| UniProt ID | GLRX4_YEAST | |
|---|---|---|
| UniProt AC | P32642 | |
| Protein Name | Monothiol glutaredoxin-4 | |
| Gene Name | GRX4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 244 | |
| Subcellular Localization | ||
| Protein Description | Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable).. | |
| Protein Sequence | MTVVEIKSQDQFTQLTTTNAANKLIVLYFKAQWADPCKTMSQVLEAVSEKVRQEDVRFLSIDADEHPEISDLFEIAAVPYFVFIQNGTIVKEISAADPKEFVKSLEILSNASASLANNAKGPKSTSDEESSGSSDDEEDETEEEINARLVKLVQAAPVMLFMKGSPSEPKCGFSRQLVGILREHQIRFGFFDILRDENVRQSLKKFSDWPTFPQLYINGEFQGGLDIIKESIEEDPEYFQHALQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | ADPCKTMSQVLEAVS CCCCCCHHHHHHHHH | 23.51 | 28889911 | |
| 99 | Acetylation | EISAADPKEFVKSLE EEECCCHHHHHHHHH | 65.42 | 24489116 | |
| 120 | Ubiquitination | ASLANNAKGPKSTSD HHHHHCCCCCCCCCC | 77.27 | 24961812 | |
| 124 | Phosphorylation | NNAKGPKSTSDEESS HCCCCCCCCCCCCCC | 35.96 | 19795423 | |
| 125 | Phosphorylation | NAKGPKSTSDEESSG CCCCCCCCCCCCCCC | 46.45 | 19795423 | |
| 126 | Phosphorylation | AKGPKSTSDEESSGS CCCCCCCCCCCCCCC | 50.55 | 19795423 | |
| 130 | Phosphorylation | KSTSDEESSGSSDDE CCCCCCCCCCCCCCC | 37.64 | 19823750 | |
| 131 | Phosphorylation | STSDEESSGSSDDEE CCCCCCCCCCCCCCC | 46.07 | 19795423 | |
| 133 | Phosphorylation | SDEESSGSSDDEEDE CCCCCCCCCCCCCHH | 32.32 | 19795423 | |
| 134 | Phosphorylation | DEESSGSSDDEEDET CCCCCCCCCCCCHHC | 53.24 | 23749301 | |
| 163 | Acetylation | APVMLFMKGSPSEPK CCEEEEECCCCCCCC | 49.23 | 24489116 | |
| 165 | Phosphorylation | VMLFMKGSPSEPKCG EEEEECCCCCCCCCC | 21.53 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLRX4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLRX4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLRX4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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