVYVCYWDNGVLGAFTSFMLTEETGLVEGDALHEVSVPVIYLYEVHVASAHRGHGIGRRLLEHALCDGVARHTRRMCDNFFGVALTVFSDNTRARRLYEALGFYRAPGSPAPASPTIRHTRHGGGRVVVPCDPLYYVYCLHMP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
84	Phosphorylation	DSIDSVDSLKCINYK CCCCCHHHHHHHHHE	27214570
115	Acetylation	IDKHLGAKYRRASRI HHHHHCHHHHHHHHH	25381059
251	Phosphorylation	GFYRAPGSPAPASPT CCCCCCCCCCCCCCC	21126336
256	Phosphorylation	PGSPAPASPTIRHTR CCCCCCCCCCCCEEC	25752575
258	Phosphorylation	SPAPASPTIRHTRHG CCCCCCCCCCEECCC	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NAA40_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NAA40_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NAA40_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H4_YEAST	HHF1	physical	12915400
RL3_YEAST	RPL3	physical	19332560
RS3_YEAST	RPS3	physical	19332560
G6PD_YEAST	ZWF1	physical	19332560
CACM_YEAST	YAT1	genetic	20093466
ECM33_YEAST	ECM33	genetic	20093466
NHP6B_YEAST	NHP6B	genetic	20093466
SND1_YEAST	YDR186C	genetic	20093466
SSD1_YEAST	SSD1	genetic	20093466
DBF2_YEAST	DBF2	genetic	20093466
YG2W_YEAST	YGR111W	genetic	20093466
UBR1_YEAST	UBR1	genetic	20093466
ETFB_YEAST	CIR1	genetic	20093466
SERB_YEAST	SER2	genetic	20093466
BNS1_YEAST	BNS1	genetic	20093466
SNF6_YEAST	SNF6	genetic	20093466
QCR10_YEAST	QCR10	genetic	20093466
VPS29_YEAST	VPS29	genetic	20093466
YHI9_YEAST	YHI9	genetic	20093466
PIH1_YEAST	PIH1	genetic	20093466
RPN10_YEAST	RPN10	genetic	20093466
SYG1_YEAST	SYG1	genetic	20093466
PIG2_YEAST	PIG2	genetic	20093466
PDK1_YEAST	PKP1	genetic	20093466
SNL1_YEAST	SNL1	genetic	20093466
GSH1_YEAST	GSH1	genetic	20093466
DHOM_YEAST	HOM6	genetic	20093466
FRMSR_YEAST	YKL069W	genetic	20093466
VPS13_YEAST	VPS13	genetic	20093466
MMM1_YEAST	MMM1	genetic	20093466
CDC73_YEAST	CDC73	genetic	20093466
GTR1_YEAST	GTR1	genetic	20093466
ERG2_YEAST	ERG2	genetic	20093466
HMI1_YEAST	HMI1	genetic	20093466
MDM12_YEAST	MDM12	genetic	20093466
DGK1_YEAST	DGK1	genetic	20093466
CHMU_YEAST	ARO7	genetic	20093466
VMA21_YEAST	VMA21	genetic	27708008
VRP1_YEAST	VRP1	genetic	27708008
MAK5_YEAST	MAK5	genetic	27708008
POP7_YEAST	POP7	genetic	27708008
RPB1_YEAST	RPO21	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
FDFT_YEAST	ERG9	genetic	27708008
HSP77_YEAST	SSC1	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
NEP1_YEAST	EMG1	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
SMC5_YEAST	SMC5	genetic	27708008
HRP1_YEAST	HRP1	genetic	27708008
SGT1_YEAST	SGT1	genetic	27708008
RS8A_YEAST	RPS8A	genetic	27708008
RS8B_YEAST	RPS8A	genetic	27708008
PFF1_YEAST	PFF1	genetic	27708008
ECM8_YEAST	ECM8	genetic	27708008
RER1_YEAST	RER1	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
PDP2_YEAST	PTC6	genetic	27708008
YD012_YEAST	YDL012C	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
YD129_YEAST	YDL129W	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
SNF1_YEAST	SNF1	genetic	27708008
TBP7_YEAST	YTA7	genetic	27708008
YIF4_YEAST	YIL054W	genetic	27708008
ICE2_YEAST	ICE2	genetic	27708008
ASF1_YEAST	ASF1	genetic	27708008
YPT6_YEAST	YPT6	genetic	27708008
ATG39_YEAST	YLR312C	genetic	27708008
MSC1_YEAST	MSC1	genetic	27708008
PUB1_YEAST	PUB1	genetic	27708008
RNH2A_YEAST	RNH201	genetic	27708008
TPM1_YEAST	TPM1	genetic	27708008
COQ2_YEAST	COQ2	genetic	27708008
LAG2_YEAST	LAG2	genetic	27708008
ROD1_YEAST	ROD1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
KIP2_YEAST	KIP2	genetic	27708008
AXL1_YEAST	AXL1	genetic	27708008
MMS1_YEAST	MMS1	genetic	27708008
H4_YEAST	HHF1	genetic	27799288
PNC1_YEAST	PNC1	genetic	27799288
MSN2_YEAST	MSN2	genetic	27799288
MSN4_YEAST	MSN4	genetic	27799288
SIR2_YEAST	SIR2	genetic	27799288

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NAA40_YEAST

Related Literatures of Post-Translational Modification