| UniProt ID | TCD1_YEAST | |
|---|---|---|
| UniProt AC | P38756 | |
| Protein Name | tRNA threonylcarbamoyladenosine dehydratase 1 | |
| Gene Name | TCD1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 429 | |
| Subcellular Localization |
Mitochondrion outer membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.. | |
| Protein Sequence | MANNTWKLIATTALISVFSTQLAKSVWKEYKLSCAANKNKTVSRPRQYDDHLFREQLARNYAFLGEEGMRKIKEQYIVIVGAGEVGSWVCTMLIRSGCQKIMIIDPENISIDSLNTHCCAVLSDIGKPKVQCLKEHLSKIAPWSEIKARAKAWTKENSHDLIFADGESPTFIVDCLDNLESKVDLLEYAHHNKIDVISSMGVATKSDPTRVSINDISMTEFDPISRCVRRKLRKRGIATGISVVFSNEMLDPRRDDILSPIDCEHRAINAVRDEALRHLPELGTMPGIFGLSIATWILTKVSGYPMKENEVKNRLKFYDSILETFQKQMARLNENKERSSLLGLEEVGYIVEEMFRGKSPISGYSTKLALTKWEANKEISLTNVVLMTKEEQEIHEKRILLDGEKLTAVYSEEVLDFIERLFKEEEYYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Ubiquitination | -MANNTWKLIATTAL -CCCCHHHHHHHHHH | 17644757 | ||
| 24 | Ubiquitination | VFSTQLAKSVWKEYK HHHHHHHHHHHHHHH | 17644757 | ||
| 147 | Acetylation | IAPWSEIKARAKAWT HCCHHHHHHHHHHHC | 24489116 | ||
| 259 | Phosphorylation | PRRDDILSPIDCEHR CCCCCCCCCCCCCHH | 17330950 | ||
| 307 | Ubiquitination | KVSGYPMKENEVKNR HHCCCCCCHHHHHHH | 23749301 | ||
| 359 | Phosphorylation | EEMFRGKSPISGYST HHHHCCCCCCCCCHH | 26447709 | ||
| 362 | Phosphorylation | FRGKSPISGYSTKLA HCCCCCCCCCHHHHE | 26447709 | ||
| 364 | Phosphorylation | GKSPISGYSTKLALT CCCCCCCCHHHHEEH | 26447709 | ||
| 423 | Ubiquitination | DFIERLFKEEEYYS- HHHHHHHCHHHHCC- | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCD1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCD1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCD1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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