| UniProt ID | T2EA_YEAST | |
|---|---|---|
| UniProt AC | P36100 | |
| Protein Name | Transcription initiation factor IIE subunit alpha | |
| Gene Name | TFA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 482 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).. | |
| Protein Sequence | MDRPIDDIVKNLLKFVVRGFYGGSFVLVLDAILFHSVLAEDDLKQLLSINKTELGPLIARLRSDRLISIHKQREYPPNSKSVERVYYYVKYPHAIDAIKWKVHQVVQRLKDDLDKNSEPNGYMCPICLTKYTQLEAVQLLNFDRTEFLCSLCDEPLVEDDSGKKNKEKQDKLNRLMDQIQPIIDSLKKIDDSRIEENTFEIALARLIPPQNQSHAAYTYNPKKGSTMFRPGDSAPLPNLMGTALGNDSSRRAGANSQATLHINITTASDEVAQRELQERQAEEKRKQNAVPEWHKQSTIGKTALGRLDNEEEFDPVVTASAMDSINPDNEPAQETSYQNNRTLTEQEMEERENEKTLNDYYAALAKKQAKLNKEEEEEEEEEEDEEEEEEEEMEDVMDDNDETARENALEDEFEDVTDTAGTAKTESNTSNDVKQESINDKTEDAVNATATASGPSANAKPNDGDDDDDDDDDEMDIEFEDV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 86 | Phosphorylation | SKSVERVYYYVKYPH CCCEEEEEEEEECHH | 8.69 | 27017623 | |
| 87 | Phosphorylation | KSVERVYYYVKYPHA CCEEEEEEEEECHHH | 10.02 | 27017623 | |
| 90 | Acetylation | ERVYYYVKYPHAIDA EEEEEEEECHHHHHH | 36.62 | 24489116 | |
| 91 | Phosphorylation | RVYYYVKYPHAIDAI EEEEEEECHHHHHHH | 7.10 | 27017623 | |
| 145 | Phosphorylation | QLLNFDRTEFLCSLC HHHCCCCCHHHHHHC | 32.69 | 27017623 | |
| 150 | Phosphorylation | DRTEFLCSLCDEPLV CCCHHHHHHCCCCCC | 33.89 | 27017623 | |
| 161 | Phosphorylation | EPLVEDDSGKKNKEK CCCCCCCCCCCCHHH | 65.91 | 27017623 | |
| 225 | Phosphorylation | TYNPKKGSTMFRPGD EECCCCCCCCCCCCC | 26.11 | 27017623 | |
| 226 | Phosphorylation | YNPKKGSTMFRPGDS ECCCCCCCCCCCCCC | 29.06 | 27017623 | |
| 233 | Phosphorylation | TMFRPGDSAPLPNLM CCCCCCCCCCCCCCC | 37.39 | 27017623 | |
| 242 | Phosphorylation | PLPNLMGTALGNDSS CCCCCCCHHCCCCHH | 12.54 | 27017623 | |
| 366 | Acetylation | DYYAALAKKQAKLNK HHHHHHHHHHHHCCH | 46.39 | 24489116 | |
| 417 | Phosphorylation | EDEFEDVTDTAGTAK HHHHHHCCCCCCCCC | 39.70 | 22369663 | |
| 419 | Phosphorylation | EFEDVTDTAGTAKTE HHHHCCCCCCCCCCC | 20.02 | 22369663 | |
| 422 | Phosphorylation | DVTDTAGTAKTESNT HCCCCCCCCCCCCCC | 23.63 | 29688323 | |
| 427 | Phosphorylation | AGTAKTESNTSNDVK CCCCCCCCCCCCCCC | 51.11 | 28889911 | |
| 430 | Phosphorylation | AKTESNTSNDVKQES CCCCCCCCCCCCHHH | 34.97 | 28889911 | |
| 437 | Phosphorylation | SNDVKQESINDKTED CCCCCHHHHCHHHHH | 24.97 | 28889911 | |
| 460 | Ubiquitination | SGPSANAKPNDGDDD CCCCCCCCCCCCCCC | 44.13 | 19722269 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of T2EA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of T2EA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of T2EA_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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