UIP4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UIP4_YEAST
• UniProt AC: Q08926
• Protein Name: ULP1-interacting protein 4
• Gene Name: UIP4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 304
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion outer membrane . Nucleus envelope .
• Protein Sequence: MVTIVFDHPAEDFPELKIAGEFTNWEGVPMKINTSSGKWEYKFDESSVTKHNDKDKVHFKFIDQNGNWFADDEYPKEVDEHSNENNVATLNNEEDGGSAGEEKDEGDKTAHNTNENGSELYYEGPETPTPSLKGNVTFPSPKTAISQDGSAFAKETTRKERKYEHAPLNEVPVERDPKEENKELSPNFSQEQTENKQDKGLDNLSEGNDNDNTRVNEDTDVTDTQESEHEINGSDTENTDMSEQEEIQKIDKPADQNAKSIVKEGDANTEDYESVLKKLLGALGRFFGSWFSWLTTKMSSSEAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	WEYKFDESSVTKHND EEEEECHHHCCCCCC	31.77	30377154
82	Phosphorylation	PKEVDEHSNENNVAT CCCCCCCCCCCCEEE	43.73	22369663
89	Phosphorylation	SNENNVATLNNEEDG CCCCCEEECCCCCCC	26.24	22369663
98	Phosphorylation	NNEEDGGSAGEEKDE CCCCCCCCCCCCCCC	38.33	22369663
109	Phosphorylation	EKDEGDKTAHNTNEN CCCCCCCCCCCCCCC	37.58	22369663
113	Phosphorylation	GDKTAHNTNENGSEL CCCCCCCCCCCCCEE	33.76	22369663
118	Phosphorylation	HNTNENGSELYYEGP CCCCCCCCEEEEECC	35.69	22369663
121	Phosphorylation	NENGSELYYEGPETP CCCCCEEEEECCCCC	8.74	22369663
122	Phosphorylation	ENGSELYYEGPETPT CCCCEEEEECCCCCC	27.34	22369663
127	Phosphorylation	LYYEGPETPTPSLKG EEEECCCCCCCCCCC	35.28	22369663
129	Phosphorylation	YEGPETPTPSLKGNV EECCCCCCCCCCCCE	32.69	22369663
131	Phosphorylation	GPETPTPSLKGNVTF CCCCCCCCCCCCEEC	45.23	22369663
137	Phosphorylation	PSLKGNVTFPSPKTA CCCCCCEECCCCCCE	33.55	22369663
140	Phosphorylation	KGNVTFPSPKTAISQ CCCEECCCCCCEECC	34.53	22369663
143	Phosphorylation	VTFPSPKTAISQDGS EECCCCCCEECCCCC	32.38	22369663
146	Phosphorylation	PSPKTAISQDGSAFA CCCCCEECCCCCHHH	21.54	22369663
150	Phosphorylation	TAISQDGSAFAKETT CEECCCCCHHHHHHH	28.62	29136822
185	Phosphorylation	KEENKELSPNFSQEQ HHHCCCCCCCCCHHH	20.91	22369663
189	Phosphorylation	KELSPNFSQEQTENK CCCCCCCCHHHHHCC	39.17	22369663
193	Phosphorylation	PNFSQEQTENKQDKG CCCCHHHHHCCCCCC	40.55	22369663
205	Phosphorylation	DKGLDNLSEGNDNDN CCCCCCCCCCCCCCC	50.11	22369663
213	Phosphorylation	EGNDNDNTRVNEDTD CCCCCCCCCCCCCCC	38.57	22369663
278	Acetylation	DYESVLKKLLGALGR HHHHHHHHHHHHHHH	44.79	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UIP4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UIP4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UIP4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWA2_YEAST	SWA2	genetic	21987634
GABAT_YEAST	UGA1	genetic	21987634

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-185 ANDSER-205, AND MASS SPECTROMETRY.
PubMed: 18407956

"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-185 ANDSER-205, AND MASS SPECTROMETRY.
PubMed: 17761666