IST1_YEAST - dbPTM
IST1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IST1_YEAST
UniProt AC P53843
Protein Name Vacuolar protein sorting-associated protein IST1
Gene Name IST1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 298
Subcellular Localization Cytoplasm. Endosome. The endosomal location appears to be dependent on DID2.
Protein Description Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex..
Protein Sequence MAPSMIPFTIKLKTCLKMCIQRLRYAQEKQQAIAKQSRRQVAQLLLTNKEQKAHYRVETLIHDDIHIELLEILELYCELLLARVQVINDISTEEQLVKEHMDDGINEAIRSLIYAILFVDEVKELSQLKDLMAWKINVEFVNGVIADHIDVPEKIIKKCSPSVPKEELVDLYLKEIAKTYDVPYSKLENSLSSSSSNISSDFSDPSGDIEDNDEEKPILALDNDDNDNADAKHPITVKKPRQNSENIKNELKIPKDIKKEVIEKKQSEKKTTKRKTKKEQENDELDELKKRFDALRRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAPSMIPFTIK
----CCCCCCCCCCH		21.5830377154
9PhosphorylationAPSMIPFTIKLKTCL
CCCCCCCCCHHHHHH		16.3130377154
14PhosphorylationPFTIKLKTCLKMCIQ
CCCCHHHHHHHHHHH		33.2430377154
25PhosphorylationMCIQRLRYAQEKQQA
HHHHHHHHHHHHHHH		19.7528889911
192PhosphorylationSKLENSLSSSSSNIS
HHHHHHHCCCCCCCC		28.1721551504
193PhosphorylationKLENSLSSSSSNISS
HHHHHHCCCCCCCCC		39.2624961812
194PhosphorylationLENSLSSSSSNISSD
HHHHHCCCCCCCCCC		34.1224961812
195PhosphorylationENSLSSSSSNISSDF
HHHHCCCCCCCCCCC		29.3824961812
196PhosphorylationNSLSSSSSNISSDFS
HHHCCCCCCCCCCCC		39.8824961812
200PhosphorylationSSSSNISSDFSDPSG
CCCCCCCCCCCCCCC		38.5921551504
203PhosphorylationSNISSDFSDPSGDIE
CCCCCCCCCCCCCCC		54.3121551504
236PhosphorylationADAKHPITVKKPRQN
CCCCCCCEECCCCCC		30.6221440633
244PhosphorylationVKKPRQNSENIKNEL
ECCCCCCCHHHHHHC		24.5522369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IST1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IST1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IST1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EI2BG_YEASTGCD1physical
11805826
EI2BD_YEASTGCD2physical
11805826
EI2BE_YEASTGCD6physical
11805826
EI2BB_YEASTGCD7physical
11805826
EI2BA_YEASTGCN3physical
11805826
PROB_YEASTPRO1physical
11805826
RRP40_YEASTRRP40physical
11805826
RRP46_YEASTRRP46physical
11805826
IF2B_YEASTSUI3physical
11805826
XKS1_YEASTXKS1physical
11805826
COG8_YEASTCOG8physical
11805826
VPS4_YEASTVPS4physical
18032584
VPS27_YEASTVPS27physical
18032584
SNF7_YEASTSNF7physical
18032584
VTA1_YEASTVTA1genetic
18032584
VPS60_YEASTVPS60genetic
18032584
DID2_YEASTDID2physical
18032584
IST1_YEASTIST1physical
18467557
VPS4_YEASTVPS4physical
18032582
VPS4_YEASTVPS4genetic
18032582
VTA1_YEASTVTA1genetic
18032582
VTA1_YEASTVTA1genetic
20089837
VPS60_YEASTVPS60genetic
20089837
DID2_YEASTDID2physical
19477918
VTA1_YEASTVTA1genetic
19477918
YJE9_YEASTYJL049Wphysical
26510789
VTA1_YEASTVTA1genetic
26515066
MOB2_YEASTMOB2genetic
27708008
UAP1_YEASTQRI1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
ORC6_YEASTORC6genetic
27708008
PAN1_YEASTPAN1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
ERB1_YEASTERB1genetic
27708008
UTP15_YEASTUTP15genetic
27708008
CAP_YEASTSRV2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
CH10_YEASTHSP10genetic
27708008
MED10_YEASTNUT2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RS16A_YEASTRPS16Bgenetic
27708008
RS16B_YEASTRPS16Bgenetic
27708008
VPS60_YEASTVPS60genetic
27708008
ATG1_YEASTATG1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
EMC5_YEASTEMC5genetic
27708008
TED1_YEASTTED1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
RIC1_YEASTRIC1genetic
27708008
VTA1_YEASTVTA1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
BUD21_YEASTBUD21genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
COX10_YEASTCOX10genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IST1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.

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