ETFB_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETFB_YEAST
• UniProt AC: P42940
• Protein Name: Probable electron transfer flavoprotein subunit beta
• Gene Name: CIR1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 261
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity)..
• Protein Sequence: MSAKQQLRILVPVKRVVDFQIKPRVNKTLTGIETSGIKFSINPFDDIAVEEAIRIKEKNKSLVESTHAVSIGSAKAQDILRNCLAKGIDTCSLIDSVGKENIEPLAIAKILKAVVEKKGSNLVLMGKQAIDDDCNNTGQMLAGLLNWPQATNAAKVEFLDNGRVQVTREIDDGEEVIEASLPMVITTDLRLNTPRYVGLPKLMKAKKKPIEKLDIAKDFPEINIEPQLKIVSMEEPKTKSPGVKLNSVDELIEKLKEVKAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAKQQLRI ------CCHHHHEEE	44.14	22814378
22	Acetylation	RVVDFQIKPRVNKTL EEECEEEECCCCCEE	18.91	24489116
30	Phosphorylation	PRVNKTLTGIETSGI CCCCCEECCEEECCE	41.15	28889911
34	Phosphorylation	KTLTGIETSGIKFSI CEECCEEECCEEEEE	30.27	27017623
61	Phosphorylation	RIKEKNKSLVESTHA HHHHHCHHHHEECCE	47.22	22369663
65	Phosphorylation	KNKSLVESTHAVSIG HCHHHHEECCEEECC	20.29	22369663
66	Phosphorylation	NKSLVESTHAVSIGS CHHHHEECCEEECCC	10.59	22369663
70	Phosphorylation	VESTHAVSIGSAKAQ HEECCEEECCCHHHH	23.24	22369663
73	Phosphorylation	THAVSIGSAKAQDIL CCEEECCCHHHHHHH	25.56	22369663
75	Acetylation	AVSIGSAKAQDILRN EEECCCHHHHHHHHH	48.56	24489116
109	Acetylation	IEPLAIAKILKAVVE CCHHHHHHHHHHHHH	42.32	24489116
120	Phosphorylation	AVVEKKGSNLVLMGK HHHHHCCCCEEEEEC	35.55	22369663
201	Acetylation	PRYVGLPKLMKAKKK CCCCCHHHHHHCCCC	67.28	24489116
217	Acetylation	IEKLDIAKDFPEINI HHHCCCCCCCCCCCC	61.30	24489116
254	Acetylation	SVDELIEKLKEVKAI CHHHHHHHHHHHHCC	58.84	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ETFB_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETFB_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETFB_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRDA_YEAST	YFH1	physical	15961414
RRP1_YEAST	RRP1	physical	16554755
LEUC_YEAST	LEU1	physical	16554755
SYEC_YEAST	GUS1	physical	16554755
YIK8_YEAST	YIL108W	physical	16554755
NEJ1_YEAST	NEJ1	physical	16554755
BIOA_YEAST	BIO3	physical	16554755
ROD1_YEAST	ROD1	physical	16554755
BMS1_YEAST	BMS1	physical	16554755
ALK2_YEAST	ALK2	genetic	27708008
TPS1_YEAST	TPS1	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
AIM4_YEAST	AIM4	genetic	27708008
YD012_YEAST	YDL012C	genetic	27708008
SHC1_YEAST	SHC1	genetic	27708008
LSB3_YEAST	LSB3	genetic	27708008
ATG1_YEAST	ATG1	genetic	27708008
DBF2_YEAST	DBF2	genetic	27708008
SDS3_YEAST	SDS3	genetic	27708008
RPA34_YEAST	RPA34	genetic	27708008
YJQ3_YEAST	YJL163C	genetic	27708008
ALAM_YEAST	ALT1	genetic	27708008
YL149_YEAST	YLR149C	genetic	27708008
PHO84_YEAST	PHO84	genetic	27708008
YMS4_YEAST	YMR034C	genetic	27708008
MPC54_YEAST	MPC54	genetic	27708008
MDM36_YEAST	MDM36	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.