FAR8_YEAST - dbPTM
FAR8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAR8_YEAST
UniProt AC Q05040
Protein Name Factor arrest protein 8
Gene Name FAR8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Cytoplasm . Endoplasmic reticulum .
Protein Description Participates in the control of the reentry into the cell cycle following pheromone treatment..
Protein Sequence MAINQAHVHPHYTLPGVMHYLQTEFTKNERDRITWELERSEMKARIAELEGENRDLKHQLNQIQSKAVSPEGEKEEKHVPDSLLQSKLAVQENVKEIIYLLKGPNTVNQLESLNSREAGSELHDLEKLNVNTPKEEGSAKTNGMDILNNALLDTKPNPKQGPSESPSPTKVKSLFSTANKRENNETISKIHSELSKVDIISSYGDCMALYDADTKSLEIHQVDANLNSKLLKKISLGQDSDIMKFFWVSTSKLLVIEKSFHLKLFSISSASLISDVDLLQDSEQPFSSSDIINIDFKNKWLLIASKNKSQIRIWELDNIEAPEDVPINIKETYEITHDNDDDDSNDSTNILDCILGITEKSLILLSSNPYQLTIYDFEGKLLQKIDLKIDTILSGKPEEEGYHLFLDRKTSKLLIQLSNERLLVYSFDKKKVVLKEQLTPSSTLPIQLDLNDSIITVSYSNGDFEFRNLENLKPSIDEFVVADINFSERKEPVVFSSNLIVDSTPVLITVNKNNEVLLHKIKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65PhosphorylationHQLNQIQSKAVSPEG
HHHHHHHHHCCCCCC		24.9830377154
69PhosphorylationQIQSKAVSPEGEKEE
HHHHHCCCCCCHHHH		23.3029136822
77AcetylationPEGEKEEKHVPDSLL
CCCHHHHHCCCHHHH		51.5024489116
112PhosphorylationNTVNQLESLNSREAG
CHHHHHHHCCCCCCC		41.2522369663
115PhosphorylationNQLESLNSREAGSEL
HHHHHCCCCCCCCCC		36.4722369663
120PhosphorylationLNSREAGSELHDLEK
CCCCCCCCCCHHHHH		43.9921440633
132PhosphorylationLEKLNVNTPKEEGSA
HHHCCCCCCCCCCCC		31.3022369663
138PhosphorylationNTPKEEGSAKTNGMD
CCCCCCCCCCCCCHH		29.8522369663
163PhosphorylationPNPKQGPSESPSPTK
CCCCCCCCCCCCCHH		58.4922369663
165PhosphorylationPKQGPSESPSPTKVK
CCCCCCCCCCCHHHH		34.7122369663
167PhosphorylationQGPSESPSPTKVKSL
CCCCCCCCCHHHHHH		55.2522369663
169PhosphorylationPSESPSPTKVKSLFS
CCCCCCCHHHHHHHH		53.4522369663
192PhosphorylationETISKIHSELSKVDI
HHHHHHHHHHHHCEE		43.6427017623
201PhosphorylationLSKVDIISSYGDCMA
HHHCEEEECCCCEEE		20.1727017623
214PhosphorylationMALYDADTKSLEIHQ
EEEEECCCCCEEEEE		25.0127017623
429AcetylationLLVYSFDKKKVVLKE
EEEEEECCCEEEEEE		53.1124489116
430AcetylationLVYSFDKKKVVLKEQ
EEEEECCCEEEEEEC		53.2824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAR8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAR8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAR8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IML2_YEASTIML2physical
16554755
IMDH2_YEASTIMD2physical
16429126
ACO1_YEASTOLE1genetic
16269340
CHO2_YEASTCHO2genetic
16269340
MGA2_YEASTMGA2genetic
16269340
UBX2_YEASTUBX2genetic
16269340
DGK1_YEASTDGK1genetic
16269340
SEC22_YEASTSEC22genetic
16269340
STV1_YEASTSTV1genetic
16269340
RGP1_YEASTRGP1genetic
16269340
SSO2_YEASTSSO2genetic
16269340
ERG4_YEASTERG4genetic
16269340
TMEDA_YEASTERV25genetic
16269340
PLMT_YEASTOPI3genetic
16269340
SHR3_YEASTSHR3genetic
16269340
RIC1_YEASTRIC1genetic
16269340
PGA3_YEASTPGA3genetic
16269340
MGA2_YEASTMGA2genetic
19325107
UBX2_YEASTUBX2genetic
19325107
VPS9_YEASTVPS9genetic
19325107
FAR11_YEASTFAR11physical
22298706
LHS1_YEASTLHS1physical
22875988
DID2_YEASTDID2physical
22875988
NST1_YEASTNST1physical
22875988
RLF2_YEASTRLF2physical
22875988
VPS64_YEASTVPS64physical
23625923
FAR10_YEASTFAR10physical
23625923
LST8_YEASTLST8genetic
27708008
SNF5_YEASTSNF5genetic
27708008
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
GLE1_YEASTGLE1genetic
27708008
GPI11_YEASTGPI11genetic
27708008
GPI19_YEASTGPI19genetic
27708008
MOB2_YEASTMOB2genetic
27708008
NUP57_YEASTNUP57genetic
27708008
RPN1_YEASTRPN1genetic
27708008
MED6_YEASTMED6genetic
27708008
ATC7_YEASTNEO1genetic
27708008
SED5_YEASTSED5genetic
27708008
NEP1_YEASTEMG1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RPN4_YEASTRPN4genetic
27708008
UBP5_YEASTUBP5genetic
27708008
VMA21_YEASTVMA21genetic
27708008
CHO2_YEASTCHO2genetic
27708008
OSH3_YEASTOSH3genetic
27708008
VPS53_YEASTVPS53genetic
27708008
SAC1_YEASTSAC1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAR8_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-115 AND SER-167,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163; SER-165 ANDSER-167, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-132, AND MASSSPECTROMETRY.

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