FKBP4_YEAST - dbPTM
FKBP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FKBP4_YEAST
UniProt AC Q06205
Protein Name FK506-binding protein 4 {ECO:0000305|PubMed:9371805}
Gene Name FPR4 {ECO:0000303|PubMed:9371805}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 392
Subcellular Localization Nucleus .
Protein Description PPIase that acts as a histone chaperone. [PubMed: 14981505]
Protein Sequence MSDMLPLATYSLNVEPYSPTPALNFKIPVTIRITMAAIDPEPFDDDKKPSTLRIIKRNPELTRGEYYNQDNNDGLEEDESESEQEADVPKRSVKSKKGKAVEQSESEDSEDENEIDDEFEECVLLTLSPKGQYQQALDITIAPEEDVQFVVTGSYTISLTGNYVKHPFDNSSDSDEDEEDYYSDEESSNGEEEEEEEEEDDEELSSGDDDLDDLVDASDIESRLDELVKKDEKKKNNKKDSKRKHEEDEEESAKPAEKKQTTKKDKKAEKVKDSEESKPKPKTKLLEGGIIIEDRVTGKGPHAKKGTRVGMRYVGKLKNGKVFDKNTKGKPFVFKLGQGEVIKGWDIGVAGMAVGGERRIVIPAPYAYGKQALPGIPANSELTFDVKLVSMK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationSDMLPLATYSLNVEP
CCCCCEEEEEECCCC		22.7130377154
18PhosphorylationSLNVEPYSPTPALNF
EECCCCCCCCCCCCC		32.7730377154
20PhosphorylationNVEPYSPTPALNFKI
CCCCCCCCCCCCCCC		18.4328889911
34PhosphorylationIPVTIRITMAAIDPE
CEEEEEEEEEECCCC		7.3028889911
47AcetylationPEPFDDDKKPSTLRI
CCCCCCCCCCCCEEH		73.8424489116
48AcetylationEPFDDDKKPSTLRII
CCCCCCCCCCCEEHH		51.7124489116
50PhosphorylationFDDDKKPSTLRIIKR
CCCCCCCCCEEHHHC		49.2919779198
62PhosphorylationIKRNPELTRGEYYNQ
HHCCCCCCCCCCCCC		34.6621440633
66PhosphorylationPELTRGEYYNQDNND
CCCCCCCCCCCCCCC		15.5622369663
67PhosphorylationELTRGEYYNQDNNDG
CCCCCCCCCCCCCCC		11.3122369663
80PhosphorylationDGLEEDESESEQEAD
CCCCCCCCHHHHHHC		59.7622369663
82PhosphorylationLEEDESESEQEADVP
CCCCCCHHHHHHCCC		54.5922369663
104PhosphorylationKGKAVEQSESEDSED
CCCCCCCCCCCCCCC		29.5921551504
106PhosphorylationKAVEQSESEDSEDEN
CCCCCCCCCCCCCCC		52.5321551504
109PhosphorylationEQSESEDSEDENEID
CCCCCCCCCCCCCCC		42.7821551504
218PhosphorylationLDDLVDASDIESRLD
HHHHCCHHHHHHHHH		34.3628889911
335AcetylationKGKPFVFKLGQGEVI
CCCCEEEEECCCCEE		46.5424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FKBP4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FKBP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FKBP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOG1_YEASTNOG1physical
16429126
PUF6_YEASTPUF6physical
16429126
RIX7_YEASTRIX7physical
16429126
RL3_YEASTRPL3physical
16429126
ARX1_YEASTARX1physical
16429126
ERB1_YEASTERB1physical
16429126
NOC3_YEASTNOC3physical
16429126
NOP2_YEASTNOP2physical
16429126
RL5_YEASTRPL5physical
16429126
RL7A_YEASTRPL7Aphysical
16429126
H3_YEASTHHT1physical
16959570
H4_YEASTHHF1physical
16959570
CSF1_YEASTCSF1genetic
17314980
NOC2_YEASTNOC2physical
18467557
TCM62_YEASTTCM62genetic
20093466
TPS1_YEASTTPS1genetic
20093466
YBY9_YEASTYBR139Wgenetic
20093466
ODPB_YEASTPDB1genetic
20093466
STE50_YEASTSTE50genetic
20093466
RL41A_YEASTRPL41Agenetic
20093466
RL41B_YEASTRPL41Agenetic
20093466
RV167_YEASTRVS167genetic
20093466
RS17B_YEASTRPS17Bgenetic
20093466
ISC10_YEASTISC10genetic
20093466
KIP3_YEASTKIP3genetic
20093466
CUE3_YEASTCUE3genetic
20093466
YGD9_YEASTYGL039Wgenetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
MTL1_YEASTMTL1genetic
20093466
PEF1_YEASTPEF1genetic
20093466
PLMT_YEASTOPI3genetic
20093466
KAPS_YEASTMET14genetic
20093466
SIC1_YEASTSIC1genetic
20093466
H3_YEASTHHT1physical
23888048
FKBP4_YEASTFPR4physical
25813344
EBP2_YEASTEBP2physical
25877921
LOC1_YEASTLOC1physical
25877921
SPB1_YEASTSPB1physical
25877921
NOP12_YEASTNOP12physical
25877921
NOP53_YEASTNOP53physical
25877921
TEL2_YEASTTEL2genetic
27708008
MED6_YEASTMED6genetic
27708008
NOP2_YEASTNOP2genetic
27708008
VPS10_YEASTPEP1genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
TCM62_YEASTTCM62genetic
27708008
TPS1_YEASTTPS1genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
NPL4_YEASTNPL4genetic
27708008
AGP1_YEASTAGP1genetic
27708008
STE50_YEASTSTE50genetic
27708008
RIM1_YEASTRIM1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
RS17B_YEASTRPS17Bgenetic
27708008
ISC10_YEASTISC10genetic
27708008
IES1_YEASTIES1genetic
27708008
YGD9_YEASTYGL039Wgenetic
27708008
SGF73_YEASTSGF73genetic
27708008
CUE3_YEASTCUE3genetic
27708008
CTU1_YEASTNCS6genetic
27708008
KIP3_YEASTKIP3genetic
27708008
ASK10_YEASTASK10genetic
27708008
TBP7_YEASTYTA7genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
FEN1_YEASTRAD27genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
SWS2_YEASTSWS2genetic
27708008
STI1_YEASTSTI1genetic
27708008
LCF1_YEASTFAA1genetic
27708008
LEE1_YEASTLEE1genetic
27708008
H31_HUMANHIST1H3Aphysical
28630422
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FKBP4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20; SER-80; SER-82 ANDSER-218, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-82, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-82, AND MASSSPECTROMETRY.
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae.";
Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.;
Nat. Biotechnol. 20:301-305(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-82, AND MASSSPECTROMETRY.

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