YD17A_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YD17A_YEAST
• UniProt AC: Q03964
• Protein Name: Transposon Ty1-DR2 Gag polyprotein
• Gene Name: TY1A-DR2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 440
• Subcellular Localization: Cytoplasm.
• Protein Description: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity)..
• Protein Sequence: MESQQLSQHSPISHGSACASVTSKEVQTTQDPLDISASKTEECEKVFTQANSQQPTTPPSAAVPENHHHASPQAAQVPLPQNGPYPQQRMMTPQQANISGWPVYGHPSLMPYPPYQMSPMYAPPGAQSQFTQYPQYVGTHLNTPSPESGNSFPDSSSAKSNMTSTNQHVRPPPILTSPNDFLNWVKIYIKFLQNSNLGDIIPTATRKAVRQMTDDELTFLCHTFQLFALSQFLPTWVKDILSVDYTDIMKILSKSINKMQSDTQEVNDITTLANLHYNGSTPADAFEAEVTNILDRLKNNGIPINNKVACQFIMRGLSGEYKFLRYARHRYIHMTVADLFSDIHSMYEEQQESKRNKSTYRRSPSDEKKDSRTYTNTTKPKSITRNSQKPNNSQSRTARAHNVSTSNNFPGPDNDLIRGSTTEPIQLKNKHDLHLRPGTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESQQLSQHS -----CCCCCHHCCC	23.17	22369663
7	Phosphorylation	-MESQQLSQHSPISH -CCCCCHHCCCCCCC	22.85	22369663
10	Phosphorylation	SQQLSQHSPISHGSA CCCHHCCCCCCCHHH	19.11	22369663
13	Phosphorylation	LSQHSPISHGSACAS HHCCCCCCCHHHCCC	25.77	22369663
16	Phosphorylation	HSPISHGSACASVTS CCCCCCHHHCCCCCC	18.10	22369663
20	Phosphorylation	SHGSACASVTSKEVQ CCHHHCCCCCCCCCC	26.30	22369663
22	Phosphorylation	GSACASVTSKEVQTT HHHCCCCCCCCCCCC	31.42	22369663
23	Phosphorylation	SACASVTSKEVQTTQ HHCCCCCCCCCCCCC	25.35	22369663
24	Ubiquitination	ACASVTSKEVQTTQD HCCCCCCCCCCCCCC	53.17	24961812
36	Phosphorylation	TQDPLDISASKTEEC CCCCCCCCCCCHHHH	26.59	29688323
38	Phosphorylation	DPLDISASKTEECEK CCCCCCCCCHHHHHH	33.06	21440633
40	Phosphorylation	LDISASKTEECEKVF CCCCCCCHHHHHHHH	34.22	21440633
71	Phosphorylation	PENHHHASPQAAQVP CCCCCCCCCCHHCCC	17.12	17330950
139	Phosphorylation	QYPQYVGTHLNTPSP CCCCCCCCCCCCCCC	17.10	18407956
143	Phosphorylation	YVGTHLNTPSPESGN CCCCCCCCCCCCCCC	31.35	28889911
145	Phosphorylation	GTHLNTPSPESGNSF CCCCCCCCCCCCCCC	38.98	28889911
160	Phosphorylation	PDSSSAKSNMTSTNQ CCCHHCCCCCCCCCC	31.39	21440633
163	Phosphorylation	SSAKSNMTSTNQHVR HHCCCCCCCCCCCCC	36.33	19795423
164	Phosphorylation	SAKSNMTSTNQHVRP HCCCCCCCCCCCCCC	18.00	19795423
165	Phosphorylation	AKSNMTSTNQHVRPP CCCCCCCCCCCCCCC	29.72	19795423
250	Ubiquitination	VDYTDIMKILSKSIN CCHHHHHHHHHHHHH	40.61	24961812
318	Phosphorylation	QFIMRGLSGEYKFLR HHHHCCCCCHHHHHH	32.19	20377248
322	Acetylation	RGLSGEYKFLRYARH CCCCCHHHHHHHHHH	33.35	25381059
322	Ubiquitination	RGLSGEYKFLRYARH CCCCCHHHHHHHHHH	33.35	23749301
358	Phosphorylation	QESKRNKSTYRRSPS HHHHHCCCCCCCCCC	33.93	19823750
359	Phosphorylation	ESKRNKSTYRRSPSD HHHHCCCCCCCCCCC	23.74	19823750
360	Phosphorylation	SKRNKSTYRRSPSDE HHHCCCCCCCCCCCC	15.89	19823750
363	Phosphorylation	NKSTYRRSPSDEKKD CCCCCCCCCCCCCCC	21.54	17287358
365	Phosphorylation	STYRRSPSDEKKDSR CCCCCCCCCCCCCCC	60.70	17287358
371	Phosphorylation	PSDEKKDSRTYTNTT CCCCCCCCCCCCCCC	35.09	28889911
377	Phosphorylation	DSRTYTNTTKPKSIT CCCCCCCCCCCCCCC	28.53	28889911
382	Phosphorylation	TNTTKPKSITRNSQK CCCCCCCCCCCCCCC	37.41	21440633
404	Phosphorylation	TARAHNVSTSNNFPG HHHHCCCCCCCCCCC	31.28	28132839
406	Phosphorylation	RAHNVSTSNNFPGPD HHCCCCCCCCCCCCC	23.44	28889911
420	Phosphorylation	DNDLIRGSTTEPIQL CCCCCCCCCCCCEEC	23.47	22369663
421	Phosphorylation	NDLIRGSTTEPIQLK CCCCCCCCCCCEECC	37.69	24909858
422	Phosphorylation	DLIRGSTTEPIQLKN CCCCCCCCCCEECCC	41.27	22369663
439	Phosphorylation	DLHLRPGTY------ CCCCCCCCC------	28.83	17287358
440	Phosphorylation	LHLRPGTY------- CCCCCCCC-------	23.60	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YD17A_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YD17A_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YD17A_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of YD17A_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.