GDE1_YEAST - dbPTM
GDE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GDE1_YEAST
UniProt AC Q02979
Protein Name Glycerophosphocholine phosphodiesterase GDE1 {ECO:0000303|PubMed:16141200}
Gene Name GDE1 {ECO:0000303|PubMed:16141200}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1223
Subcellular Localization Cytoplasm .
Protein Description Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. [PubMed: 16141200]
Protein Sequence MKFGKTFANHRIPEWSSQYVGYKSLKKMIKEITRLQEDIYRAHNKNSYDEGRPPTKMRDSSNSAQNYLDSPKIQKLLASFFFAVDRDIEKVDTFYNSQYAEYKKRFERLLSSNQFNEIKSTLVVDANKEDAVAQTLLTKDTREMNMLLKGTSQASRLSYHKDDLIEIQSILAELRKQFRNLKWYAELNKRAFGKILKKLDKKVGTNQQMSTMKTRILPLQFANDSLITKDLSLLKTIWEQVTFRINSYERVMRSTSPNANANDNTEFFKIICVFIEEDDSKGLIRELTNLYSELSLIPTRIMISVLNKAALSKSLACIDAILKVIPSLNDSEDINRRNFFHHHIIAIGKLIRKQEILSRKKKSQPSKYTNSEGEIVTDLRTLHTTLSAPAESDSITEEEKSSACTLSYILEELPIHLRPCLFQHDNYKRTPLHYSCQYGLSEVTKLIIKLMKEWNIWNEIPIDDVSAFGDAESLTPLHLCVLGAHPKTTEVLLQSLDPNVKLKSSSLLHLATEWNNYPLLHVLLSSKRFDINYQDNELHETPLYLACRLNFFEAAVCLLYNGADLEIREKLFGWTAIFVAAAEGFTDIVKLLIANNANFDIEDEGGWTPMEHAVLRGHLHIADMVQIRDELVTHPHSQLNSGSEEKEPLNEISAGELNERNENGNGGNKGSLGKLAGPIKSYGHRFLDNNESLILITLGSNDTRNKSPSISLSSEALAKVIGLETDCALSLVISCNDSIDKSSVILDLPLDDNVDAVDFKVPFKVDYSHTLYFDIVPTYGTRSLETHNRIDCQKNNNNYVMARGVSMLNKSYSSVGVNRSILNGSVTVPIIANHTLEILGTLKFEYIIITPFEHPQLPLERTETYWKSLVSTRVIGHRGLGKNNPNKSLQIGENTVESFIMAASLGASYVEFDVQLTKDNVPVVYHDFLVAETGVDIPMHELTLEQFLDLNNADKEHIQRGAGHSPHHVNGADTALQKYRGRSVDDSDVSTLRRAWDLHDNDPNGKSNNAHWSDNRMRLTKTFKKNNFKGNARGHSIASSFVTLKELFKKIPANVGFNIECKFPMLDEAEEEELGQIMMEMNHWVDTVLKVVFDNANGRDIIFSSFHPDICIMLSLKQPVIPILFLTEGGSEQMADLRASSLQNGIRFAKKWNLLGIVSAAAPILKAPRLVQVVKSNGLVCVTYGVDNNDPENASIQIEAGVDAVIVDSVLAIRRGLTKKNEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61PhosphorylationPTKMRDSSNSAQNYL
CCCCCCCCCHHHHHH		38.8128889911
70PhosphorylationSAQNYLDSPKIQKLL
HHHHHHCCHHHHHHH		26.0427214570
121PhosphorylationQFNEIKSTLVVDANK
CCCCCCCEEEEECCH		20.6928889911
141PhosphorylationQTLLTKDTREMNMLL
HHHHCCCHHHHHHHH		30.0430377154
151PhosphorylationMNMLLKGTSQASRLS
HHHHHHCCCHHHHHH		18.9719823750
152PhosphorylationNMLLKGTSQASRLSY
HHHHHCCCHHHHHHC		32.2019823750
155PhosphorylationLKGTSQASRLSYHKD
HHCCCHHHHHHCCHH		26.5619823750
158PhosphorylationTSQASRLSYHKDDLI
CCHHHHHHCCHHHHH		24.8719823750
159PhosphorylationSQASRLSYHKDDLIE
CHHHHHHCCHHHHHH		19.9219823750
213UbiquitinationNQQMSTMKTRILPLQ
CHHHCCCHHCCHHHH		34.4423749301
254PhosphorylationSYERVMRSTSPNANA
HHHHHHHCCCCCCCC		18.3622369663
255PhosphorylationYERVMRSTSPNANAN
HHHHHHCCCCCCCCC		37.5322369663
256PhosphorylationERVMRSTSPNANAND
HHHHHCCCCCCCCCC		19.8722369663
265PhosphorylationNANANDNTEFFKIIC
CCCCCCCCCEEEEEE		36.7128889911
633PhosphorylationQIRDELVTHPHSQLN
EHHHHHHHCCCHHCC		42.1726447709
637PhosphorylationELVTHPHSQLNSGSE
HHHHCCCHHCCCCCC		40.5926447709
641PhosphorylationHPHSQLNSGSEEKEP
CCCHHCCCCCCCCCC		52.9026447709
643PhosphorylationHSQLNSGSEEKEPLN
CHHCCCCCCCCCCCC		42.2626447709
653PhosphorylationKEPLNEISAGELNER
CCCCCCCCHHHCCCC		24.8428889911
725PhosphorylationAKVIGLETDCALSLV
HHHHCCCCCCCHHEE		41.2327017623
738PhosphorylationLVISCNDSIDKSSVI
EEEECCCCCCCCCEE		20.7827017623
767PhosphorylationKVPFKVDYSHTLYFD
ECCEEECCCEEEEEE		12.8230377154
772PhosphorylationVDYSHTLYFDIVPTY
ECCCEEEEEEEECCC		10.6030377154
781PhosphorylationDIVPTYGTRSLETHN
EEECCCCCCCCCHHC		13.4830377154
794UbiquitinationHNRIDCQKNNNNYVM
HCCEECCCCCCCEEE		68.8923749301
965PhosphorylationIQRGAGHSPHHVNGA
HHCCCCCCCCCCCCH		25.6317563356
983PhosphorylationLQKYRGRSVDDSDVS
HHHHCCCCCCHHHHH		32.4923749301
1105PhosphorylationGRDIIFSSFHPDICI
CCEEEEECCCCCEEH		19.4727017623
1115PhosphorylationPDICIMLSLKQPVIP
CCEEHHHCCCCCEEE		19.0127017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GDE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GDE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GDE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
THG1_YEASTTHG1physical
10688190
NET1_YEASTNET1physical
16554755
SSZ1_YEASTSSZ1physical
19536198
HSP72_YEASTSSA2physical
19536198
HSP71_YEASTSSA1physical
19536198
YNE0_YEASTYNL040Wgenetic
20093466
SIW14_YEASTSIW14genetic
20093466
ADE_YEASTAAH1genetic
21623372
APT2_YEASTAPT2genetic
21623372
GIT1_YEASTGIT1genetic
21623372
PGLR_YEASTPGU1genetic
21623372
RV167_YEASTRVS167genetic
27708008
SIW14_YEASTSIW14genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GDE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-254; SER-256;THR-265 AND SER-653, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-965, AND MASSSPECTROMETRY.

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