dbPTM

TOS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOS1_YEAST
UniProt AC	P38288
Protein Name	Protein TOS1
Gene Name	TOS1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	455
Subcellular Localization	Secreted .
Protein Description
Protein Sequence	MLQKLSMTALVGLFSSVVSLVNADCTYSGGNYYCAQTDAIIYSNVGLSATYQDVTNMDESSCACTQADFTASGSLAPFNEELSVHFRGPIELLQFGVYYPNGESNALKKRSEKQSIESCKEGEAVVSRHKHQHKRDVAVEYVQVTSTVYVDSNGQTVTADSTNTVVGPAVPSSYTKDSTVLSSSAQAVETSESQSSISSSKTTSSAAAASSSSSSSSNTNGDWSRGSYFVPGSTSNCTFMNNQGGTAGSGVWSSCFGNSISFAASDGVSGAASAQALGDVTIKSGNEFMIFSGEECSGNNGDCGYYREGIPAYHGFGGADKIFVFEFSMPSDTSGSAYNQDMPAIWLLNAKIPRTLQYGDASCSCWKTGCGEMDLFEILTAGSDKLISHIHDGQDGGTQDYFERPTDGTLKAAVIFNSSDKTIHIIEVDESFDATLSDDVVDQWLSKSGSSAALP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Ubiquitination	KQSIESCKEGEAVVS HHHHHHHHHCCHHHH	77.39	23749301
236	N-linked_Glycosylation	FVPGSTSNCTFMNNQ EECCCCCCCEEECCC	29.01	-
417	N-linked_Glycosylation	LKAAVIFNSSDKTIH EEEEEEECCCCCEEE	29.49	-
448	Phosphorylation	VDQWLSKSGSSAALP HHHHHHHCCCCCCCC	40.30	17563356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TOS1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TOS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THDH_YEAST	ILV1	physical	11805826
SCJ1_YEAST	SCJ1	physical	11805826
COPG_YEAST	SEC21	physical	11805826
COPB_YEAST	SEC26	physical	11805826
SLA1_YEAST	SLA1	genetic	23891562
ATC1_YEAST	PMR1	genetic	23891562
ERD1_YEAST	ERD1	genetic	23891562
MNN2_YEAST	MNN2	genetic	23891562
MNN11_YEAST	MNN11	genetic	23891562
HOC1_YEAST	HOC1	genetic	23891562
HAC1_YEAST	HAC1	genetic	23891562
VPS27_YEAST	VPS27	genetic	23891562
GDA1_YEAST	GDA1	genetic	23891562
GLO3_YEAST	GLO3	genetic	23891562
RUD3_YEAST	RUD3	genetic	23891562
VPS1_YEAST	VPS1	genetic	23891562
VPS5_YEAST	VPS5	genetic	23891562
CCW12_YEAST	CCW12	genetic	23891562
CSG2_YEAST	CSG2	genetic	23891562
TPM1_YEAST	TPM1	genetic	23891562
PSB5_YEAST	PRE2	genetic	23891562
KPC1_YEAST	PKC1	genetic	27708008
SWI5_YEAST	SWI5	genetic	27708008
NUM1_YEAST	NUM1	genetic	27708008
TCPZ_YEAST	CCT6	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
SLA1_YEAST	SLA1	genetic	27708008
RV161_YEAST	RVS161	genetic	27708008
ARO1_YEAST	ARO1	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
PMP3_YEAST	PMP3	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
ATC1_YEAST	PMR1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
MAL12_YEAST	MAL12	genetic	27708008
HOC1_YEAST	HOC1	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TOS1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, AND MASSSPECTROMETRY.	17563356 [Abstract]