PUR92_YEAST - dbPTM
PUR92_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUR92_YEAST
UniProt AC P38009
Protein Name Bifunctional purine biosynthesis protein ADE17
Gene Name ADE17
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 592
Subcellular Localization
Protein Description
Protein Sequence MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MANYTKTAILS
----CCCCCCEEEEE		10.4823749301
11PhosphorylationYTKTAILSVYDKTGL
CCCEEEEEECCCCCH		16.7119795423
13PhosphorylationKTAILSVYDKTGLLD
CEEEEEECCCCCHHH		14.3523749301
15AcetylationAILSVYDKTGLLDLA
EEEEECCCCCHHHHH		27.1424489116
28AcetylationLARGLIEKNVRILAS
HHHHHHHHCCEEEEC		54.4722865919
35PhosphorylationKNVRILASGGTARMI
HCCEEEECCHHHHHH		34.0222369663
38PhosphorylationRILASGGTARMIRDA
EEEECCHHHHHHHCC		18.0222369663
67UbiquitinationEMLGGRVKTLHPAVH
HHHCCCCCCCCHHHH		43.9722817900
68PhosphorylationMLGGRVKTLHPAVHG
HHCCCCCCCCHHHHC		27.6928889911
84PhosphorylationILARDIDSDEKDLKE
EEEECCCCCCHHHHH		48.2628889911
872-HydroxyisobutyrylationRDIDSDEKDLKEQHI
ECCCCCCHHHHHHHH		73.65-
87AcetylationRDIDSDEKDLKEQHI
ECCCCCCHHHHHHHH		73.6524489116
90AcetylationDSDEKDLKEQHIEKV
CCCCHHHHHHHHHHC		66.5124489116
902-HydroxyisobutyrylationDSDEKDLKEQHIEKV
CCCCHHHHHHHHHHC		66.51-
194UbiquitinationAISDFFRKQYSEGQA
HHHHHHHHHCCCCCE		48.7222817900
214UbiquitinationYGANPHQKPAQAYVS
ECCCCCCCCCCEECC		39.0122817900
229UbiquitinationQQDSLPFKVLCGSPG
CCCCCCCEEECCCCC		32.1517644757
251UbiquitinationLNSWPLVKELSASLN
HHCCHHHHHHHHHCC		61.7017644757
266UbiquitinationLPAAASFKHVSPAGA
CCCHHCCCCCCCCCC		40.3717644757
284UbiquitinationIPLSDVEKQVYFVAD
CCHHHHHCEEEEEEE		44.9317644757
355AcetylationEALAILSKKKGGKYC
HHHHHHCCCCCCCEE		55.8724489116
355UbiquitinationEALAILSKKKGGKYC
HHHHHHCCCCCCCEE		55.8717644757
356UbiquitinationALAILSKKKGGKYCI
HHHHHCCCCCCCEEE		53.9617644757
357AcetylationLAILSKKKGGKYCIL
HHHHCCCCCCCEEEE		76.3124489116
360AcetylationLSKKKGGKYCILQID
HCCCCCCCEEEEEEC		45.6924489116
3882-HydroxyisobutyrylationYGVTLEQKRNDAIIN
ECEECHHHHCCCEEC		43.74-
388UbiquitinationYGVTLEQKRNDAIIN
ECEECHHHHCCCEEC		43.7422817900
400AcetylationIINQSTFKEIVSQNK
EECHHHHHHHHHCCC		46.7724489116
400UbiquitinationIINQSTFKEIVSQNK
EECHHHHHHHHHCCC		46.7717644757
434PhosphorylationTQSNSVCYARNGMVV
CCCCCEEEEECCEEE		13.3628889911
460AcetylationCTRLAGDKADNWWFR
EEECCCCCCCCCCHH		57.6422865919
460UbiquitinationCTRLAGDKADNWWFR
EEECCCCCCCCCCHH		57.6422817900
476AcetylationHPRVLEIKWAKGVKR
CCCEEEEEECCCCCC		31.5524489116
4822-HydroxyisobutyrylationIKWAKGVKRPEKSNA
EEECCCCCCCCCCCC		71.54-
482UbiquitinationIKWAKGVKRPEKSNA
EEECCCCCCCCCCCC		71.5422817900
486UbiquitinationKGVKRPEKSNAIDLF
CCCCCCCCCCCEEEE		52.2524961812
517AcetylationSKFEEIPKPFTPEER
HHHCCCCCCCCHHHH		59.4324489116
5252-HydroxyisobutyrylationPFTPEERKEWLSKLT
CCCHHHHHHHHHHHH		57.43-
553UbiquitinationDNVYRAVKSGVKYIA
HHHHHHHHCCCCEEE		40.2722817900
5532-HydroxyisobutyrylationDNVYRAVKSGVKYIA
HHHHHHHHCCCCEEE		40.27-
557AcetylationRAVKSGVKYIAAPSG
HHHHCCCCEEECCCC		34.1724489116
557UbiquitinationRAVKSGVKYIAAPSG
HHHHCCCCEEECCCC		34.1723749301
563PhosphorylationVKYIAAPSGSVMDKV
CCEEECCCCCHHCHH		38.6928152593
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUR92_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUR92_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUR92_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PMU1_YEASTPMU1genetic
15744050
PUR1_YEASTADE4genetic
15744050
SOL1_YEASTSOL1physical
18467557
GIS2_YEASTGIS2physical
18467557
SNC2_YEASTSNC2physical
18467557
SYC_YEASTYNL247Wphysical
18467557
CAF20_YEASTCAF20physical
18467557
HCH1_YEASTHCH1physical
18467557
PUR92_YEASTADE17physical
18467557
ATG17_YEASTATG17genetic
19269370
IPYR2_YEASTPPA2genetic
19269370
SSN3_YEASTSSN3genetic
19269370
PUR91_YEASTADE16genetic
18408719
PUR1_YEASTADE4genetic
20421943
PUR91_YEASTADE16genetic
20421943
PUR91_YEASTADE16genetic
21623372
HPRT_YEASTHPT1genetic
21623372
FCY2_YEASTFCY2genetic
21623372
PUR7_YEASTADE1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
THDH_YEASTILV1genetic
21623372
FUMH_YEASTFUM1genetic
21623372
FOLE_YEASTMET7genetic
21623372
ADE_YEASTAAH1genetic
21623372
ADK_YEASTADO1genetic
21757731
PNPP_YEASTPHO13genetic
21757731
NOP56_YEASTNOP56genetic
27708008
HIR1_YEASTHIR1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
MAK21_YEASTMAK21genetic
27708008
RRP1_YEASTRRP1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
GPI11_YEASTGPI11genetic
27708008
CDC11_YEASTCDC11genetic
27708008
LST8_YEASTLST8genetic
27708008
RPC6_YEASTRPC34genetic
27708008
SMC5_YEASTSMC5genetic
27708008
DYR_YEASTDFR1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
PUR7_YEASTADE1genetic
27708008
STE50_YEASTSTE50genetic
27708008
CRD1_YEASTCRD1genetic
27708008
HPRT_YEASTHPT1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
FLX1_YEASTFLX1genetic
27708008
VPS24_YEASTVPS24genetic
27708008
MIC60_YEASTMIC60genetic
27708008
PUR91_YEASTADE16genetic
27708008
SIN3_YEASTSIN3genetic
27708008
LIPA_YEASTLIP5genetic
27708008
NIP80_YEASTNIP100genetic
27708008
FUMH_YEASTFUM1genetic
27708008
TKT1_YEASTTKL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUR92_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-434, AND MASSSPECTROMETRY.

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