SKG1_YEAST - dbPTM
SKG1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SKG1_YEAST
UniProt AC P36169
Protein Name Suppressor of lethality of KEX2 GAS1 double null mutant protein 1
Gene Name SKG1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 355
Subcellular Localization Cell membrane
Single-pass type III membrane protein
Cytoplasmic side. Bud membrane
Single-pass type III membrane protein
Cytoplasmic side. Localizes on the inner surface of the plasma membrane at the bud and in the daughter cell. Localizes at an
Protein Description Plays a role in cell wall integrity. Affects the cell wall polymer composition in the growing region of the cell..
Protein Sequence MTASTSVAVGCAVGIPVGVGIIIAVCFWFNLQKRYKREEQDDRELERAIYDESGFVSFDNFGPLRDSKDEAALASSELKNPDHTSGSSEGSAHPEEKDGKSRDQEKPLGKKNSKYYVPAYRRKINLLQVRNNNYGNNARQKSVVDLPSINNSSNVSLSSSQRHITKRQISVYDQMVPVISDEGPNFFADPSSDTNTSNDQNKASMIELKHNTRQSSNENLIRNLQNQDFGSYYPRRASSSFLNGNISNASFHTRNSSITSVNKRDALEDVFATPKSAAQSQLPNTFDKDNEGMDADHSVKDSRSAITDKDKDLYKLQNNYDVGNIGEIAEEDQYENEFTNYSQSKREFIESLRPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationRELERAIYDESGFVS
HHHHHHHHCCCCCEE		16.8122369663
53PhosphorylationERAIYDESGFVSFDN
HHHHHCCCCCEECCC		34.3328132839
57PhosphorylationYDESGFVSFDNFGPL
HCCCCCEECCCCCCC		25.3128132839
67PhosphorylationNFGPLRDSKDEAALA
CCCCCCCCHHHHHHH		35.2622369663
68UbiquitinationFGPLRDSKDEAALAS
CCCCCCCHHHHHHHH		64.9723749301
75PhosphorylationKDEAALASSELKNPD
HHHHHHHHHHHCCCC		25.7922890988
76PhosphorylationDEAALASSELKNPDH
HHHHHHHHHHCCCCC		41.1422890988
84PhosphorylationELKNPDHTSGSSEGS
HHCCCCCCCCCCCCC		42.0129136822
85PhosphorylationLKNPDHTSGSSEGSA
HCCCCCCCCCCCCCC		33.0029136822
87PhosphorylationNPDHTSGSSEGSAHP
CCCCCCCCCCCCCCC		25.6129136822
88PhosphorylationPDHTSGSSEGSAHPE
CCCCCCCCCCCCCCC		49.8829136822
91PhosphorylationTSGSSEGSAHPEEKD
CCCCCCCCCCCCCCC		21.2529136822
106UbiquitinationGKSRDQEKPLGKKNS
CCCCCCCCCCCCCCC		39.6523749301
142PhosphorylationGNNARQKSVVDLPSI
CCCCCCCEEECCCCC		21.0223749301
148PhosphorylationKSVVDLPSINNSSNV
CEEECCCCCCCCCCC		45.2923749301
152PhosphorylationDLPSINNSSNVSLSS
CCCCCCCCCCCCCCH		20.8520377248
153PhosphorylationLPSINNSSNVSLSSS
CCCCCCCCCCCCCHH		43.2920377248
156PhosphorylationINNSSNVSLSSSQRH
CCCCCCCCCCHHCCC		27.1220377248
158PhosphorylationNSSNVSLSSSQRHIT
CCCCCCCCHHCCCCC		22.0420377248
159PhosphorylationSSNVSLSSSQRHITK
CCCCCCCHHCCCCCH		35.4620377248
160PhosphorylationSNVSLSSSQRHITKR
CCCCCCHHCCCCCHH		28.0520377248
165PhosphorylationSSSQRHITKRQISVY
CHHCCCCCHHHEEEH		17.6620377248
180PhosphorylationDQMVPVISDEGPNFF
HHCCEEECCCCCCCC		29.8220377248
191PhosphorylationPNFFADPSSDTNTSN
CCCCCCCCCCCCCCC		41.2021440633
192PhosphorylationNFFADPSSDTNTSND
CCCCCCCCCCCCCCC		54.5721440633
196PhosphorylationDPSSDTNTSNDQNKA
CCCCCCCCCCCCHHH		30.8821440633
197PhosphorylationPSSDTNTSNDQNKAS
CCCCCCCCCCCHHHH		40.2420377248
204PhosphorylationSNDQNKASMIELKHN
CCCCHHHHHHHHHHH		23.1521551504
212PhosphorylationMIELKHNTRQSSNEN
HHHHHHHCCCCCCHH		29.7922369663
215PhosphorylationLKHNTRQSSNENLIR
HHHHCCCCCCHHHHH		31.6622369663
216PhosphorylationKHNTRQSSNENLIRN
HHHCCCCCCHHHHHH		39.5622369663
238PhosphorylationSYYPRRASSSFLNGN
HCCCCCCCCCCCCCC		25.3822369663
239PhosphorylationYYPRRASSSFLNGNI
CCCCCCCCCCCCCCC		24.9122369663
240PhosphorylationYPRRASSSFLNGNIS
CCCCCCCCCCCCCCC		31.1222369663
247PhosphorylationSFLNGNISNASFHTR
CCCCCCCCCCEEECC		30.2822369663
250PhosphorylationNGNISNASFHTRNSS
CCCCCCCEEECCCCC		23.0822369663
253PhosphorylationISNASFHTRNSSITS
CCCCEEECCCCCCCC		29.5422369663
256PhosphorylationASFHTRNSSITSVNK
CEEECCCCCCCCCCH		21.5922369663
257PhosphorylationSFHTRNSSITSVNKR
EEECCCCCCCCCCHH		33.1722369663
259PhosphorylationHTRNSSITSVNKRDA
ECCCCCCCCCCHHHH		28.6822369663
260PhosphorylationTRNSSITSVNKRDAL
CCCCCCCCCCHHHHH		23.2522369663
263UbiquitinationSSITSVNKRDALEDV
CCCCCCCHHHHHHHH		49.8823749301
273PhosphorylationALEDVFATPKSAAQS
HHHHHHCCHHHHHHH		21.5622369663
276PhosphorylationDVFATPKSAAQSQLP
HHHCCHHHHHHHCCC		30.0022369663
280PhosphorylationTPKSAAQSQLPNTFD
CHHHHHHHCCCCCCC		29.0222890988
285PhosphorylationAQSQLPNTFDKDNEG
HHHCCCCCCCCCCCC		31.1322890988
288UbiquitinationQLPNTFDKDNEGMDA
CCCCCCCCCCCCCCC		59.2623749301
298PhosphorylationEGMDADHSVKDSRSA
CCCCCCCCCCCCHHH		31.2622890988
302PhosphorylationADHSVKDSRSAITDK
CCCCCCCCHHHCCCC		23.5521551504
304PhosphorylationHSVKDSRSAITDKDK
CCCCCCHHHCCCCCH		28.1627717283
307PhosphorylationKDSRSAITDKDKDLY
CCCHHHCCCCCHHHH		36.3927717283
339PhosphorylationDQYENEFTNYSQSKR
HHHHCCCCCHHHHHH		27.3727017623
342PhosphorylationENEFTNYSQSKREFI
HCCCCCHHHHHHHHH		30.0127017623
344PhosphorylationEFTNYSQSKREFIES
CCCCHHHHHHHHHHH		27.9527017623
345UbiquitinationFTNYSQSKREFIESL
CCCHHHHHHHHHHHH		48.5923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SKG1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SKG1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SKG1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GET3_YEASTGET3physical
11283351
SAC7_YEASTSAC7genetic
23891562
ECM7_YEASTECM7genetic
23891562
VPS41_YEASTVPS41genetic
27708008
AIM18_YEASTAIM18genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
PMS1_YEASTPMS1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
PP2C3_YEASTPTC3genetic
27708008
TPS1_YEASTTPS1genetic
27708008
VBA3_YEASTVBA3genetic
27708008
BRE1_YEASTBRE1genetic
27708008
INO2_YEASTINO2genetic
27708008
SAS4_YEASTSAS4genetic
27708008
DOT1_YEASTDOT1genetic
27708008
ATC5_YEASTDNF1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
NAM8_YEASTNAM8genetic
27708008
KC11_YEASTYCK1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
BCK1_YEASTBCK1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
PUR91_YEASTADE16genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ELO3_YEASTELO3genetic
27708008
ECM7_YEASTECM7genetic
27708008
YM01_YEASTYMR111Cgenetic
27708008
SAS2_YEASTSAS2genetic
27708008
IPA3_YEASTPAI3genetic
27708008
RCM1_YEASTRCM1genetic
27708008
EFM6_YEASTYNL024Cgenetic
27708008
ELG1_YEASTELG1genetic
27708008
SAS5_YEASTSAS5genetic
27708008
KIN4_YEASTKIN4genetic
27708008
LGE1_YEASTLGE1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
CTF4_YEASTCTF4genetic
27708008
SUE1_YEASTSUE1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SKG1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238; SER-257; SER-260AND THR-273, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256; SER-257 ANDSER-260, AND MASS SPECTROMETRY.

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