HUL4_YEAST - dbPTM
HUL4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HUL4_YEAST
UniProt AC P40985
Protein Name Probable E3 ubiquitin-protein ligase HUL4
Gene Name HUL4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 892
Subcellular Localization Nucleus .
Protein Description Probable E3 ubiquitin-protein ligase, component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates..
Protein Sequence MVSLFDKLNAKKDGRDGSVSKELLSHSVAHTKNRLPKSGRRTSERSLAASVKDGSCSNSKSNKRNSSASVSGEEDKSCLISLNCLCCGVPLRFPASITKFRCSACQVTVIVKEPEINSNLESSTHISCTLEGLQMVVRRCHDDLQRLKKTGILDKERKGLIFQPVITYLLDRFHDVSILNRSFLVHDGGKNIKMLNYEVLQRFYSILSNLPTRKPYYSMLCCCNDLLKRITINKGENLQILQYRWLLIILNIPTIRTCLIRDRKSKNVFETQQIRAVSYELAKRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVEILNLYINFQFSRLLSNELSNRTAKNNVKPEDEMRSRLRRHHTTGHEFLSTRPISAQSNDKQGSGFTHPVNNKMKFKFFQYEEDWHIHSAAKLTFIYYVANTRRNGRGALSIQSFYNITLDFIDYKQDFDHWRGVAQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIKISIMEYEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEHQGDLLKSLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQLELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFEDVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQYNKFVSGFKRVFAECNSIKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCWFWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEICLWNYSSKKKLELKLLWAINESEGYGFR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationGRRTSERSLAASVKD
CCCCCHHHHHHHHCC		20.5024909858
50PhosphorylationSERSLAASVKDGSCS
CHHHHHHHHCCCCCC		24.8824909858
118PhosphorylationVKEPEINSNLESSTH
EECCCCCCCCCCCCE		48.7527017623
360PhosphorylationRLRRHHTTGHEFLST
HHHHHHCCCCHHHCC		31.9828889911
366PhosphorylationTTGHEFLSTRPISAQ
CCCCHHHCCCCCCCC		27.9128889911
371PhosphorylationFLSTRPISAQSNDKQ
HHCCCCCCCCCCCCC		23.9628889911
374PhosphorylationTRPISAQSNDKQGSG
CCCCCCCCCCCCCCC		46.8728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HUL4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HUL4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HUL4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MCK1_YEASTMCK1physical
16554755
LTE1_YEASTLTE1genetic
20093466
MAP2_YEASTMAP2genetic
20093466
PP2C3_YEASTPTC3genetic
20093466
ETR1_YEASTETR1genetic
20093466
YCA2_YEASTYCL002Cgenetic
20093466
ADP1_YEASTADP1genetic
20093466
LDB17_YEASTLDB17genetic
20093466
PBP4_YEASTPBP4genetic
20093466
TMS1_YEASTTMS1genetic
20093466
FIN1_YEASTFIN1genetic
20093466
HMO1_YEASTHMO1genetic
20093466
SSD1_YEASTSSD1genetic
20093466
CHI2_YEASTCTS2genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
SCS7_YEASTSCS7genetic
20093466
NST1_YEASTNST1genetic
20093466
ATP23_YEASTATP23genetic
20093466
PRPD_YEASTPDH1genetic
20093466
CHI2_YEASTCTS2genetic
27708008
PRX1_YEASTPRX1genetic
27708008
MAP2_YEASTMAP2genetic
27708008
ETR1_YEASTETR1genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
PP2C1_YEASTPTC1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
TMS1_YEASTTMS1genetic
27708008
RM01_YEASTMRPL1genetic
27708008
FIN1_YEASTFIN1genetic
27708008
RTR1_YEASTRTR1genetic
27708008
ODPA_YEASTPDA1genetic
27708008
SERB_YEASTSER2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
CHS7_YEASTCHS7genetic
27708008
KHA1_YEASTKHA1genetic
27708008
ASF1_YEASTASF1genetic
27708008
SCS7_YEASTSCS7genetic
27708008
NST1_YEASTNST1genetic
27708008
ATP23_YEASTATP23genetic
27708008
SGF11_YEASTSGF11genetic
27708008
PET20_YEASTPET20genetic
27708008
BEM4_YEASTBEM4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HUL4_YEAST

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Related Literatures of Post-Translational Modification

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